Research Fields
  • Biomaterials: Hydrogels and Nanofibers

  • Drug delivery systems: Liposomes and Nanoparticles


 

 

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Honor Reward

入选2011年江苏省“青蓝工程”学术带头人

2009年度江苏省人民政府颁发的省科学技术进步奖二等奖,列第1位

入选2007年“华英学者”,获华英文教基金会资助赴哈佛医学院研究基因药物

2006年度江苏省科学技术进步奖二等奖,列第3位

2002年常州市人民政府奖教基金奖助

政府资助:

1.国家自然科学基金,51373034,氨基酸水凝胶生物材料:制备与眼科应用,2014-2017,负责

2.国家自然科学基金,51073036,新型同步互穿网络硅水凝胶材料的研究, 2011-2013,负责

3.国家自然科学基金,50673019,多重共轭电纺方法制备纳米纤维连续长纱的研究,2007-2009,负责

4.国家自然科学基金,50573011,电纺玉米蛋白纳米纤维生物材料的基础研究,2006-2008,负责.

5.江苏省产学研前瞻性联合研究项目,BY2015070-11,中空纤维过滤膜亲水/抗粘附改性研究,2015-2017,负责

6.江苏省产学研项目,BY2010143,系列水凝胶角膜接触镜的研究与产业化开发,江苏省科技厅,2010.7-2012.12,负责

7.江苏省社会发展研究,BS2001034,生物可吸收聚合物/纳米晶骨折内固定材料研究,2001-2003,负责

8.江苏省高技术研究基金,BG2001036,骨组织工程关键技术研究,2001-2003,参加

9.江苏省高技术研究基金,BG2002002,生物吸收高分子/纳米晶体复合材料制备技术与临床应用,2002-2004,负责

10.南京市科学基金,200301046,壳聚糖防粘连材料制备技术与临床,2003-2004,负责

11.国家科学技术部“863”科技专项,2004AA2Z3540,氯硝柳胺新剂型的研究, 2004-2005,参加

12.国家卫生部专项基金, wkj2006-2-024,血吸虫病新型树枝状载体-DNA疫苗的研究, 2006-2008,参加

企业资助:

13.苏州某公司,高端中空纤维过滤膜的亲水性改性研究与产业化开发,2013-2015,负责

14.某外资企业,系列水凝胶角膜接触镜的研制及其产业化,2009-2011,负责

15.某外资企业,功能角膜接触镜材料的研究,2007-2008,负责

16.某外资企业,超含水角膜接触镜材料的研究,2007-2008,负责

17.某外资企业,收缩血管滴眼液的研发,2006-2007,负责

18.某外资企业,水凝胶角膜接触镜材料的研究,2006-2007,负责

19.法国某公司,大规模连续电纺纳米纤维制造技术,2005,负责

20.四川某医疗器械企业,可吸收高分子纳米纤维生物材料,2003-2004,负责

21.常州某公司,二乙烯三胺五乙酸的合成,2001-2002,负责


Academic Achievements

Representive Publications:

1.Yongpeng Hou, Chen Yao*, Longbing Ling, Yawei Du, Ruiyu He,Muhammad Ismail, Ying Zhang, Zhenglin Fu, Xinsong Li*, Novel Dual VESPhospholipid Self-assembled Liposomes with an Extremely High Drug Loading Efficiency,Colloidsand Surfaces B: Biointerfaces, 2017, 156, 2937.

2.Longbing Ling, Yawei Du, Ruiyu He, Muhammad Ismail, YongpengHou, Chen Yao, Xinsong Li*, Self-assembled nanoparticles of dualpaclitaxel-phospholipid prodrug with in vitro and in vivo anticanceractivities, International Journal of Pharmaceutics, 2017,  526(1-2),1122.

3.Yawei Du, Wei Zhang, Ruiyu He, Muhammad Ismail, Longbing Ling,Chen Yao and Xinsong Li* Dual 7-Ethyl-10-hydroxycamptothecin ConjugatedPhospholipid Prodrug Assembled Liposomes with in vitro Anticancer Effects,Bioorganic & Medicinal Chemistry, 2017, 25(12), 32473258.

