Silicosis is a systemic disease caused by inhalation of free crystalline silicon dioxide or silica. Phagocytosisof crystalline silica in the lung causes inflammatory cascade with subsequent fibrosis, resulting in systemic inflammatory response. Although more and more studies were undertaken to dissect the pathological mechanisms underlying the processof silicosis, the primary cause of this often devastaing dissease remains elusive. Diagnosis of silicosis could easily be missed, since which needs carefully documented records of occupational exposure and radiological features, with exclusion of other competing diagnoses. As yet, no curative treatment exists, but comprehensive management strategies help to improve quality of life and slow deterioration. Thus, further efforts are needed to find early molecular marker of diagnosis, new target to control the fibrosis induced by silica.

Clinical evidence indicated that activation of alveolar macrophage induced by silica produces a rapid and sustained inflammation characterized by generation of monocyte chemotactic protein 1 (MCP-1) and MCP-1 induced protein 1 (MCPIP1, ZC3H12A). Our previous studies also suggested that MCPIP1 played a critical role in fibroblast proliferation and migration. However, the detailed cellular and molecular mechanisms underlying inflammation and the subsequent fibrosis in response to silica remain unknown. Therefore, we hypothesized that MCPIP1 will be the potential target of curative treatment for silicosis involving in regulation of inflammation and fibrosis. The proposed studies will be initiated in human sample followed by study in intact animals as well as primary cell cultures. Studies using classic pharmacological methods will be combined with molecular biological techniques, as well as  immunological methods, all of which are currently well established in our laboratory. This research is both novel and innovative in that the efficacy of regulation of MCPIP1 expression can be of value to prevent or halt progression of silicosis in people. Our study will decipher the link between MCPIP1 and inflammation with subsequent fibrosis induced by silica,  providing a novel insight into the potential of MCPIP1 in terms of opening up novel therapeutic avenues for silicosis.

Post-Doc position is available!

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• ∎  Editorial Board Member of Scientific Reports (an online, open access journal from the publishers of Nature)

• ∎  Member of American Thoracic Society (ATS)-379520

• ∎  Member of Society of Toxicology (SOT)

• ∎  Member of American Physiological Society (APS)-00167524

• ∎ Pre-doctoral Fellowship from the American HeartAssociation, Midwest Affiliate entitled “Mechanisms of microvascular inflammation induced by alveolar hypoxia” from July 2008 to June 2010

• ∎  First place of oral presentation in Cardiovascular Biology research topics of KUMC Student Research Forum 2009

2024

1.  Wang L, Tang Y, Tang J, Liu X, Zi S, Li S, Chen H, Liu A, Huang W, Xie J, Liu, L, Chao J#, Qiu H#.  Endothelial cell-derived  extracellular  vesicles  expressing surface VCAM1 promote sepsis-related acute lung  injury  by  targeting  and  reprogramming  monocytes.  J  Extracell  Vesicles. 2024, 13:e12423. (SCI, IF:16, Q1) PubMedPDF T-49

2. Zhou X*, Zhang C*, Yang S*, Yang L, Luo W, Zhang W, Zhang X, Chao J#. Macrophage-derived MMP12 promotes pulmonary fibrosis through sustained damage to endothelial cells in silicosis. J Hazard Mater. 2024, 461:132733. (SCI, IF:13.6, Q1) PubMedPDFWOS:001099138000001 T-48

3. Wu Z, Liu X, Huang W, Chen J, Li S, Chao J, Xie J, Liu L, Yang Y, Wu X#, Qiu H#. CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis. Int Immunopharmacol. 2024, 132：111924. (SCI, IF:5.6, Q1) PubMed PDF

4. He W, Chao J, Gu  A, Wang D#. Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics. Sci Total Environ.2024, 922:171220. (SCI, IF:9.8, Q1)PubMedPDF

