Research Fields

stem cells, biomedical materials, tissue engineering,regenerative medicine, cartilage, silk

Honor Reward
Academic Achievements


PUBLICATIONS (peer-reviewed papers)


§Sheng RW, Chen JL,  Wang HM, Luo YF, Liu J, Chen ZX, Mo QY, Chi JY, Ling C, Tan X, Yao QQ, Zhang W*. Nanosilicate-reinforced  silk fibroin hydrogel for endogenous regeneration of both cartilage and  subchondral bone. Adv Healthc Mater.2022:e2200602. (Corresponding author; IF=11.092) https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202200602


§Cao ZC, Wang HM,  Chen JL, Zhang YN, Mo QY, Zhang P, Wang MY, Liu HY, Bao XY, Sun YZ, Zhang W*, Yao QQ*. Silk-based hydrogel incorporated with  metal-organic framework nanozymes for enhanced osteochondral regeneration.Bioact Mater.2023, 20:221-242. (Co-corresponding  author; IF=16.874)

§https://www.sciencedirect.com/science/article/pii/S2452199X22002468


§Zhang W*, Zhang YN, Li XL, Cao ZC, Mo QY, Sheng RW,  Ling C, Chi JY, Yao QQ*, Chen JL*, Wang HM*. Multifunctional polyphenol-based silk  hydrogel alleviates oxidative stress and enhances endogenous regeneration of  osteochondral defects. Mater Today Bio,  2022, 14:100251. (First & Corresponding  author; IF=10.761)

§https://www.sciencedirect.com/science/article/pii/S2590006422000497


§Chen ZX#, Zhang W#,  Wang MY, Backman LJ, Chen JL*. Effects of zinc, magnesium and iron ions on  bone tissue engineering. ACS Biomater  Sci Eng, 2022, 8(6), 2321-2335. (Co-first  author; IF=5.395)


§Mo QY#, Zhang W#,  Zhu AJ, Backman LJ, Chen JL*. Regulation of osteogenicdifferentiation by the  pro-inflammatory cytokines IL-1β and TNF-α: Current conclusions and  controversies. Human Cell,  2022,35(4), 957-971. (Co-first author; IF=4.374)


§Zhang AN#, Zhang W#,  Backman LJ, Chen JL*. Advances in Regulatory Strategies of Differentiating  Stem Cells towards Keratocytes. Stem Cells Int 2022. (Co-first author; IF=5.131)


§Chen JL*, Mo QY, Sheng RW, Zhu AJ, Ling C,  Luo YF, Zhang AN, Chen ZX, Yao QQ, Cai ZY*, Zhang W*. The application  of human periodontal ligament stem cells and biomimetic silk scaffold for in  situ tendon regeneration. Stem Cell Res  Ther. 2021,12:596. (Corresponding  author; IF=8.098)

§https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02661-7


§Liu HY, Chen JL, Qiao S, Zhang W*. Carbon-Based  Nanomaterials for Bone and Cartilage Regeneration: A Review. ACS Biomater Sci Eng.2021, 7, 10, 4718–4735.(Corresponding author; IF=5.395)


§Zhang W*, Zhang YN, Zhang AN, Ling C, Sheng RW, Li XL,  Yao QQ*, Chen JL*.  Enzymatically  Crosslinked Silk-Nanosilicate Reinforced Hydrogel with Dual-Lineage  Bioactivity for Osteochondral Tissue Engineering. Mat  Sci Eng C-Mater. 2021,127:112215. (First & Corresponding author; IF=8.457)

§https://www.sciencedirect.com/science/article/pii/S0928493121003556


§Wang YF, Zhang  W*, Yao QQ*. Copper-Based  Biomaterials for Bone and Cartilage Tissue Engineering. J Orthop Transl2021, 29:60-71. (Co-corresponding author; IF=4.889)


§Zhang L#, Zhang W#, Hu YJ, Fei Y, Liu HY, Huang ZZ, Wang CL, Ruan DF, Heng BC, Chen WS,  Shen WL*. Systematic  review of silk scaffolds in musculoskeletal tissue engineering applications  in the recent decade. ACS Biomater Sci Eng.2021, 7(3), 817-840.(Co-first author; IF=5.395)

https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c01716


§Zhang W*, Chen JL, Qu ML, Backman  L, Zhang AN, Liu HY, Zhang XP, Zhou QJ*, Danielson  P*. Sustained  release of TPCA-1 from silk fibroin hydrogels preserves keratocytephenotype  and promotes corneal regeneration by inhibiting interleukin-1β signaling. Adv Healthc Mater.2020, 9(17), 2000591. (First & Corresponding  author; IF=11.092)

§https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.202000591


§Zhang W*, Ling C, Zhang AN, Liu HY, Jiang YJ, Li XL, Sheng RW, Yao QQ*, Chen JL*. An  all-silk-derived functional nanosphere matrix for sequential biomolecule  delivery and in situ osteochondral regeneration. Bioact Mater.2020, 5:832-843. (First & Corresponding author; IF=16.874)