4.Longbing Ling, Chen Yao, Yawei Du, Muhammad Ismail, Ruiyu He,Yongpeng Hou, Ying Zhang, Xinsong Li*, Assembled liposomes of dualpodophyllotoxin phospholipid: preparation, characterization and in vivoanticancer activity, Nanomedicine,  2017,12(6): 657-672.

5.Ruiyu He, Yawei Du, Longbing Ling, Muhammad Ismail, Yongpeng Hou,Chen Yao and Xinsong Li*, Nanoformulation of dual bexarotene-tailedphospholipid conjugate with high drug loading , European Journal ofPharmaceutical Sciences, 2017, 100: 197204.

6.Chen Xu, Ruiyu He, Binbin Xie, Chen Yao, Jie Luan, and XinsongLi*,Improved protein resistance of silicone hydrogels by grafting shortpeptides for ophthalmological application, International Journal of Polymeric Materials and PolymericBiomaterials,2017, 66(12), 618-625.

7.Chen Xu, Xiaojiu Liu, BinbinXie, Chen Yao, Wenhan Hu, Yi Li,Xinsong Li. Preparation of PES ultrafiltrationmembranes with natural aminoacids based zwitterionic antifouling surfaces.Applied Surface Science,2016, 385,130-138.

8.Chen Xu,Ruiyu He, Binbin Xie,Muhammad Ismail, Chen Yao, JieLuan, and Xinsong Li*,Silicone hydrogels graftedwith natural aminoacids for ophthalmological application, Journal ofBiomaterials Science, Polymer Edition, 2016, online

9.Wei Zhang, Wenjun Zhu, ShuoFang, YeminZhang, Chen Yao, Muhammad Ismail, Xinsong Li*,Improvementofstability and in vitro anticancer activity ofchlorambucil-tetrapeptideconjugate vesicles, Chinese Journal of Chemistry,2016,on line.

10.Shuo Fang, Yuge Niu,Wei Zhang,Yemin Zhang, Liangli Yu,Yingyi Zhang, and Xinsong Li*,Liposome-likenanocapsules of dual drug-tailed betaine for cancer therapy,International Journal of Pharmaceutics, 2015, 493(1-2), 460–465

11.Xu, Chen; Hu, Xin; Wang, Jie;Zhang, Yemin; Liu, Xiaojiu; Xie,Binbin; Yao, Chen; Li, Yi; Li, Xinsong*, Libraryof Antifouling SurfacesDerived From Natural Amino Acids by Click Reaction, ACSApplied Materials &Interfaces, 2015,7(31):17337-45

12.Xiao-jiu Liu, Ye-min Zhang,Xin-song Li*, Tough biopolymer IPNhydrogel fibers by bienzymatic crosslinkingapproach, Chinese Journal of Polymer Science, 2015,33(12): 1741-1749

13.Zhiping Fan, Yemin Zhang andXinsong Li*,In situ injectablepoly(c-glutamic acid) based biohydrogel formed byenzymatic crosslinking , J.Appl. Polym. Sci. 2015, 2015,13230

14.ShuoFang, Yuge Niu, Wenjun Zhu,Yemin Zhang, Liangli Yu and Xinsong Li*, Liposomesassembled from a dualdrug-tailed phospholipid for cancer therapy, Chemistry-an Asian journal, 2015,10(5),1232–1238.

15.Yemin Zhang, Zhiping Fan, ChenXu, Shuo Fang,Xiaojiu Liu, Xinsong Li*,Biopolymer based hydrogelswithinterpenetrating network structure by bienzymaticcrosslinking approach,Europe Polymer Journal, 2015. doi:10.1016/j.eurpolymj.2014.12.038.

16.Zhiping Fan, Yemin Zhang,Jinkai Ji andXinsong Li*,Hybrid polypeptide hydrogels produced via native chemicalligation, RSV Adv., 2015,5, 16470

17.Wenjun Zhu, Shuo Fang, YeminZhang, XinsongLi*, Functional vesicles formed by anticancerdrugassembly,Bioorganic & Medicinal Chemistry Letters25 (2015) 188–191

18.ZhipingFan, Yemin Zhang,Xinsong Li*, BienzymaticallyCrosslinked Gelatin/Hyaluronic acidInterpenetrating Network HydrogelsWu, Yang;Ji, Jingkai; Yang,Ran; Zhang, Xiaoqiang; Li, Yuanhui; Pu, Yuepu; Li,Xinsong, Galactosylated2-hydroxypropyl methacrylamide-s-3-guanidinopropylmethacrylamide copolymer assmall hairpin RNA carrier for inhibiting humantelomerase reverse transcriptaseexpression, Journal of Gene Medicine, 2014,16(5-6): 109-121.

