陈佳林，男，1987年生。本科至博士毕业于浙江大学，2018年10月入职东南大学医学院，副教授，博士生导师。主要研究方向为利用组织工程原理实现富含胶原组织（肌腱、软骨、角膜等）的修复与再生，着重关注在此过程中物理微环境（力学、拓扑结构、基底硬度）对干细胞行为和分化命运的调控作用。已发表SCI论文50余篇（总影响因子>450，被引3600余次，H指数29），其中一作和通讯论文30余篇（10分以上9篇），发表在 Science Advances, Advanced Materials, Advanced Science, Biomaterials, Bioactive Materials 等杂志。
教育经历：
2009.09 - 2014.06 浙江大学基础医学院，硕博连读，干细胞和再生医学专业
导师：欧阳宏伟 教授
2014.01 - 2014.05 澳大利亚西澳大学，访问学者
导师：郑铭豪 教授
2005.09 - 2009.06 浙江大学竺可桢学院，本科，生物科学专业
工作经历：
2018.10 - 至今 东南大学医学院，副教授
2014.09 - 2018.08 瑞典于默奥大学，博士后
导师：Patrik Danielson 教授
学术任职：
中国生物医学工程学会组织工程与再生医学分会委员
国际华人骨研学会（ICMRS）终身会员
中华医学会骨科学分会青年委员
中国医师协会骨科医师分会青年委员会骨科基础学组委员
中国骨科再生医学会（CORMed）成员
Discover Applied Sciences 期刊副主编
Biomimetics 期刊编委
Military Medical Research 期刊青年编委
Interdisciplinary Medicine 期刊青年编委
Biomedicines 期刊首席客座编辑（2023）
Stem Cells International 期刊客座编辑（2017-2018）
Applied Bionics and Biomechanics 期刊首席客座编辑（2017）
兼任近30本国际知名SCI期刊的审稿人，期刊包括 Advanced Materials, Advanced Functional Materials,Biomaterials,Bioactive Materials, Small,Military Medical Research等
目前作为 Biomedicines (IF=4.7) 期刊的首席客座编辑，负责Special Issue "Repair and Regeneration of Tendon, Cartilage and Cornea"。欢迎投稿！
网址：https://www.mdpi.com/journal/biomedicines/special_issues/15GO69A83E
科研项目：
国家重点研发计划，2024.01-2026.12，参与
横向项目，2022.04-2025.03，负责人
山东省重点研发计划，2022.01-2024.12，参与
南京市留学人员科技创新项目择优资助A类，2020.09-2021.08，负责人
东南大学“至善青年学者”支持计划资助，2020.01-2022.12，负责人
国家自然科学基金--青年基金项目，2020.01-2022.12，负责人
江苏省自然科学基金--青年基金项目，2019.07-2022.06，负责人
（省优势）新进教师人才引进启动费，2019.01-2020.12，负责人
东南大学基础科研扶持项目，2019.04-2019.12，负责人
东南大学中央高校建设一流大学（学科）和特色发展引导专项资金经费，2019
参编书籍：
《再生医学：基础与临床》 2013，人民卫生出版社
《疫苗工程学》 2020，东南大学出版社
发表论文：
1. Sun YZ#, Sheng RW#, Cao ZC, Liu CQ, Li JX, Zhang P, Du Y, MoQY, Yao QQ*, Chen JL*, Zhang W*. Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural and functional regeneration of myotendinous junction. Sci Adv. 2024, accepted (IF=13.6)
2. Tong SQ#, Sun YZ#, Kuang BA, Wang MY, Chen ZX,Zhang W*, Chen JL*. A Comprehensive Review of Muscle-tendon Junction: Structure, Function, Injury and Repair. Biomedicines. 2024, 12(2), 423(IF=4.7)
3. ZhuY#, Chen JL#, LiuHY#, Zhang W*. Photocrosslinked Hydrogels for Cartilage and osteochondral Repair. ACS Biomater Sci Eng, 2023, 9(12), 6567-6585 (IF=5.8)
4. Sheng RW#, Liu J#, Zhang W#, Luo YF, Chen ZX, Chi JY, Mo QY, Wang MY, Sun YZ, Liu CQ, Zhang YN, Zhu Y, Kuang BA, Yan CG, Liu HY, Backman LJ, Chen JL*. Material Stiffness in Cooperation with Macrophage Paracrine Signals Determines the Tenogenic Differentiation of Mesenchymal Stem Cells. Advanced Science, 2023, 2206814 (IF=15.1)
5. Chen JL*, Mo QY, Sheng RW, LongQZ, Chen ZX, Liu CQ, Zhang AN, Luo YF, Liu J, Zhang W*. Stiffness-dependent dynamic effect of inflammation on keratocyte phenotype and differentiation. Biomedical Materials, 2023, 18, 045001 (IF=4.0)
6. Zhang YN#, Sheng RW#, Chen JL#, Wang HM#, Zhu Y, Cao ZC, Zhao XY, Wang ZM, Liu CQ, Chen ZX, Zhang P, Kuang BA, Zheng HT, Shen CL, Yao QQ, Zhang W*. Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis. Adv Mater, 2023: e2210517 (IF=29.4)
7. Chen JL#*, Mo QY#, Long QZ, Sheng RW, Chen ZX, Luo YF, Liu CQ, Backman LJ, Zhang YN, Zhang W*. Hydroxycamptothecin and substratum stiffness synergistically regulate fibrosis of human corneal fibroblasts. ACS Biomater Sci Eng, 2023, 9(2), 959-967 (IF=5.8)