§https://www.sciencedirect.com/science/article/pii/S2452199X20300852


§Zhang W*, Ling C, Liu HY,  Zhang AN, Mao L, Wang J, Chao J,Backman L, Yao  QQ*, Chen JL*. Tannic  Acid-Mediated Dual Peptide-Functionalized Scaffolds to Direct Stem Cell  Behavior and Osteochondral Regeneration. Chem Eng J.2020, 396:125232. (First & Corresponding  author; IF=16.744)

https://www.sciencedirect.com/science/article/pii/S1385894720312249


§Zhang W*, Ling C, Li XL, Sheng RW, Liu HY, Zhang AN, (First & Corresponding  author; IF=5.395)

§https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c01276


§Sheng RW, Jiang YJ, Backman LJ, Zhang W*, Chen JL*. The application of mechanical  stimulations in tendon tissue engineering. Stem Cells Int2020, 2020: 8824783.  (Co-corresponding author; IF=5.131)


§Zhang W, Robertson W, Zhao  JM, Chen WW, Xu JK*. Emerging trend in the pharmacotherapy of osteoarthritis.  Front Endocrinol. 2019, 10:431. (First author; IF=6.055)


§Zhang W, Li Y, Jiang DM, Xie SJ, Zeng MF, Chen JL, Chen  LK, Ouyang HW*, Zou XH*. Promotion of  Hernia Repair with High-Strength, Flexible, and Bioresorbable Silk Fibroin  Mesh in a Large Abdominal Hernia Model. ACS  Biomater Sci Eng.2018,  4, 2067−2080.(First author; IF=5.395)

§https://pubs.acs.org/doi/10.1021/acsbiomaterials.7b00666


§Chen JL#, Zhang W#,  Backman L, Kelk P, Danielson P*. Mechanical stress potentiates the differentiation  of periodontal ligament stem cells into keratocytes. Brit J Ophthalmol2018, 102:562–569. (Co-first author; IF=5.915) https://bjo.bmj.com/content/102/4/562.long


§Zhang W, Chen LK, Chen JL,  Wang LS, Gui XX, Ran JS, Xu GW, Zhao HS, Zeng MF, Ji JF, Qian L, Zhou JD,  Ouyang HW*, Zou XH*. Silk Fibroin Biomaterial Shows Safe and  Effective Wound Healing in Animal Models and a Randomized Controlled Clinical  Trial. Adv Healthc Mater2017, 6(10), 1700121.  (First author; IF=11.092,Front  cover; highlighted by Advanced Science News, and ChemistryViews.org)

§https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201770048


§Zhang W, Chen JL, Backman L, Malm A, Danielson P*. Surface Topography  and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix  Formation in a Biomimetic 3D Corneal Model. Adv Healthc Mater2017, 6(5), 1601238. (First author; IF=11.092,Front cover; highlighted by Advanced Science News)

§https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201770022


§Chen JL#, Zhang W#,  Kelk P, Backman L, Danielson P*. Substance P and patterned silk biomaterial stimulate periodontal  ligament stem cells to form corneal stroma in a bioengineered 3D model. Stem Cell Res Ther. 2017,8:260. (Co-first author; IF=8.098)  https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0715-y


§Zhang W, Ouyang HW, Dass CR, Xu JK*. Current research on  pharmacologic and regenerative therapies for osteoarthritis. Bone Research2016, 4: 15040. (First author; IF=13.362; ESI Top 1% Cited)

§https://www.nature.com/articles/boneres201540


§Zhang W,  Heng BC, Jiang YZ*, Ouyang HW*. Clinical Translation of Autologous Cell-Based  Tissue Engineering Techniques as Class Three Therapeutics in China- Taking  Cartilage Tissue Engineering as an Example. Journal of Orthopaedic Translation2014,  2(2): 56-65. (First author; IF=4.889)


§Zhang W,  Chen JL, Tao JD, Jiang YZ, Hu CC, Huang L, Ji JF, Ouyang HW*. The use of type 1  collagen scaffold containing stromal cell-derived factor-1 to create a matrix  environment conducive to partial-thickness cartilage defects repair.  Biomaterials2013,  34(3):713-723. (First author; IF=15.304)

§https://www.sciencedirect.com/science/article/pii/S0142961212011489


§Zhang W,  Chen JL, Tao JD, Hu CC, Chen LK, Zhao HS, Xu GW, Heng BC, Ouyang HW*. The promotion of osteochondral repair by  combined intra-articular injection of parathyroid hormone- related protein  and implantation of a bi-layer collagen-silk scaffold. Biomaterials2013,  34(25):6046-6057. (First author; IF=15.304)

§https://www.sciencedirect.com/science/article/pii/S0142961213005292


§Zhang W,  Chen JL, Zhang SF, Ouyang HW*. Inhibitory function of parathyroid  hormone-related protein on chondrocyte hypertrophy: the implication for  articular cartilage repair. Arthritis Res Ther2012, 14(4):221. (First author; IF=5.607)