21.Yang Wu, Jinkai Ji, XinsongLi*, et al.,Galactosylated Poly(ethylene glycol)Methacrylate-st-3-GuanidinopropylMethacrylamide Copolymers as siRNA Carriersfor Inhibiting Survivin Expression in vitro and in vivo, Journal of DrugTargeting, 2014,22(4): 352-364.

22.Wang, XT ; Dai, Y  ; Zhao,S  ; Tang,JX  ; Li, HJ ; Xing, YT ; Qu, GL; Li, XS  ; Dai, JR ; Zhu,YC ,PAMAM-Lys,a Novel Vaccine Delivery Vector, Enhances theProtective Effects of the SjC23DNA Vaccine against Schistosoma japonicumInfection, PLoS, 2014;9(1):e86578,DOI: 10.1371/journal.pone.0086578.

23.Cai Wen, Lingling Lu,XinsongLi*, An IPN Biohydrogel of Gelatin and Gellan Gum by using CombinationofEnzymatic and Ionic Crosslinking Approaches, PolymerInternational,2014,63:1643-9.

24.Yan Mei, Chen Yao, XinsongLi*,A simple approach to constructing antibacterialand anti-biofoulingnanofibrous membranes, Biofouling, 2014,30(3): 313-322

25.Zongzhe Zhu, XinsongLi,Silicone hydrogels based on a novelamphiphilicpoly(2-methyl-2-oxazoline)-b-poly(dimethyl siloxane) copolymer,Journal ofApplied Polymer Science, online, 2014, 131(3): ?? DOI:10.1002/app.39867

26.Cai Wen, Lingling Lu, XinsongLi*,Mechanically Robust Gelatin-Alginate IPN Hydrogels by a Combination ofEnzymaticand Ionic Crosslinking Approaches, Macromolecular Materials andEngineering,2014, 299(4): 504-13.

27.Yang Wu, Jinkai Ji, XinsongLi*,et al., Guanidinylated 3-gluconamidopropylmethacrylamide-s-3-aminopropylmethacrylamide copolymer as siRNA carriers forinhibiting human telomerasereverse transcriptase expression, Drug delivery,2013;20(7):296-305.

28.Yan Mei, Zhiming Wang,XinsongLi*, Improving filtration performance of electrospun nanofiber mats byabimodal method, Journal of Applied Polymer Science, 2013, 128(2):1089–1094.

29.Xinsong Li*, Zhu Qin, etal.,Improvement of transfection efficiency by galactosylated N-3-guanidinopropylmethacrylamide-co-poly(ethyleneglycol)methacrylatecopolymer,European Polymer Journal, 2013, 49(10): 2884–2894

30.Yan Mei, Chen Yao, KaiFan,Xinsong Li, Surface modification of polyacrylonitrile nanofibrousmembraneswith superior antibacterial and easy-cleaning properties throughhydrophilicflexible spacers, Journal of Membrane Science, Journal ofMembraneScience, 2012, 417–418,20–27.

31.Zhu Qin, Wei Liu, Liang GuoandXinsong Li, Studies on GuanidinatedN-3-AminopropylMethacrylamide-N-2-Hydroxypropyl Methacrylamide Copolymers asGene DeliveryCarrier, Journal of Biomaterials Science-Polymer Edition, 2012,23: 133–152.

32.Zhu Qin, Wei Liu, Liang GuoandXinsong Li, Galactosylated N-2-Hydroxypropyl Methacrylamide-b-N-3-Guanidinopropyl Methacrylamide Block Copolymers as Hepatocyte-TargetingGene Carriers, Bioconjugate Chemistry, 2011, 22 (8), 1503–1512

33.Fuqian Sun, Chen Yao,TangyingSong, Xinsong Li, Fabricationofpoly(vinylidenefluoride-co-hexafluoropropylene) nanofiber yarns byconjugateelectrospinning, The Journal of the Textile Institute, 2011, 102(7):633-638.

