主要围绕“噪声的听觉系统内/外损伤效应及机制”、“认知/情绪行为异常的神经机制”这两大研究方向展开系统研究，所获部分数据已发表于Environ Health Perspect、ELife等高影响因子杂志，并已获多项国家自然科学基金面上项目及国际合作项目支持。
近年承担科研项目情况：
主持并完成国家自然科学基金面上项目一项（KCNQ1 通道在胰腺β细胞内分泌功能中的作用，2012-2014）；
现主持国家自然科学基金面上项目两项（噪声性听力损失对认知功能的损伤效应及其海马相关机制研究，2017-2020；小胶质细胞在噪声性听力 小鼠认知损伤中的作用及机制研究，2021-2023）；
现参与国家自然科学基金国际重大合作研究项目一项（听觉障碍疾病的多模态磁共振成像研究，2016-2020）。
曾为主参与国家自然科学基金面上项目三项（都已结题）。
2015年至2020年发表的SCI论文：
1.Zhuang H, Yang J, Huang Z, LiuH, Li X, Zhang H, Wang J, Yu S, Liu K, Liu R, Bi M, Wang J, Salvi RJ, Hu B,Teng G, Liu L: Accelerated age-related decline in hippocampalneurogenesis in mice with noise-induced hearing loss is associated withhippocampal microglial degeneration. Aging (Albany NY) 2020, 12:19493-519.
2.Kim MJ, Haroon S, Chen GD, DingD, Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I,Evans K, Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S:Increased burden of mitochondrial DNA deletions and point mutations inearly-onset age-related hearing loss in mitochondrial mutator mice. ExpGerontol 2019, 125:110675.
3.Liu L, Fang C, Yang J, Zhang H, Huang Y, Xuan C, Wang Y, Li S, Sha J, ZhaM, Guo M: The effect of noise exposure on insulin sensitivity in mice may bemediated by the JNK/IRS1 pathway. Environmental health and preventive medicine2018, 23:6.
4.Liu L, Huang Y, Fang C, Zhang H, Yang J, Xuan C, Wang F, Lu H, Cao S,Wang Y, Li S, Sha J, Zha M, Guo M, Wang J: Chronic noise-exposure exacerbatesinsulin resistance and promotes the manifestations of the type 2 diabetes in ahigh-fat diet mouse model. PloS one 2018, 13:e0195411.
5.Liu L, Xuan C, Shen P, He T, Chang Y, Shi L, Tao S, Yu Z, Brown RE, WangJ: Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long AfterEstablishment of Noise-Induced Hearing Loss in CBA Mice. Frontiers in systemsneuroscience 2018, 12:35.
6.Chen H, Shi L, Liu L,Yin S, Aiken S, Wang J: Noise-induced Cochlear Synaptopathy and Signal ProcessingDisorders. Neuroscience 2018.
7.Liu L, Shen P, He T, Chang Y, Shi L, Tao S, Li X, Xun Q, Guo X, Yu Z,Wang J: Noise induced hearing loss impairs spatial learning/memory andhippocampal neurogenesis in mice. Scientific reports 2016, 6:20374.
8.Liu L, Wang F, Lu H, Cao S, Du Z, Wang Y, Feng X, Gao Y, Zha M, Guo M,Sun Z, Wang J: Effects of Noise Exposure on Systemic and Tissue-Level Markersof Glucose Homeostasis and Insulin Resistance in Male Mice. Environ HealthPerspect 2016.
9.Shi L, Chang Y, Li X, Aiken SJ,LiuL, Wang J: Coding Deficits in Noise-Induced Hidden Hearing Loss MayStem from Incomplete Repair of Ribbon Synapses in the Cochlea. Frontiers inneuroscience 2016, 10:231.
10.Shi L, Chang Y, Li X, Aiken S, Liu L, Wang J: Cochlear Synaptopathyand Noise-Induced Hidden Hearing Loss. Neural plasticity 2016, 2016:6143164.
11.Chen YC, Li X, Liu L, Wang J, Lu CQ, Yang M, JiaoY, Zang FC, Radziwon K, Chen GD, Sun W, Krishnan Muthaiah VP, Salvi R, Teng GJ:Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity inauditory-limbic-arousal-cerebellar network. eLife 2015, 4:e06576.
12.Jie H, Tao S, Liu L, Xia L, Charko A, Yu Z, BanceM, Yin S, Robertson GS, Wang J: Cochlear protection against cisplatin by viraltransfection of X-linked inhibitor of apoptosis protein across round windowmembrane. Gene therapy 2015, 22:546-52.
13.Shi L, Guo X, Shen P, Liu L, Tao S, Li X, Song Q, Yu Z,Yin S, Wang J: Noise-induced damage to ribbon synapses without permanentthreshold shifts in neonatal mice. Neuroscience 2015, 304:368-77.
14.Zhang GY, Yang M, Liu B, Huang ZC, Chen H, Zhang PP, Li J, Chen JY, LiuLJ, Wang J, Teng GJ: Changes in the default mode networks ofindividuals with long-term unilateral sensorineural hearing loss. Neuroscience2015, 285:333-42.