The long-term goal of our research is to understand the mechanism of renal in flammation and fibrosis, and to find the novel non-invasive biomarkers for kidney disease. The current focus is the role of extracellular vesicle in kidney injury, and its potential as therapeutic vector in kidney disease. Our onging work includes extracellular vesicles in the injury and repair of tubular epithelial cell and its role in spreading injury signal to neighbor and remote cells, and also the macrophage pattern recognition receptor, Mincle in renal inflammation.

1.2017 Jiangsu Province Medical Youth Talent

2.2015 New technology award of Health department, Jiangsu Province

3.2013 New technology award of Health department, Jiangsu Province

SELETED PUBLICATIONS：

1.TangTT, Wang B, Wu M, Li ZL, Feng Y, Cao JY, Yin D, Liu H, Tang RN, Crowley SD, LvLL*, Liu BC*. Extracellular vesicle–encapsulated IL-10as novel nanotherapeutics against ischemic AKI. Sci. Adv. 2020; 6 : eaaz0748 (共同通讯， IF14.136)

2.TangTT, Wang B, Li ZL, Wen Y, Feng ST, Wu M, Liu D, Cao JY, Yin Q, Yin D, Fu YQ,Gao YM, Ding ZY, Qian JY, Wu QL, Lv LL*, Liu BC*. Kim-1 Targeted ExtracellularVesicles: A New Therapeutic Platform for RNAi to Treat AKI. J Am Soc Nephrol.2021 Oct;32(10):2467-2483. (共同通讯，IF 10.121)

3.LvLL#*, Wang C#, Li ZL#, Cao JY, Zhong X, Feng Y, Chen J, Tang TT, Ni HF, Wu QL,Wang B, Lan HY, Liu BC. SAP130 released by damaged tubule drivesnecroinflammation via miRNA-219c/Mincle signaling in acute kidney injury. CellDeath Dis. 2021 Sep 23;12(10):866.(共同一作/独立通讯，IF8.469)

4.LvLL*#, Feng Y#, Wu M, Wang B, Li ZL, Zhong X, Wu WJ, Chen J, Ni HF, Tang TT,Tang RN, Lan HY, Liu BC*. Exosomal miRNA-19b-3p of tubular epithelial cellspromotes M1 macrophage activation in kidney injury. Cell Death Differ. 2020 Jan27 (1): 210-226, (共同通讯，IF 15.828)

5.LiZL#, Lv LL#*, Tang TT, Wang B, Feng Y, Zhou LT, Cao JY, Tang RN, Wu M, Liu H,Crowley SD, Liu BC*. HIF-1a inducing exosomal microRNA-23a expression mediatesthe cross-talk between tubular epithelial cells and macrophages intubulointerstitial inflammation. Kidney Int. 2019 Feb;95(2):388-404.(共同一作/共同通讯，IF10.612)

6.LvLL, Feng Y, Wen Y, Wu WJ,Ni HF, Li ZL,Zhou LT, Wang B, Zhang JD, Crowley SD, Liu BC#. Exosomal CCL2 from tubularepithelial cells is critical for albumin induced tubulointerstitialinflammation. J Am Soc Nephrol. 2018 Mar;29(3):919-935.（IF 10.121 ）

7.LvLL, Tang P, Li CJ, You YK, Li JH, Huang XR, Ni J, Feng M, Liu BC#, Lan HY#. Thepattern recognition receptor, Mincle, is essential for maintaining the M1macrophage phenotype in acute renal inflammation. Kidney Int. 2017Mar;91(3):587-602.（IF 10.612 ）

8.FengY, Zhong X, Tang TT, Wang C, Wang LT, Li ZL, Ni HF, Wang B, Wu M, Liu D, Liu H,Tang RN, Liu BC*, Lv LL*. Rab27a dependent exosome releasing participated inalbumin handling as a coordinated approach to lysosome in kidney disease. CellDeath Dis. 2020 Jul 8;11(7):513.(共同通讯，IF8.469)

9.TangTT, Lv LL*, Wang B, Cao JY, Feng Y, Li ZL, Wu M, Wang FM, Wen Y, Zhou LT, NiHF, Chen PS, Gu N, Crowley SD, Liu BC*. Employing macrophage-derivedmicrovesicle for kidney-targeted delivery of dexamethasone: An efficienttherapeutic strategy against renal inflammation and fibrosis therapeuticstrategy against renal inflammation and fibrosis. Theranostics. 2019 Jul9;9(16):4740-4755(共同通讯，IF11.556)

10.TangTT, Lv LL*, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD, Liu BC*.Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibitingcathepsin mediated NLRP3 inflammasome activation. Cell Death Dis. 2018 Mar2;9(3):351. (共同通讯，IF 8.469 )