34.Jingjing Wang, XinsongLi,Enhancing protein resistance of hydrogels based onpoly(2-hydroxyethylmethacrylate) and poly(2-methacryloyloxyethylphosphorylcholine) withinterpenetrating network structure, Journal of AppliedPolymer Science, 2011,121(6):3347-3352

35.Jinku Xu, Xinsong Li,FuqianSun, In vitro and in vivo Evaluation of Fumarate Ketotifen-LoadedSiliconeHydrogel Contact Lenses for Ocular Drug Delivery, Drug Delivery, 2011;18(2):150–158.

36.Jingjing Wang, XinsongLi,Interpenetrating polymer network hydrogels based on siliconeandpoly(2-methacryloyloxyethyl phosphorylcholine)Polymersfor Advanced Technologies, 2011,22(12): 2091–2095.

37.Jinku Xu, Xinsong Li,FuqianSun, Cyclodextrin-containing hydrogels for contact lenses as a platformof drugincorporation and release, Acta Biomaterialia, 2010, 6, 486-493.

38.Jinku Xu, Xinsong Li,FuqianSun, Preparation and Evaluation of Contact Lens Vehicle for PuerarinDelivery,Journal of Biomaterials Science-Polymer Edition, 2010,21(3), 271-288.

39.Jinku Xu, Xinsong Li, FuqianSun,Peiting Cao , pPVA Hydrogel Membrane Containing β-cyclodextrin forEnhancedLoading and Sustained Release of Ocular Therapeutics, Journal ofBiomaterialsScience-Polymer Edition, 2010, 21:1023-1038.

40.Jingjing Wang, FuqianSun,Xinsong Li,Preparation and characterization of interpenetrating polymernetworksilicone hydrogels with high oxygen permeability, JOURNAL OF APPLIEDPOLYMERSCIENCE, 2010, 116(5): 2749-2757.

41.Jingjing Wang, FuqianSun,Xinsong Li, Preparation and Antidehydration of Interpenetrating Polymer NetworkHydrogelsBased on 2-Hydroxyethyl Methacrylate and N-Vinyl-2-pyrrolidone,JOURNAL OFAPPLIED POLYMER SCIENCE, 2010, 117, 1851–1858.

42.Chen Yao, Xinsong Li,TangyingSong, Yunhui Li, Yuepu Pu, Biodegradable nanofibrous membrane ofzein/silkfibroin by electrospinning, Polymer International, 2009, 58(4),396-402.

43.Tang-ying Song, ChenYao,Xinsong Li, Preparation and Characterization of Zein andZein/Poly-L-lactide(PLLA) Continuous Nanofiber Yarns, JOURNAL OF APPLIEDPOLYMER SCIENCE,2009,114(4), 2079-2086

44.Yao, Chen;Li, Xinsong; Neoh, K.G.; Shi, Zhilong; Kang, E. T.,Antibacterial activities of surface modifiedelectrospun poly(vinylidenefluoride-co-hexafluoropropylene) (PVDF-HFP) fibrousmembranes, Applied SurfaceScience, 2009, 255(6),3854-3858.

45.Fu GD, Lei JY, Yao C, Li XS,YaoF, Nie SZ, Kang ET, Neoh, KG, Core-sheath nanofibers from combined atomtransferradical polymerization and electrospinning, MACROMOLECULES, 2008,41(18),6854-6858.

46.Yao, C; Li, XS; Neoh,KG,Surface modification and antibacterial activity of electrospunpolyurethanefibrous membranes with quaternary ammonium moieties, JOURNAL OFMEMBRANESCIENCE, 2008, 320(1-2), 259-267.

47.Fu,GD;Yao,F;Li,ZG,Li,XS,Solventresistant antibacterial microfibers of self-quaternizedblockcopolymers from atom transfer radical polymerization andelectrospinning,JOURNAL OF MATERIALS CHEMISTRY, 2008, 18(8), 859-867.

48.Zhiming Li,Feng Shan, JiangongWei, Jun Yang, Xinsong Li andXinling Wang, High ionic conductive PVDF-basedfibrous electrolytes,Journal of Solid State Electrochemistry,2008,12(12),1629-1635

49.Li XS, Yao C, Sun FQ, SongTY,Li YH, Pu YP, Conjugate electrospinning of continuous nanofiber yarn ofpoly(L-lactide)/nanotricalciumphosphate nanocomposite, JOURNAL OF APPLIEDPOLYMER SCIENCE, 2008, 107(6),3756-3764.