8. Zhang P#, Chen JL#, Sun YZ, Cao ZC, Zhang YN, Mo QY, Yao QQ*, Zhang W*. 3D Multifunctional Bi-layer Scaffold to Regulate Stem Cell Behaviors and Promote Osteochondral Regeneration. Journal of Materials Chemistry B. 2023, 11(6), 1240-1261 (IF=7.0)
9. Cao ZC#, Wang HM#, Chen JL#, Zhang YN, Mo QY, Zhang P, Wang MY, Liu HY, Bao XY, Sun YZ, Zhang W*, Yao QQ*. Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration. Bioact Mater. 2023;20:221-242. (IF=18.9)
10. Chi JY#, Wang MY#, Chen JL#, Hu LZ, Chen ZX, Backman LJ, Zhang W*. Topographic Orientation of Scaffolds for Tissue Regeneration: Recent Advances in Biomaterial Design and Applications. Biomimetics. 2022, 7, 131 (IF=4.5)
11. Sheng RW#, Chen JL#, Wang HM#, Luo YF, Liu J, Chen ZX, Mo QY, Chi JY, Ling C, Tan X, Yao QQ, Zhang W*. Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of both Cartilage and Subchondral Bone. Adv Healthc Mater.2022:e2200602. (IF=10.0)
12. Chen ZX#, Zhang W#, Wang MY, BackmanLJ, Chen JL*. Effects of zinc, magnesium and iron ions on bone tissueengineering. ACS Biomater Sci Eng,2022, 8(6), 2321-2335. (IF=5.8)
13. Mo QY#, Zhang W#, Zhu AJ, Backman LJ, Chen JL*. Regulation of osteogenic differentiation by thepro-inflammatory cytokines IL-1β and TNF-α: Current conclusions and controversies. Human Cell, 2022, 35(4), 957-971. (IF=4.3)
14. Zhang W*, Zhang YN, Li XL, Cao ZC, Mo QY, Sheng RW, Ling C, Chi JY, Yao QQ*, Chen JL*, Wang HM*. Multifunctional polyphenol-based silk hydrogel alleviates oxidative stress and enhances endogenous regeneration of osteochondral defects. Materials Today Bio, 2022,14:100251. (IF=8.2)
15. Zhang AN#, Zhang W#, Backman LJ,Chen JL*. Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes. Stem Cells International 2022, 2022: 5403995 (IF=4.3)
16. Chen JL*, Mo QY, Sheng RW, Zhu AJ, Ling C, Luo YF, Zhang AN, Chen ZX, Yao QQ, Cai ZY*, Zhang W*. The application of human periodontal ligamentstem cells and biomimetic silk scaffold for in situ tendon regeneration. Stem Cell Res Ther 2021;12:596 (IF=7.5)
17. Liu H#, Chen J#, Qiao S#,Zhang W*. Carbon-Based Nanomaterials for Bone and Cartilage Regeneration: A Review. Acs Biomater Sci Eng 2021, 7:4718-4735. (IF=5.8)
18. Zhang W*, Zhang YN, Zhang AN, Ling C, Sheng RW, Li XL,Yao QQ*, Chen JL*. Enzymatically Crosslinked Silk-Nanosilicate Reinforced Hydrogel with Dual-Lineage Bioactivity for Osteochondral Tissue Engineering. Mat Sci Eng C-Mater. 2021,127:112255. (IF=7.9)
19. Zhang W*, Ling C, Li XL, Sheng RW, Liu HY, Zhang AN, Jiang YJ, Chen JL*, Yao QQ*. Cell-Free Biomimetic Scaffold with Cartilage Extracellular Matrix-Like Architectures for In Situ Inductive Regeneration of Osteochondral Defects. ACS Biomater Sci Eng 2020,6, 6917-6925. (IF=5.8)
20. Sheng RW, Jiang YJ, Backman LJ, Zhang W*, Chen JL*.The application of mechanical stimulations in tendon tissue engineering. StemCells International 2020, 2020: 8824783. (IF=4.3)
21. Chen J*, Backman LJ, Zhang W, Ling C, Danielson P*. Regulationof keratocyte phenotype and cell behavior by substrate stiffness. ACS Biomaterials Science & Engineering 2020. 6(9): 5162-5171. (IF=5.8)
22. Zhang W*, Ling C, Zhang AN, Liu HY, Jiang YJ, Li XL,Sheng RW, Yao QQ*, Chen JL*. An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration. Bioactive Materials. 2020, 5:832-843. (IF=18.9)