2023

Zhang X, Shi X, Xie F, Liu Y, Wei X, Cai Y, Chao J#. Dissecting pulmonary fibroblasts heterogeneity in lung development, health and diseases. Heliyon. 2023, 9:e19428. (SCI, IF:4, Q2) PubMedPDF WOS:001069550200001

2. Yang S*, Sun Y*, Long M*, Zhou X*, Yuan M, Yang L， Luo W, Cheng Y, Zhang X, Jiang W#, Chao J#. Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis. Part Fibre Toxicol. 2023, 20(1):29. (SCI, IF:10, Q1) PubMedPDF WOS:001029441200001

3. Chen M*, Wang J*, Yuan M*, Long M, Sun Y, Wang S, Luo W, Zhou Y, Zhang W, Jiang W#, Chao J#. AT2 cell–derived IgA trapped by the extracellular matrix in silica-induced pulmonary fibrosis. Int Immunopharmacol. 2023, 122：110545. (SCI, IF:5.6, Q1) PubMedPDF WOS:001030607200001

4.Wang J, Zhang X, Long M, Yuan M, Yin J, Luo W, Wang S, Cai Y, Jiang W#, Chao J#. Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis. Commun Bio. 2023, 6:136. (SCI, IF:5.9, Q1) PubMedPDF WOS:000925802900005

5.Li B*, Xi W*, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J#, Han B#, Yao H#. FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. Nat Commun. 2023, 14(1):489. (SCI, IF:16.6, Q1) PubMedPDF WOS:000955780200014

6. Chen Z*, Huang J*, Zhang J*, Xu Z, Li Q, Ouyang J, Yan Y, Sun S, Ye H, Wang F, Zhu J, Wang Z, Chao J#, Pu Y#, Gu Z#. A storm in a teacup - A biomimetic lung microphysiological system in conjunction with a deep-learning algorithm to monitor lung pathological and inflammatory reactions. Biosens Bioelectron. 2023, 219:114772. (SCI, IF:12.6, Q1) PubMedPDF WOS:000885971400004

7. Hua X, Feng X, Liang G, Chao J, Wang D#. Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpse engulfment in Caenorhabditis elegans. J Hazard Mater. 2023, 454:131495 (SCI, IF:13.6, Q1) PubMedPDF WOS:000991104000001

8. Hua X, Feng X, Liang G, Chao J, Wang D#. Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans. Environ Sci Technol.2023, 57(12):4940-4950. (SCI, IF:11.4, Q1) PubMedPDF WOS:000953458700001

2022

1. Liu Y*, Zhang X*, Wang J*, Yang F*, Luo W, Huang J, Chen M, Wang S, Li C#, Zhang W#, Chao J#. ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10. Resp Res. 2022, 23：204.(SCI, IF:5.8, Q1) PubMedPDF WOS:000840090800001

2. Shi X*, Wang J*, Zhang X*, Yang S, Luo W, Wang S, Huang J, Chen M, Cheng Y#, Chao J#. GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis. Cell Biosci. 2022, 12:123. (SCI, IF:7.5, Q1) PubMedPDF WOS:00083677850000

3. Wang S*, Luo W*, Huang J, Chen M, Ding J, Cheng Y, Zhang W, Fang S, Wang J#, Chao J#.  The combined effects of circRNA methylation promote pulmonary fibrosis. Am J Resp Cell Mol Biol. 2022,66(5):510-523.(SCI, IF:6.4, Q1)PubMed PDF (Highlighted Paper,Editorial) WOS:000790563500010

4. Yin J*, Wang J*, Zhang X*, Liao Y*, Luo W, Ding J, Huang J, Chen M, Wang W#, Fang S#, Chao J#.A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation. Cell Biosci. 2022,12:21. (SCI, IF:7.5, Q1) PubMedPDF WOS:000769551500002

5. Ghafoor H, Chu H, Huang J, Chen M, Wang S, Wang J#, Chao J#. ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop. Toxicol Appl Pharmacol. 2022, 435,115856. (SCI, IF:3.8, Q1) PubMedPDF WOS:000789925000001

