陈佳林,男,本科至博士毕业于浙江大学,2018年10月入职东南大学医学院,副教授,博士生导师。2024年8月兼任东南大学附属中大医院眼科,科研副主任。主要研究方向为利用组织工程原理实现富含胶原组织(肌腱、软骨、角膜等)的修复与再生,着重关注在此过程中物理微环境(力学、拓扑结构、基底硬度)对干细胞行为和分化命运的调控作用。已发表SCI论文60篇(总影响因子>400,被引4000余次,H指数33),其中一作和通讯论文36篇(10分以上10篇),发表在 Science Advances, Advanced Materials, Advanced Science, Biomaterials, Bioactive Materials 等杂志。
教育经历:
2009.09 - 2014.06 浙江大学基础医学院,硕博连读,干细胞和再生医学专业
导师:欧阳宏伟 教授
2014.01 - 2014.05 澳大利亚西澳大学,访问学者
导师:郑铭豪 教授
2005.09 - 2009.06 浙江大学竺可桢学院,本科,生物科学专业
工作经历:
2024.08 - 至今 东南大学附属中大医院眼科,科研副主任
2018.10 - 至今 东南大学医学院,副教授
2014.09 - 2018.08 瑞典于默奥大学,博士后
导师:Patrik Danielson 教授
学术任职:
中国生物医学工程学会组织工程与再生医学分会委员
国际华人骨研学会(ICMRS)终身会员
中华医学会骨科学分会青年委员
中国医师协会骨科医师分会青年委员会骨科基础学组委员
中国骨科再生医学会(CORMed)成员
Journal of Biological Engineering期刊副主编
Discover Applied Sciences 期刊副主编
Biomimetics 期刊编委
Military Medical Research 期刊青年编委
Interdisciplinary Medicine 期刊青年编委(2023-2024)
Biomedicines 期刊首席客座编辑(2023-2024)
Stem Cells International 期刊客座编辑(2017-2018)
Applied Bionics and Biomechanics 期刊首席客座编辑(2017)
兼任数十本国际知名SCI期刊的审稿人,期刊包括 Advanced Materials, Advanced Functional Materials, Advanced Science, Biomaterials, Bioactive Materials, Small 等
科研项目:
江苏省自然科学基金--面上项目,2024.07-2027.06,主持
中央高校基本科研业务费-院系联合基金项目,2024.04-2025.03,主持
东南大学大型仪器设备分析测试基金项目,2023.06-2024.05,主持
国家重点研发计划,2024.01-2026.12,参与
横向项目,2022.04-2025.03,主持
山东省重点研发计划,2022.01-2024.12,参与
南京市留学人员科技创新项目择优资助A类,2020.09-2021.08,主持
东南大学“至善青年学者”支持计划资助,2020.01-2022.12,主持
国家自然科学基金--青年基金项目,2020.01-2022.12,主持
江苏省自然科学基金--青年基金项目,2019.07-2022.06,主持
(省优势)新进教师人才引进启动费,2019.01-2020.12,主持
东南大学基础科研扶持项目,2019.04-2019.12,主持
东南大学中央高校建设一流大学(学科)和特色发展引导专项资金经费,2019
参编书籍:
《再生医学:基础与临床》 2013,人民卫生出版社
《疫苗工程学》 2020,东南大学出版社
代表性论文:
1. Chen JL#*, Sheng RW#, MoQY#, Backman LJ#, Lu ZY, Long QZ, Chen ZX, Cao ZC, Zhang YN, Liu CQ, Zheng HT, Qi Y, Cao MM, Rui YF*, ZhangW*. Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling. Bioact Mater. 2025, 44, 319-338. (IF=18.0)
2. Sun YZ#, Sheng RW#, Cao ZC, Liu CQ, Li JX, Zhang P, Du Y, Mo QY, Yao QQ*, Chen JL*, Zhang W*. Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural andfunctional regeneration of myotendinous junction. Sci Adv. 2024, 10(17), eadm7164. (IF=11.7)
3. Sheng RW#, Liu J#, Zhang W#,Luo YF, Chen ZX, Chi JY, Mo QY, Wang MY, Sun YZ, Liu CQ, Zhang YN, Zhu Y, KuangBA, Yan CG, Liu HY, Backman LJ, Chen JL*.Material Stiffness in Cooperation with Macrophage Paracrine Signals Determinesthe Tenogenic Differentiation of Mesenchymal Stem Cells. Adv Sci. 2023, 10(17), e2206814 (IF=14.3)
4. Chen JL*, Mo QY, Sheng RW, Long QZ, Chen ZX, Liu CQ, Zhang AN,Luo YF, Liu J, Zhang W*. Stiffness-dependent dynamic effect of inflammation onkeratocyte phenotype and differentiation. Biomed Mater. 2023, 18(4), 045001 (IF=3.9)
5. Zhang YN#, Sheng RW#, Chen JL#, Wang HM#,Zhu Y, Cao ZC, Zhao XY, Wang ZM, Liu CQ, Chen ZX, Zhang P, Kuang BA, Zheng HT,Shen CL, Yao QQ, Zhang W*. Silk Fibroin and Sericin Differentially Potentiatethe Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis. Adv Mater. 2023, 35(20), e2210517 (IF=27.4)
6. Chen JL#*, Mo QY#, Long QZ, Sheng RW, Chen ZX, LuoYF, Liu CQ, Backman LJ, Zhang YN, Zhang W*. Hydroxycamptothecin and substratum stiffness synergistically regulate fibrosis of human corneal fibroblasts. ACS Biomater Sci Eng. 2023, 9(2), 959-967 (IF=5.4)
