I devote myself to my career on theclinical, scientific research, andteaching work of orthopaedics (spine surgery). In the clinical research, myteam and I mainly focused on the improvements of treatment therapies(especially for minimally invasive therapies) for intervertebral discdegeneration diseases. We have followed up large samples and analyzed the riskfactors for reoperation after microendoscopic discectomy, which is valuable forpatient selection before surgery and is conducive to improve the clinical effects.In the basic research, we mainly focused on the etiology and molecularbiological repair of intervertebral disc degeneration diseases, and a thoroughexploration has been made. Now, more innovative research is underway, and more valuableresults and clinical transformations are expected.

2009 The Second Prize of Jiangsu Science and Technology Progress Award

2016 Research Funds of Jiangsu ProvincialCommission of Health and Family Planning

2016 National Natural Science Foundation of China

2016 Dedication Award of Zhongda Hospital, SoutheastUniversity

SelectedPublications

1.HongX, Zhang C, Wang F, Wu XT (2018) Large Cytoplasmic Vacuoles within NotochordalNucleus Pulposus Cells: A Possible Regulator of Intracellular Pressure ThatShapes the Cytoskeleton and Controls Proliferation. Cells Tissues Organs:1-7.doi:10.1159/000493258

2.HongX, Shi R, Wang YT, Liu L, Bao JP, Wu XT (2018) Lumbar disc herniation treatedby microendoscopic discectomy : Prognostic predictors of long-termpostoperative outcome. Orthopade. doi:10.1007/s00132-018-3624-6

3.HongXin; Liu Lei; Bao Jun-Ping; Shi Rui; Fan Yu-Dong; Wu Xiao-Tao*,Characterization and risk factors analysis for reoperation aftermicroendoscopic discectomy to treat lumbar disc herniation, Orthopedics, 2015,38(6): e490~6.

4.HongXin，WuXiao-tao*，ZhuangSu-yang，BaoJun-ping，ShiRui, New cage for posterior minimally invasive lumbar interbody fusion: a studyin vitro and in vivo. , Orthopaedic Surgery, 2014.2, 6(1): 47~53.

5.XinHong, Shu Yang, Yuntao Wang, Lei Zhu, Kun Wang, Xiaotao Wu: Long-termradiological changes and clinical effect after microendoscopic discectomy(MED): a cross-sectional study. Int J Clin Exp Med 2018;11(6):5729-5735.

6.XinHong, Christoph W Michalski, ALCAM is associated with chemiresistance and tumorcell adhesion in pancreatic cancer. Journal of surgical oncology2010;101:564-569

7.SunHH, Hong X, Liu B, Cui JQ, Zhou ZM, Xie XH, Wu XT (2018) Survival analysis ofpatients with spinal chordomas. Neurosurg Rev. doi:10.1007/s10143-018-0968-7（Co-first author）

8.WangK, Hong X, Zhou BY, Bao JP, Xie XH, Wang F, Wu XT (2015) Evaluation oftransforaminal endoscopic lumbar discectomy in the treatment of lumbar discherniation. Int Orthop 39 (8):1599-1604. doi:10.1007/s00264-015-2747-1（Co-first author）

9.Xie,Z. Y; Zhang, C; Chen, L; Zhang, C; Zhang, C; Cai, F; Wang, X. H; Shi, R;Sinkemani, A; Yu, H. M; Hong, X*; Wu, X. T*, Acid-Sensing Ion Channel 1aRegulates Fate of Rat Nucleus Pulposus Cells in Acid Stimulus ThroughEndoplasmic Reticulum Stress, Biores Open Access, 2018.2.16, 7(1): 2~9. (Correspondingauthor)

10.ChenL, Liu L, Xie ZY, Wang F, Sinkemani A, Zhang C, Wang XH, Wang K, Hong X, Wu XT(2018) Endoplasmic Reticulum Stress Facilitates the Survival and Proliferationof Nucleus Pulposus Cells in TNF-alpha Stimulus by Activating Unfolded ProteinResponse. DNA Cell Biol 37 (4):347-358. doi:10.1089/dna.2017.4029 (Correspondingauthor)

11.XieZY, Chen L, Wang F, Liu L, Zhang C, Wang K, Cai F, Sinkemanni A, Hong X, Wu XT(2017) Endoplasmic Reticulum Stress Is Involved in Nucleus PulposusDegeneration and Attenuates Low pH-Induced Apoptosis of Rat Nucleus PulposusCells. DNA Cell Biol 36 (8):627-637. doi:10.1089/dna.2017.3736 (Correspondingauthor)