6. Han B, Xi W, Hong Y, Gu L, Chao Y, Li L, Liu C, Yang L, Chao J#, Yao H#.  Mutual regulation of noncoding RNAs and RNA modifications in psychopathology: Potential therapeutic targets for psychiatric disorders? Pharmacol Ther. 2022,108254.(SCI, IF:13.5, Q1) PubMedPDF WOS:000843902000002

7. Li S#, Chen Z, Zhang W, Wang T, Wang X, Wang C, Chao J#, Liu L#. Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression. Carcinogenesis. 2022, 43(11):1092-1102. (SCI, IF:4.7, Q2) PubMedPDF WOS:000851216300001

8. Hua X, Feng X, Liang G, Chao J, Wang D. Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans. Sci Total Environ. 2022, 861:160591. (SCI, IF:9.8, Q1) PubMedPDF

9. Yu X, Bai Y, Han B, Ju M, Tang T, Shen L, Li M, Yang L, Zhang Z, Hu G, Chao J, Zhang Y#, Yao H#. Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours. J Extracell Vesicles. 2022 Jan;11(1):e12185. (SCI, IF:16, Q1) PubMedPDF WOS:000742199800001

10.Wang L, Wen L, Zheng S, Tao F, Chao J, Wang F, Li C. Integrating peroxidase-mimicking NH2-MIL-101(Fe) with molecular imprinting for high-performance ratiometric fluorescence sensing of domoic acid. Sensor Actuat B-Chem. 2022, 361:131688.(SCI, IF:8.4, Q1) PubMed PDF WOS:000782121600003

11. Wang L, Wen L, Zhao L, Chao J, Tao F, Wang F, Li C. Development of fluorescence sensor and test paper based on molecularly imprinted carbon quantum dots for spiked detection of domoic acid in shellfish and lake water. Anal Chim Acta. 2022, 1197,338515. (SCI, IF:6.2, Q1) PubMedPDF WOS:000750845200011

12. Liu X, Wang F, Meng Y, Zhao L, Shi W, Wang X, He Z, Chao J, Li C.Electrochemical/visual microfluidic detection with a covalent organic framework supported platinum nanozyme-based device for early diagnosis of pheochromocytoma. Biosens Bioelectron. 2022 Mar 23;207:114208. (SCI, IF:12.6, Q1) PubMedPDFWOS:000788141300001

13. Zhou X, Zhang W, ChaoJ#. Macrophage differential genes and their functions in silicosis based on single cell RNA se-quencing and spatial transcriptome sequencing. Journal of Environmental and Occupational Medicine.2022, 39(12): 1350-1358. PDF

14. Yang S, Shi X, Cheng Y, Chao J#. Specific expression of FABP5 in type II alveolar epithelial cells in silicosis pulmonary fibrosis based on single-cell transcriptome sequencing. Journal of Environmental and Occupational Medicine. 2022, 39(10):1089-1094. PDF

15.Shi X, Yang S, Cheng Y, Chao J#. PPP2R3A promotes silicosis by regulating the expression of p53. Journal of China Pharmaceutical University. 2022. 53(4):491 - 498

2021

1.Dai X, Cheng Y, Wang C, Huang J, Chao J#. Role of Circular RNAs in Visceral Organ Fibrosis. Food Chem Toxicol. 2021.150:112074.(SCI, IF:5.572, Q1) PubMedPDF

2.Jiang R#, Han L, Gao Q, Chao J#. ZC3H4 Mediates Silica-induced EndoMT via ER Stress and Autophagy. Environ Toxicol Pharmacol. 2021, 84:103605. (SCI, IF:5.785, Q2) PubMedPDF