23. Zhang W*, Ling C, Liu HY, Zhang AN, Mao L, Wang J, Chao J, Backman L, Yao QQ*, Chen JL*. Tannic Acid-Mediated Dual Peptide-Functionalized Scaffolds to Direct Stem Cell Behavior and Osteochondral Regeneration. Chem Eng J. 2020, 396:125232. (IF=15.1)
24. Chen J#, Zhang W#, Backman LJ, Kelk P, and Danielson P*. Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes. Br J Ophthalmol 2018; 102; 562-569 (IF=4.1)
25. Chen J#, Zhang W#, Kelk P, Backman LJ, and Danielson P*. Substance P and Patterned Silk Biomaterial Stimulate Periodontal Ligament Stem Cells to Form Corneal Stroma in a Bioengineered 3D Model. Stem Cell Res Ther 2017;8:260 (IF=7.5)
26. Chen J#, Zhang E#,Zhang W, Liu Z, Lu P, Zhu T, Yin Z, Backman, LJ, Liu H, Chen X*, Ouyang HW*.Fos Promotes Early Stage Teno-Lineage Differentiation of Tendon Stem/ProgenitorCells in Tendon. Stem Cells Transl Med.2017. 6(11): 2009-2019. (IF=6.0)
27. Chen JL,Lan J, Liu DL, Backman LJ, Zhang W, Zhou QJ*, Danielson P*. Ascorbic Acid Promotesthe Stemness of Corneal Epithelial Stem/Progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea. Stem Cells Transl Med. 2017; 6(5): 1356-1365.(IF=6.0)
28. Chen J, Chen P, Backman LJ, Zhou Q*, Danielson P*. Ciliary Neurotrophic Factor Promotes the Migration of Corneal EpithelialStem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt. Sci Rep 2016;6:25870. (IF=4.6)
29. Chen JL, Zhang W, Liu ZY, Zhu T, Shen WL, Ran JS, Tang QM, Gong XN, Backman LJ, Chen X, Chen XW, Wen FQ*, Ouyang HW*. Characterization and comparison of post-natal rat Achilles tendon-derived stem cells at different development stages. Sci Rep 2016;6:22946. (IF=4.6)
30. Chen JL, Zhang W, Liu ZY, Heng BC, Ouyang HW*, Dai XS*. Physical regulation of stem cells differentiation into teno-lineage: current strategies and future direction. Cell Tissue Res 2015. 360(2):195-207.(IF=3.6)
31. Shen WL#, Chen JL#, Zhu T, Yin Z, Chen X, Chen LK, Fang Z, Heng BC, JiJF, Chen WS*, Ouyang HW*, Osteoarthritis prevention through meniscalregeneration induced by intra-articular injection of meniscus stem cells. Stem Cells Dev, 2013. 22(14): p. 2071-82. (封面文章, IF=4.0)
32. Zhang W#, Chen JL#, Tao JD, Hu CC, Chen LK, Zhao HS, Xu GW, HengBC, Ouyang HW*. The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantationof a bi-layer collagen-silk scaffold. Biomaterials, 2013. 34(25): p. 6046-57. (IF=14.0, 被引89次)
33. Shen W#, Chen J#, Yin Z, Chen X, Liu H, Heng BC, Chen W*, OuyangHW*. Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair. Cell Transplant 2012;21(5):943-958. (IF=3.3, 被引133次)
34. ChenJL#, Yin Z#, Shen WL, Chen X, Heng BC, Zou XH, Ouyang HW*. Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials 2010. 31(36):9438-9451. (IF=14.0, 被引271次)
35. LiJ, Zhou X, Chen J, Eliasson P,Kingham PJ, Backman LJ*. Secretomefrom myoblasts statically loaded at low intensity promotes tenocyte proliferationvia the IGF-1 receptor pathway. FASEB J,2023.37(10): p. e23203. (IF=4.8)
36. Wang YF#, Ling C#, Chen JL, Liu HY, Mo QY, Zhang W*, YaoQQ*. 3D-printed composite scaffold with gradient structure and programmed biomolecule delivery to guide stem cell behavior for osteochondral regeneration. Biomaterials Advances, 2022, 140: 213067.