7. Chen ZX#, Zhang W#, Wang MY,Backman LJ, Chen JL*. Effects of zinc, magnesium and iron ions on bonetissue engineering. ACS Biomater Sci Eng, 2022, 8(6), 2321-2335(IF=5.4)
8. Zhang W*, Zhang YN, Li XL, Cao ZC, Mo QY, Sheng RW,Ling C, Chi JY, Yao QQ*, Chen JL*, Wang HM*. Multifunctional polyphenol-based silk hydrogel alleviates oxidative stress and enhances endogenous regeneration of osteochondral defects. Materials Today Bio. 2022,14, 100251 (IF=8.7)
9. Zhang AN#, Zhang W#, Backman LJ, Chen JL*. Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes. Stem Cells Int. 2022, 2022, 5403995 (IF=3.8)
10. Chen JL*, Mo QY, Sheng RW, Zhu AJ, Ling C, Luo YF, Zhang AN, Chen ZX, Yao QQ, CaiZY*, Zhang W*. The application of human periodontal ligament stem cells andbiomimetic silk scaffold for in situ tendon regeneration. Stem Cell Res Ther. 2021,12(1), 596 (IF=7.1)
11. Sheng RW, Jiang YJ, Backman LJ, Zhang W*, Chen JL*.The application of mechanical stimulations in tendon tissue engineering. Stem Cells Int. 2020, 2020, 8824783 (IF=3.8)
12. Chen J*, Backman LJ, Zhang W, Ling C, Danielson P*.Regulation of keratocyte phenotype and cell behavior by substrate stiffness. ACS Biomater Sci Eng. 2020, 6(9), 5162-5171 (IF=5.4)
13. Zhang W*, Ling C, Zhang AN, Liu HY, Jiang YJ, Li XL,Sheng RW, Yao QQ*, Chen JL*. An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration. Bioact Mater. 2020, 5(4), 832-843 (IF=18.0)
14. Zhang W*, Ling C, Liu HY, Zhang AN, Mao L, Wang J,Chao J, Backman L, Yao QQ*, Chen JL*. Tannic Acid-Mediated Dual Peptide-Functionalized Scaffolds to Direct Stem Cell Behavior and Osteochondral Regeneration. Chem Eng J. 2020, 396(125232), 125232 (IF=13.3)
15. Chen J#, Zhang W#, Backman LJ, Kelk P, andDanielson P*. Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes. Br J Ophthalmol. 2018, 102(4),562-569 (IF=3.7)
16. Chen J#, Zhang W#, Kelk P, Backman LJ, and DanielsonP*. Substance P and Patterned Silk Biomaterial Stimulate Periodontal Ligament Stem Cells to Form Corneal Stroma in a Bioengineered 3D Model. Stem Cell Res Ther. 2017, 8(1), 260 (IF=7.1)
17. Chen J#, Zhang E#, Zhang W, Liu Z, Lu P, Zhu T,Yin Z, Backman, LJ, Liu H, Chen X*, Ouyang HW*. Fos Promotes Early StageTeno-Lineage Differentiation of Tendon Stem/Progenitor Cells in Tendon. Stem Cells Transl Med. 2017, 6(11), 2009-2019(IF=5.4)
18. Chen JL,Lan J, Liu DL, Backman LJ, Zhang W, Zhou QJ*,Danielson P*.Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/Progenitor Cellsand Accelerates Epithelial Wound Healing in the Cornea. Stem Cells Transl Med. 2017, 6(5), 1356-1365(IF=5.4)
19. Chen JL, Zhang W, Liu ZY, Zhu T, Shen WL, Ran JS, Tang QM, Gong XN, Backman LJ, Chen X, Chen XW, Wen FQ*, Ouyang HW*. Characterization and comparison of post-natal rat Achilles tendon-derived stem cells at different development stages. Sci Rep. 2016, 6, 22946 (IF=3.8)
20. Chen JL#, Yin Z#, Shen WL, Chen X, Heng BC, Zou XH, Ouyang HW*. Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials. 2010, 31(36), 9438-9451 (IF=12.8, 被引284次)
注:上述标注均为2023年度影响因子:2023 JournalCitation Reports (Clarivate Analytics 2024)。