3.Cheng Y, Luo W, Shen L, Chao J#. Exploration on the "Curriculum -based Ideological and Political Education" of "Physiology" in Medical Education under the Epidemic of Novel Coronavirus Pneumonia.The Science Education Article Collects. 2021,517(1),54-58PDF

4.Luo W, Wang S, Li Y, Wang J, Chao J#. Differential on N6-methyladenosine modification of circRNA in early inflammation of silicosis. Chin J Ind Hyg Occup Dis. 2021, 39(12), 899-902 PDF

2020

1.Huang J, Huang J, Ning X, Luo W, Chen M, Wang Z, Zhang W, Zhang Z#, Chao J#. CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis. J Mater Chem B. 2020, 8 (8), 1713-1727. (SCI, IF:6.331, Q1) PubMedPDF

2.Huang J, Huang, J, Bao H, Ning X, Yu C, Chen Z, Chao J#, Zhang Z#. CT/MR dual-Modal Imaging tracking of mesenchymal stem cells labeled with Au/GdNC@SiO2 nanotracer in pulmonary fibrosis. ACS Applied Bio Materials. 2020, 3, 2489-2498.  ACSPDF

3.Zhang W, Zhu T, Chen L, Luo W, Chao J#. MCP-1 mediates ischemia/reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR. Am J Physiol Heart Circ Physiol. 2020,318(1):H59-H71. (SCI, IF:4.733, Q1) PubMedPDF
4.Chen L, Luo W, Zhang W, Chu H, Wang J, Dai X, Cheng Y, Zhu T#, Chao J#. circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress. RNA Biology. 2020, 17(2):240-253.(SCI, IF:4.652, Q1) PubMed PDF

2019

1.Chu H, Wang W, Luo W, Zhang W, Cheng Y, Huang J, Wang J, Dai X, Fang S, Chao J#. circHECTD1 mediates pulmonary fibroblast activation via HECTD1. Ther Adv Chronic Dis. 2019, Vol. 10: 1-18.(SCI, IF:4.257,Q1) PubMedPDF

2.Jiang R, Liao Y, Yang F, Cheng Y, Dai X, Chao J#. SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO2. Exp Cell Res.2019, 383(1):111492. (SCI, IF:3.383, Q2) PubMedPDF

3.Cheng Y, Luo W, Li Z, Cao M, Zhu Z, Han C, Dai X, Zhang W, Wang J, Yao H, Chao J#. CircRNA-012091/PPP1R13B-mediated lung fibrotic response in silicosis via ER stress andaautophagy. Am J Resp Cell Mol Biol. 2019, 61(3):380-391. (SCI, IF:5.373, Q1) PubMedPDF

4.Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, Wang J, Chen H, Zhu T, Chao J#. The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial tomesenchymal transition. Toxicol Lett. 2019; 307:26-40. (SCI, IF:3.569, Q2) PubMedPDF

5.Zhang Y, Huang R, Cheng M, Wang L, Chao J, Li J, Zheng P, Xie P, Zhang Z, Yao H. Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. Microbiome. 2019; 7(1):116. (SCI, IF:11.607, Q1) PubMedPDF

6.Cheng Y, Chao J, Chen C, Lv L, Han Y, Liu B#. The PKCβ-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy. J Pharm  Pharmacol. 2019, 71(3):338-347. (SCI, IF:2.571, Q2) PubMedPDF

7.Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H. Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis. Toxicol Lett. 2019; 301:53-63. (SCI, IF:3.569, Q2) PubMedPDF

8.Zhao L, Du L, Zhang Y, Chao J, Duan M, Yao H, Shen C, Zhang Y. Role of PUMA in the methamphetamine-induced migration of microglia. Metab Brain Dis. 2019, 34(1):61-69.(SCI, IF:2.726, Q2) PubMedPDF

9.Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H, Zhang H, Gu L, Li J, Hu G, Xie C, Zhang Z, Yao H. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination.  Mol Psychiatry. 2018 Nov 9. doi: 10.1038/s41380-018-0285-0. (SCI, IF:12.384, Q1) PubMedPDF