37. Zhang W*, Chen JL, Qu ML, Backman J, Zhang AN,Liu HY, Zhang XP, Zhou QJ*, Danielson P*. Sustained release of TPCA-1 from silkfibroin hydrogels preserves keratocyte phenotype and promotes cornealregeneration by inhibiting interleukin-1β signaling. Adv Healthc Mater. 2020,9(17): e2000591. (IF=10.0)
38. He SQ, Ruan DF, Chen YW, Ran JS, Chen X, Yin Z, TangCQ, Huang JY, Heng BC, Chen JL, Chen WS*, Shen WL*, Ouyang HW. Characterizationand Comparison of Postnatal Rat Meniscus Stem Cells at Different DevelopmentalStages. StemCells Transl Med. 2019, 8:1318-1329.(IF=6.0)
39. El-Habta R*, ChenJL, Pingel J, Backman LJ. Tendinosis-like changes in denervated ratAchilles tendon. BMC Musculoskelet Disord.2018, 19:426. (IF=2.3)
40. Zhang W, Li Y, Jiang DM, Xie SJ, Zeng MF, Chen JL, Chen LK, Ouyang HW*, Zou XH*.Promotion of Hernia Repair with High-Strength, Flexible, and Bioresorbable SilkFibroin Mesh in a Large Abdominal Hernia Model. ACS Biomaterials Science & Engineering2018 4 (6), 2067-2080.(IF=5.8)
41. Spang C*, Backman LJ, Le RS, Chen J, Danielson P. Glutamate signaling through the NMDA receptorreduces the expression of scleraxis in plantaris tendon derived cells. BMC Musculoskelet Disord.2017. 18(1): 218. (IF=2.3)
42. Zhang W, Chen L, ChenJ, Wang L, Gui X, Ran J, Xu G, Zhao H, Zeng M, Ji J, Qian L, Zhou J, OuyangH*, Zou X*. Silk Fibroin Biomaterial Shows Safe and Effective Wound Healing inAnimal Models and a Randomized Controlled Clinical Trial. Adv Healthc Mater2017.6. (封面文章, IF=10.0)
43. Zhang W, Chen J,Backman LJ, Malm AD, Danielson P*. Surface Topography and Mechanical StrainPromote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic3D Corneal Model. Adv Healthc Mater.2017. 6(5). (封面文章, IF=10.0)
44. Spang C*, ChenJ, Backman LJ. The tenocyte phenotype of human primary tendon cells invitro is reduced by glucocorticoids. BMCMusculoskelet Disord. 2016;17:467.(IF=2.3)
45. Yin Z#, Hu JJ#, Yang L, ZhengZF, An CR, Wu BB, Zhang C, Shen WL, Liu HH, Chen JL, Heng BC, Guo GJ, Chen X*, Ouyang HW*. Single-cell analysis reveals anestin+ tendon stem/progenitor cell population with strong tenogenicpotentiality. Science Advances, 2016. 2(11):e1600874-e1600874. (IF=13.6)
46. Yin Z#, Chen X#, Song HX, Hu JJ,Tang QM, Zhu T, Shen WL, Chen JL,Liu H, Heng BC, Ouyang HW*. Electrospun scaffolds for multiple tissuesregeneration in vivo through topography dependent induction of lineage specificdifferentiation. Biomaterials2015;44:173-185. (IF=14.0)
47. Tang QM, ChenJL, Shen WL, Yin Z, Liu HH, Fang Z, Heng BC, Ouyang HW*, Chen X*. Fetal andadult fibroblasts display intrinsic differences in tendon tissue engineeringand regeneration. Sci Rep2014;4:5515. (IF=4.6)