50.Chen Yao, Li Xinsong,SongTangying, Electrospinning and Crosslinking of Zein Nanofiber Mats, JournalofApplied Polymer Science, 2007, 103(1), 380–385.

51.Chen Yao, Li Xinsong,SongTangying, Fabrication of zein/hyaluronic acid fibrous membranesbyelectrospinning, Journal of Biomaterials Science-Polymerization Edition,2007,18 (6), 731-742.

52.LiXinsong, NieGuangyu.Nano-porous ultra-high specific surface ultrafine fibers(coverarticle). Chinese Science Bulletin, 2004, 49(22): 2368-2371.

53.Deng J, Li XS, Wang ZM, etal.An observation on the microphase separation ofpoly(methylmethacrylate)-block-polystyrene copolymer, CHINESE CHEM LETT,2001,12 (5),467-470.

54.Li XS, Wang GC, He BL,Entanglementof polymer chains in concentrated region by fluorescence probetechnique,CHINESE CHEM LETT, 1999, 10 (9), 795-798.

55.Li XS, Wang GC, HeBL,Intrachain and interchain interactions in polystyrene: Dilute andsemidilutesolutions, CHINESE CHEM LETT, 1999, 10 (11), 961-964.

56.Li, Xinsong;Wang, Guochang;He,Binlin,An observation on excimer formation in pyrenyl-labelledpolystyrene:concentrated solution and solvent-plasticized film, PolymerInternational,1999,48(8), 630-632.

57.Li XS, Wang GC, He BL, Astudyon the concentration dependence of excimer formation in pyrenyllabelledpolystyrene solutions, POLYM INT, 1999,48 (7), 529-531.

58.Shi Jinyuan, Wang Haifang,WuXiaohong, Li Xinsong, Liu Yuanfang, Li Kun, Luo Xiangyang, Wang Jianjun,LiuKexin, Genotoxicity of low-dose primicarb studied by acceleratormassspectrometry, Chinese Science Bulletin(Chinese), 1997, 42(15), 1675.

59.Li XS, Wang HF, Shi JY, WangXY,Liu YF, Li K, LU XY, Wang JJ, iu KX, Guo ZY, Genotoxicity study on nicotineandnicotine-derived nitrosamine by accelerator mass spectrometry,Radiocarbon,1996, 38(2), 347-353

60.He, Bing-Lin; Wang, Guo-Chang;Li,Xin-Song, Photophysical study of pyrene-labelled St/DVB copolymers, ScienceinChina, Series B: Chemistry, Life Sciences & Earth Sciences, 1994,37(5),513-517.

61.LiXinsong, et al., A study onDNA adduction with nicotine-derived nitrosamine by accelerator massspectrometry, Chinese Chemical Letters, 1994, 5(10), 873.


Invited Lecture:

  1. 邀请报告:纳米纤维及其在生物医学和工程领域的应用,20111011日,南开大学

  2. 邀请报告:水凝胶药物释放系统的研究,中国第13届生物医学工程生物材料年会,20111012-15日,天津

  3. 邀请报告:  Biomacromolecular Hydrogels with Interpenetrating Network Structure, Symposium of 2012 international symposium of matreials on regenerative medicine, Taibei, Taiwan, 2012, Aug. 29-31

  4. 邀请报告: Hydrogel Biomaterials with Interpenetrating Network Structure, Invited lecture, Changgung University, Taiwan, 2012, Aug. 31

  5. 邀请报告:组织工程支架: 纳米纤维或水凝胶? 邀请报告,北京大学生物医学工程系, 2012,9.12

  6. 邀请报告: SYNTHETIC HYDROGELS for OPTHAMIC APPLICATIONS, Symposium of 2010 International Symposium of Materials on Regenerative Medicine, Taiwan.

  7. 邀请报告:从纳米纤维膜到纳米纤维长纱,2007811-15日,中国化学会25届年会,长春

  8. 邀请报告:从纳米纤维膜到纳米纤维长纱,2007816日,北京化学研究所