2018

1.Fang S, Guo H, Cheng Y, Zhou Z, Zhang W, Han B, Luo W, Wang J, Xie W#, Chao J#. circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Cell Death Dis. 2018;9(3):396. (SCI, IF:5.959, Q1)PubMedPDF

2.Yang X*, Wang J*, Zhou Z*, Jiang R, Huang J, Chen L, Cao Z, Chu H, Han B, Cheng Y, Chao J#. Silica-induced initiation of circZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation. FASEB J. 2018, 32(6):3264-3277. (SCI, IF:5.391, Q1) PubMedPDF

3.Zhou Z, Jiang R, Yang X, Guo H, Fang S, Zhang Y, Cheng Y, Wang J, Yao H, Chao J#. circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. Theranostics. 2018; 8:575-592. (SCI, IF:8.063, Q1) PubMedPDF

4.Chao J#, Lv Y, Chen J, Wang J, Yao H. SiO2-induced release of sVEGFRs from pulmonary macrophages. Respir Physiol Neurobiol. 2018; 247:1-8. (SCI, IF:1.582, Q3) PubMedPDF

5.Xie X*, Zhu T*#, Chen L, Ding S, Chu H, Wang J, Yao H, Chao J#. MCPIP1-induced autophagy mediates ischemia/referfusion injury in endothlial cells via HMGB1 and CaSR. Sci Rep. 2018; 8(1):1735. (SCI, IF:4.011, Q1) PubMedPDF

6.Zhang Y, Shu G, Bai Y, Chao J, Chen X, Yao H. Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers. Metab Brain Dis. 2018, 33(5):1585-1597. (SCI, IF:2.411, Q2) PubMedPDF

7.Han B, Zhang Y, Zhang Y, Bai Y, Chen X, Huang R, Wu F, Leng S, Chao J, Zhang JH, Hu G, Yao H. Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. Autophagy. 2018;14:1164-1184. (SCI, IF:11.059, Q1) PubMedPDF

8.Han B, Chao J, Yao H. Circular RNA andits mechanisms in disease: From the bench to the clinic.Pharmacol Ther. 2018, 187:31-44. (SCI, IF:9.396, Q1) PubMedPDF

9.Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, Wu F, Chao J, Liu P, Hu G, Zhang JH, Yao H.Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity. J Neurosci.2018; 38:32-50. (SCI, IF:6.074, Q1) PubMedPDF

10.Yang L, Han B, Zhang Y, Bai Y, Chao J, Hu G, Yao H. Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition. Autophagy. 14(3):404-418. (SCI, IF:11.059, Q1) PubMedPDF    65.005

2017

1.Cao Z*, Xiao Q*, Dai X*, Zhou Z, Jiang R, Cheng Y, Yang X, Guo H, Wang J, Xi Z, Yao H, Chao J#. circHIPK2-mediated σ-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica. Cell Death Dis. 2017; 8:3212. (SCI, IF:5.638, Q1) PubMedPDF

2.Liu H, Cheng Y, Yang J, Wang W, Fang S, Zhang W, Han B, Zhou Z, Yao H, Chao J#, Liao H#: BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis. Cell Death Dis. 2017; 8:e2657. (SCI, IF:5.638, Q1) PubMedPDF

3.Chao J, Zhang Y, Du L, Zhou R, Wu X, Shen K, Yao H. Molecular mechanisms underlying the involvement of the sigma-1 receptor in methamphetamine-mediated microglial polarization.Sci Rep. 2017; 7(1):11540. (SCI, IF:4.122, Q1)PubMedPDF

4.Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling Epilepsy-Induced Hippocampal Endoplasmic Reticulum Stress and Oxidative Damage. Front Cell Neurosci. 2017; 11:377. (SCI, IF:4.3, Q2) PubMedPDF

