1、Noise-inducedhearing loss and cognitive impairment:

Epidemiological evidences suggest that hearing lossis likely to be a promoting factor in the development of cognitive impairment.Noise-induced hearing loss is the most common type of acquired hearing loss.Hippocampus is a crucial brain region for learning and memory in mammals. Myresearch interests focus on exploring of the relationship between noise-inducedhearing loss and cognitive impairment and the underlying hippocampus-relatedmechanisms.

2、Noise-exposureand temporal encoding of cochlear:

Noise exposure at low levels or low doses candamage hair cell afferent ribbon synapses without causing permanent thresholdshifts and result in impaired cochlear function especially the ability oftemporal encoding. I am interested in understanding the potential underlyingmechanisms.

2016, Most Popular Teacher of Medical College, SoutheastUniversity

2015, First Prize in Teaching show, ChineseEducation Society

2015, Special Prize in Teaching competitionEducation Working Committee of JiangSuprovince, China

2014, ZhongNan-Group Teaching Grants, SoutheastUniversity

2013, Second Class in Teaching competition, SoutheastUniversity

2010, Second Class Award for Advance in Science andTechnology, Educational Ministry of China

2009, HengShun Teaching Grants, SoutheastUniversity

2008, First Prize of Outstanding Individual in theUndergraduate Teaching Level Evaluation, Southeast University

2008, Second Class Award for Teaching, SoutheastUniversity

2003, Government Teaching Grants, SoutheastUniversity

2003, First Class in Teaching competition, SoutheastUniversity

2001, Second Class in Teaching competition, SoutheastUniversity

RESEARCH SUPPORT（2012-2018）：

2020-2023, PI, National Natural Science Foundation of China, 570,000RMB

2017-2020, PI, National Natural Science Foundation of China, 580,000RMB

2016-2020, Parter, Projects of International Cooperation NSFC, 2,820,000RMB

2013-2016, Main parter, National Natural Science Foundation of China,700,000RMB

2012-2014, PI, National Natural Science Foundation of China, 230,000RMB

2012-2014, Main parter, National Natural Science Foundation of China,580,000RMB

2011-2013, PI, Advanced Research Foundation of Southeast University, 20,000RMB

PUBLICATIONS （2012-2019）：

[1] Kim MJ, Haroon S, Chen GD, Ding D,Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K,Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S: Increasedburden of mitochondrial DNA deletions and point mutations in early-onsetage-related hearing loss in mitochondrial mutator mice. Exp Gerontol 2019,125:110675.

[2] LiuLJ, Huang Y, Fang C, Zhang HY, Yang J, Xuan CY, Wang FF, Lu HY, Cao SF, WangYF, Li SW, Sha J, Zha MM, Guo M, Wang J: Chronic noise-exposure exacerbatesinsulin resistance and promotes the manifestations of the type 2 diabetes in ahigh-fat diet mouse model. PloS one 2018, 13:16.

[3] Liu LJ, Fang C, Yang J, Zhang HY, Huang Y, XuanCY, Wang YF, Li SW, Sha J, Zha MM, Guo M: The effect of noise exposure oninsulin sensitivity in mice may be mediated by the JNK/IRS1 pathway.Environmental health and preventive medicine 2018, 23:8.

[4] Liu L, Xuan C, Shen P, He T, Chang Y, Shi L,Tao S, Yu Z, Brown RE, Wang J: Hippocampal Mechanisms Underlying Impairment inSpatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBAMice. Frontiers in systems neuroscience 2018, 12:35.

[5] Liu L, Fang C, Yang J, Zhang H, Huang Y, XuanC, Wang Y, Li S, Sha J, Zha M, Guo M: The effect of noise exposure on insulinsensitivity in mice may be mediated by the JNK/IRS1 pathway. Environmentalhealth and preventive medicine 2018, 23:6.

[6] Chen H, Shi L, Liu L, Yin S, Aiken S, Wang J:Noise-induced Cochlear Synaptopathy and Signal Processing Disorders.Neuroscience 2018.

[7] Zhang GY, Yang M, Liu B, Huang ZC, Li J, ChenJY, Chen H, Zhang PP, Liu LJ, Wang J, Teng GJ: Changes of the directional brainnetworks related with brain plasticity in patients with long-term unilateralsensorineural hearing loss. Neuroscience 2016, 313:149-61.

[8] Song Q, Shen P, Li X, Shi L, Liu L, Wang J, YuZ, Stephen K, Aiken S, Yin S: Coding deficits in hidden hearing loss induced bynoise: the nature and impacts. Scientific reports 2016, 6:25200.

[9] Shi LJ, Chang Y, Li XW, Aiken SJ, Liu LJ, WangJ: Coding Deficits in Noise-Induced Hidden Hearing Loss May Stem fromIncomplete Repair of Ribbon Synapses in the Cochlea. Frontiers in neuroscience2016, 10:6.

[10] Shi L, Chang Y, Li X, Aiken S, Liu L, Wang J:Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss. Neural plasticity2016, 2016:6143164.

[11] Liu LJ, Wang FF, Lu HY, Cao SF, Du ZW, WangYF, Feng X, Gao Y, Zha MM, Guo M, Sun ZL, Wang J: Effects of Noise Exposure onSystemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistancein Male Mice. Environ Health Perspect 2016, 124:1390-8.

[12] Liu LJ, Shen P, He TT, Chang Y, Shi LJ, Tao S,Li XW, Xun QY, Guo XJ, Yu ZP, Wang J: Noise induced hearing loss impairsspatial learning/memory and hippocampal neurogenesis in mice. Scientificreports 2016, 6:9.

[13] Zhang GY, Yang M, Liu B, Huang ZC, Chen H,Zhang PP, Li J, Chen JY, Liu LJ, Wang J, Teng GJ: Changes in the default modenetworks of individuals with long-term unilateral sensorineural hearing loss.Neuroscience 2015, 285:333-42.

[14]Shi L, Guo X, Shen P, Liu L, Tao S, Li X, SongQ, Yu Z, Yin S, Wang J: Noise-induced damage to ribbon synapses withoutpermanent threshold shifts in neonatal mice. Neuroscience 2015, 304:368-77.

[15] Jie H, Tao S, Liu L, Xia L, Charko A, Yu Z,Bance M, Yin S, Robertson GS, Wang J: Cochlear protection against cisplatin byviral transfection of X-linked inhibitor of apoptosis protein across roundwindow membrane. Gene therapy 2015, 22:546-52.

[16] Chen YC, Li X, Liu L, Wang J, Lu CQ, Yang M,Jiao Y, Zang FC, Radziwon K, Chen GD, Sun W, Krishnan Muthaiah VP, Salvi R,Teng GJ: Tinnitus and hyperacusis involve hyperactivity and enhancedconnectivity in auditory-limbic-arousal-cerebellar network. eLife 2015,4:e06576.

[17] Liu LJ, Wang FF, Lu HY, Ren XM, Zou JH:Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulatedinsulin secretion and increases glucagon-like peptide-1 level in mice. Islets2014, 6:8.

[18] Shi L, Liu L, He T, Guo X, Yu Z, Yin S, WangJ: Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-inducedsilent damage. PloS one 2013, 8:e81566.

[19] Liu LJ, Wang H, Shi LJ, Almuklass A, He TT,Aiken S, Bance M, Yin SK, Wang J: Silent Damage of Noise on Cochlear AfferentInnervation in Guinea Pigs and the Impact on Temporal Processing. PloS one2012, 7:11.