§Chen JL, Zhang W, Liu ZY, Zhu T,  Ouyang HW*. Characterization and comparison of post-natal rat Achilles  tendon-derived stem cells at different development stages. Sci Rep2016, 6: 22946. (IF=4.996)


§Chen JL, Zhang W, Liu ZY, Heng BC,  Ouyang HW*, Dai XS*. Physical regulation of stem cells  differentiation into teno-lineage: current strategies and future direction. Cell Tissue Res2014,  360(2):195-207. (IF=5.249)


§Chen JL*, Backman  L, Zhang W, Ling C, Danielson P*. Regulation of  keratocyte phenotype and cell behavior by substrate stiffness. ACS Biomater Sci Eng.2020, 6(9): 5162–5171.(IF=5.395)


§Chen JL, Zhang EC, Zhang W, Liu ZY,  Lu P, Zhu T, Yin Z, Backman LJ, Liu HH, Chen X, Ouyang HW*. Fos promotes early  stage teno-lineage differentiation of TSPCs in tendon. Stem Cells Transl Med2017,6(11):2009–2019 (IF=7.655)


§Jiang Y, Cai Y, Zhang W, Yin Z, Tuan  RS, Ouyang HW*. Human Cartilage-Derived Progenitor Cells  from Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Stem Cells Transl Med2016,  5(6):733-44 (IF=7.655)


§Zhang SF, Jiang YZ, Zhang W, Chen LK,  Tong T, Liu WL, Mu Q, Liu H, Ji JF, Ouyang HW, Zou XH*. Neonatal  Desensitization Supports Long-Term Survival and Functional Integration of Human  Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage  Without Immunosuppression. Stem Cells  Dev 2013, 22(1): 90-101. (IF=4.39)


§Jiang YZ, Chen LK, Zhang SF, Tong T, Zhang  W, Liu WL, Xu GW, Tuan RS, Heng BC, Crawford R, Xiao Y, Ouyang HW*. Incorporation of  bioactive polyvinylpyrrolidone -iodine within bilayered collagen 1 scaffolds  enhances the differentiation and subchondral osteogenesis of MSCs. Acta Biomater2013,  9(9):8089-98. (IF=10.633)


§Chen JL, Lan J, Liu DL, Backman L, Zhang  W, Zhou QJ, Danielson P*. Ascorbic Acid Promotes the Stemness of  Corneal Epithelial Stem/progenitor Cells and Accelerates Epithelial Wound  Healing in the Cornea. Stem Cells  Transl Med2017,6(5):1356-1365. (IF=7.655)


§Shen WL, Chen JL, Zhu T, Chen LK, Zhang W,  Fang Z, Heng BC, Yin Z, Chen X, Ji J, Chen W, Ouyang HW*. Intra-Articular  Injection of Human Meniscus Stem/Progenitor Cells Promotes Meniscus  Regeneration and Ameliorates Osteoarthritis through Stromal Cell-Derived  Factor-1/CXCR4-Mediated Homing. Stem  Cells Transl Med 2014, 3(3):387-94. (IF=7.655)


§Cai DD, Zhou FF, Zhang XZ, Mu Q, Li J, Zhang  W, Zhu SA, Jiang YZ, Shen WL, Zhang SF, Ouyang HW*.Silk-CS scaffold with  immuno-inhibition property for joint cartilage repair. Acta Biomater2017, 63:64-75. (IF=10.633)


§Zhang SF, Chen LK, Jiang YZ, Cai YZ, Xu GW,  Tong T, Zhang W, Wang LL, Ji JF, Shi PH, Ouyang HW*. Bi-layer  collagen/microporous electrospun nanofiber scaffold improves the  osteochondral regeneration. Acta  Biomater2013, 9(7):7236-47. (IF=10.633)


§Shen W, Chen X, Hu Y, Yin Z, Zhu T, Hu J,  Chen J, Zheng Z, Zhang W, Ran J, Heng BC, Ji J, Chen W, Ouyang HW*. Long-term effects of  knitted silk-collagen sponge scaffold on anterior cruciate ligament  reconstruction and osteoarthritis prevention. Biomaterials. 2014, 35(28):8154-63. (IF=15.304)



PATENTS

§Zhang W, Chen LK, Xie SJ. Collagen-based membrane for cartilagerepair: methods and application.  Publication number: ZL 2014 1 0499517.X

§Zhang W, Chen LK, Xu GW, Xuan TF. Bioactive factor-incorporatedtissue engineering scaffold for cartilage repair: methods and application. Publication number: ZL 2015 1 0808397.1



BOOKS

1. Biomaterials and Tissue Regeneration. 2021. People’s Medical Publishing House,China.(Book chapter)

2. Tissue Engineering.Trauma, burn and regenerative medicine. 2014. People’s Medical Publishing House,China.(Book chapter)

3. Biomaterials and regeneration.Regenerative Medicine: Basic and Clinical Research. 2013. People’s Medical Publishing House,China. (Book chapter)