5.Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior. Front Behav Neurosci. 2017; 11:203. (SCI, IF:3.138, Q2) PubMedPDF

6.Zhang X, Wu F, Jiao Y, Tang T, Yang L, Lu C, Zhang Y, Zhang Y, Bai Y, Chao J, Teng G, Yao H. An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2017 26:1981-1987(SCI, IF:1.598, Q4) PubMed PDF

7.Huang R, Zhang Y, Han B, Bai Y, Zhou R, Gan G, Chao J, Hu G, Yao H. Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy. 2017,13(10):1722-1741. (SCI, IF:11.1, Q1) PubMedPDF

8.Casillan AJ, Chao J, Wood JG, Gonzalez NC. Acclimatization of the systemic microcirculation to alveolar hypoxia is mediated by iNOS-dependent increased nitric oxide availability. J Appl Physiol. 2017,123(4):974-982. (SCI, IF:3.256, Q2) PubMed PDF

9.Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X, Yao H. Involvement of PUMA in pericyte migration induced by methamphetamine. Exp Cell Res. 2017;356:28-39. (SCI, IF:3.309, Q2) PubMedPDF

10.Zhu X, Dong J, Xia Z, Zhang A, Chao J, Yao H. Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress. Neurochem Int. 2017;110:25-37. (SCI, IF:3.603, Q2) PubMed PDF

11.Cheng Y, Chao J, Dai D, Dai Y, Zhu D, Liu B. AQP4-knockout aggravation of isoprenaline-induced myocardial injury is mediated by p66Shc and endoplasmic reticulum stress. Clin Exp Pharmacol Physiol. 2017; 44:1106-1115. (SCI, IF:2.092, Q3) PubMed PDF 47.794

2016

1.Liu H, Fang S, Wang W, Cheng Y, Zhang Y, Liao H, Yao H#, Chao J#. Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy. Part Fibre Toxicol. 2016; 13: 55. (SCI, IF:8.577, Q1) PubMedPDF

2.Chao J*#, Wang X*, Zhang Y*, Zhu T, Zhang W, Zhou Z, Yang J, Han B, Cheng Y, Tu X, Yao H#. Role of MCPIP1 in the endothelial-mesenchymaltransition induced by silica. Cell Physiol Biochem. 2016; 40:309-325. (SCI, IF:5.104, Q1) PubMedPDF

3.Zhang W, Zhang M, Wang Z, Cheng Y, Liu H, Zhou Z, Han B, Chen B, Yao H#, Chao J#. Neogambogic Acid Prevents Silica-induced Fibrosis via Inhibition of High-mobility group box1 and MCP-1-induced protein 1. Toxicol Appl Pharmacol. 2016; 309:129-140.  (SCI, IF:3.791, Q1) PubMedPDF

4.Zhu T, Yao Q, Wang W, Yao H, Chao J#. iNOS induced vascular endothelial cell migration andapoptosis via autophagy in ischemia/reperfusion injury. Cell Physiol Biochem. 2016; 38: 1575-1588. (SCI, IF:5.104, Q1) PubMedPDF

5.Wang X, Zhang Y, Zhang W, Liu H, Zhou Z, Dai X, Cheng Y, Fang S, Zhang Y, Yao H, Chao J#: MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation after in vitro exposure to silica. Toxicol Sci. 151(1):126-38.   (SCI, IF:4.081, Q1) PubMedPDF

6.Liu H, Dai X, Cheng Y, Fang S,Zhang Y, Wang X, Zhang W, Liao H, Yao H, Chao J#: MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts. Am J Physiol-Lung C. 2016; 310(2):L121-L132. (SCI, IF:4.281, Q1) PubMedPDF

7.Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, Zhu X, Huang W, Chao J, Zhou R, Hu G, Yao H. Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse. Sci Rep. 2015; 6:35642.  (SCI, IF:4.259, Q1) PubMedPDF