48. Shen WL, ChenJL, Zhu T, Chen LK, Zhang W, Fang Z, Heng BC, Yin Z, Chen X, Ji JF, Chen WS*,Ouyang HW*. Intra-Articular Injection of Human Meniscus Stem/Progenitor CellsPromotes Meniscus Regeneration and Ameliorates Osteoarthritis Through StromalCell-Derived Factor-1/CXCR4-Mediated Homing. Stem Cells Transl Med, 2014.3(3): p. 387-94. (IF=6.0)
49. Chen X#, Yin Z#, Chen JL, Liu HH, Shen WL, Fang Z, ZhuT, Ji JF, Ouyang HW, Zou XH*. Scleraxis-overexpressed human embryonic stemcell-derived mesenchymal stem cells for tendon tissue engineering with knittedsilk-collagen scaffold. Tissue Eng Part A,2014. 20(11-12): p. 1583-92. (IF=4.1)
50. Fang Z, Zhu T, Shen WL, Tang QM, Chen JL, Yin Z, Ji JF, Heng BC, Ouyang HW, Chen X*. Transplantationof fetal instead of adult fibroblasts reduces the probability of ectopicossification during tendon repair. TissueEng Part A, 2014. 20(13-14): p.1815-26. (IF=4.1)
51. Shen W#, Chen X#, Hu Y, Yin Z,Zhu T, Hu J, Chen J, Zheng Z, ZhangW, Ran J, Heng BC, Ji J, Chen W*, Ouyang HW*. Long-term effects of knittedsilk-collagen sponge scaffold on anterior cruciate ligament reconstruction andosteoarthritis prevention. Biomaterials 2014;35(28):8154-8163. (IF=14.0)
52. Zhang W, Chen J,Tao J, Jiang Y, Hu C, Huang L, Ji JF*, Ouyang HW*. The use of type 1 collagenscaffold containing stromal cell-derived factor-1 to create a matrixenvironment conducive to partial-thickness cartilage defects repair. Biomaterials2013;34(3):713-723. (IF=14.0)
53. Chen X#, Yin Z#, Chen JL, Shen WL, Liu HH, Tang QM, FangZ, Lu LR, Ji JF*, Ouyang HW*. Force and scleraxis synergistically promote thecommitment of human ES cells derived MSCs to tenocytes. Sci Rep, 2012. 2: p.977. (IF=4.6)
54. Zou XH, Jinag YZ, ChenJL, Chen X, Ouyang HW*. Tissue engineering for soft tissue regeneration. Science. 2012 April:(Suppl:regenerative medicine in China): 33-34. (Science专刊)
55. Zhang W, Chen J,Zhang S, Ouyang HW*. Inhibitory function of parathyroid hormone-related proteinon chondrocyte hypertrophy: the implication for articular cartilage repair. Arthritis Res Ther2012;14(4):221. (IF=4.9)
56. Yin Z#, Chen X#, Chen JL, Shen WL, Hieu NT, Gao L, OuyangHW*. The regulation of tendon stem cell differentiation by the alignment ofnanofibers. Biomaterials 2010;31(8):2163-2175. (IF=14.0)
57. Shen W, Chen X, Chen J, Yin Z, Heng BC, Chen W*, Ouyang HW*. The effect of incorporation of exogenous stromalcell-derived factor-1 alpha within a knitted silk-collagen sponge scaffold ontendon regeneration. Biomaterials2010;31(28):7239-7249. (IF=14.0)
58. Yin Z#, Chen X#, Chen JL, Ouyang HW*. Stem cells fortendon tissue engineering and regeneration. ExpertOpin Biol Ther2010;10(5):689-700. (IF=4.6)
注：上述标注均为2022年度影响因子：2022 JournalCitation Reports (Clarivate Analytics 2023)。