8.Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, Yao H.Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis andautophagy: Implications for methamphetamine-mediated neurotoxicity. Autophagy. 2016,12(9):1538-59. (SCI, IF:8.593, Q1) PubMedPDF

9.Zhu X, Shen K, Bai Y, Zhang A, Xia Z, Chao J, Yao H.NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy. Free Radic Biol Med. 2016; 94:230-242. (SCI, IF:5.606, Q1) PubMedPDF

10.Zhu X, Dong J, Shen K, Bai Y, Chao J, Yao H. Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis.Brain Res Bull. 2016. 121:138-47. (SCI, IF:3.033, Q3) PubMed PDF

11.Zhang Y, Huang R, Zhang Y, Yi H, Bai Y, Chao J, Yao H. IL-17 induces MIP-1α expression in primary mouse astrocytes via TRPC channel. Inflammopharmacology. 2016, 24(1):33-42. (SCI, IF:2.59, Q3) PubMed 55.019

2015

1.Wang W, Liu H, Dai X, Fang S, Wang X, Zhang Y, Yao H, Zhang X#, Chao J#:  p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis.Sci Rep. 2015; 5:16900.  (SCI, IF:5.228, Q1)   PubMedPDF

2.Zhu T, Yao Q, Hu X, Chen C, Yao H, Chao J#: The role of MCPIP1 in ischemia/reperfusion injury-induced HUVEC migration and apoptosis. Cell Physiol Biochem. 2015;37:577-591.(SCI, IF:4.652, Q1)   PubMedPDF

3.Liu X, Fang S, Liu H, Wang X, Dai X, Yin Q, Yun T, Wang W, Zhang Y, Liao H, Zhang W, Yao H, Chao J#: Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. Toxicol Appl Pharmacol. 2015; 288:152-160. (SCI, IF:3.847, Q1) Global Medical DiscoveryPubMedPDF

4.Chao J, Dai X, Pena T, Doyle DA, Guenther TM, Carlson MA: MCPIP1 regulates fibroblast migration in 3-D collagen matrices downstream of MAP kinases and NF-kappa B. J Invest Dermatol. 2015; 135:2944-54.  (SCI, IF:6.915, Q1) PubMedPDF

5.Bai Y*, Zhu X*, Chao J*, Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, Yao H: Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGFR expression: Implications for stroke. PLoS One. 2015;10:e0124362. (SCI, IF:3.057, Q1) PubMedPDF

6.Zhang Y, Lv X, Bai Y, Zhu X, Wu X, Chao J, Duan M, Buch S, Chen L, Yao H: Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulationof its own expression. J Neuroinflammation. 2015;12:29. (SCI, IF:4.667, Q1) PubMedPDF

7.Zhang Y, Zhu T, Zhang X, Chao J, Hu G, Yao H: Role of high-mobility group box 1 inmethamphetamine-induced activation and migration of astrocytes. J Neuroinflammation.2015;12:156. (SCI, IF:4.667, Q2) PubMedPDF

8.Zhu X, Dong J, Shen K, Bai Y, Zhang Y, Lv X, Chao J, Yao H: NMDA receptor NR2b subunits contribute to ptz-kindling-induced hippocampal astrocytosis and oxidative stress. Brain Res Bull. 2015;114:70-78.(SCI, IF:2.572, Q3)  PubMedPDF 35.605

Before 2015

1.Yi H, Bai Y, Zhu X, Lin L, Zhao L, Wu X, Buch S, Wang L, Chao J#, Yao H#: IL-17a induces MIP-1alpha expression in primary astrocytes via Src/MAPK/PI3K/NF-kB pathways:Implications for multiple sclerosis. J Neuroimmune Pharmacol.2014;9:629-641. (SCI, IF:4.11, Q2)  PubMedPDF

2.Chao J*, Yang L*, Yao H, Buch S: Platelet-derived growth factor-bb restores HIV Tat -mediated impairment of neurogenesis: Role of GSK-3beta/beta-catenin. J Neuroimmune Pharmacol.2014;9:259-268.  (SCI, IF:4.11, Q2)  PubMedPDF

3.Chao J, Pena T, Heimann DG, Hansen C, Doyle DA, Yanala UR, Guenther TM, Carlson MA: Expression of green fluorescent protein in human foreskin fibroblasts for use in 2D and 3D culture models. Wound Repair Regen.2014;22:134-140. (SCI, IF:2.768, Q1) Cover story MDLinxGlobal Medical DiscoveryPubMedPDF

4.Chao J, Yang L, Buch S, Gao L: Angiotensin II increased neuronal stem cell proliferation: Role of AT2R. PLoS One.2013;8:e63488. (SCI, IF:3.534) PubMedPDF

5.Yang L*, Chao J*, Kook YH, Gao Y, Yao H, Buch SJ: Involvement of mir-9/MCPIP1 axis in PDGF-bb-mediated neurogenesis in neuronal progenitor cells. Cell Death Dis.2013;4:e960. (SCI, IF:5.177) PubMedPDF

6.Carlson MA, Smith LM, Cordes CM, Chao J, Eudy JD: Attachment-regulated signaling networks in the fibroblast-populated 3D collagen matrix. Sci Rep.2013;3:1880. (SCI, IF:5.078)  PubMedPDF

7.Chao J, Gao J, Parbhu KJ, Gao L: Angiotensin type 2 receptors in the intermediolateral cell column of the spinal cord: Negative regulation of sympathetic nerve activity and blood pressure. Int J Cardiol. 2013;168:4046-4055. (SCI, IF:6.175)  PubMedPDF

8.Chao J, Viets Z, Donham P, Wood JG, Gonzalez NC: Dexamethasone blocks the systemic inflammation of alveolar hypoxia at several sites in the inflammatory cascade. Am J Physiol Heart Circ Physiol.2012;303:H168-177. (SCI, IF:3.629) PubMedPDF

9.Gao J, Chao J, Parbhu KJ, Yu L, Xiao L, Gao F, Gao L: Ontogeny of angiotensin type 2 and type1 receptor expression in mice. J Renin Angiotensin Aldosterone Syst.2012;13:341-352. (SCI, IF:2.286)  PubMedPDF

10.Chao J, Blanco G, Wood JG, Gonzalez NC: Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia. Am J Physiol Heart Circ Physiol.2011;301:H2264-2270. (SCI, IF:3.708) PubMedPDF

11.Chao J, Wood JG, Gonzalez NC: Alveolar macrophages initiate the systemic microvascular inflammatory response to alveolar hypoxia. Respir Physiol Neurobiol.2011;178:439-448. (SCI, IF:2.242) PubMedPDF

12.Gao J, Zhang H, Le KD, Chao J, Gao L: Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens.2011;24:724-730. (SCI, IF:3.181) PubMedPDF

13.Chao J, Donham P, van Rooijen N, Wood JG, Gonzalez NC: Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia. Am J Respir Cell Mol Biol.2011;45:53-61. (SCI, IF:5.125) PubMedPDF

14.Chao J, Wood JG, Gonzalez NC: Alveolar hypoxia, alveolar macrophages, and systemic inflammation. Respir Res.2009;10:54. (SCI, IF:3.36) PubMedPDF

15.Chao J, Wood JG, Blanco VG, Gonzalez NC: The systemic inflammation of alveolar hypoxia is initiated by alveolar macrophage-borne mediator(s). Am J Respir Cell Mol Biol.2009;41:573-582. (SCI, IF:5.125) PubMedPDF

16.Meng X, Chao J, Xiang Y: Identification from diversemammalian poxviruses of host-range regulatory genes functioning equivalently tovaccinia virus C7l. Virology.2008;372:372-383. (SCI, IF:3.351) PubMedPDF 51.971