研究方向

(1)非编码RNA在乳腺癌中的作用机制研究

(2)肿瘤耐药性分子标志物的识别



荣誉奖励

1、2020年东南大学奖教金

2中国抗癌协会科技奖三等奖

3、黑龙江省科技进步奖一等奖、二等奖等

4、黑龙江省高校科学技术奖一等奖

5、哈尔滨市自然科学技术学术成果奖论文类一等奖


学术成果

近五年主持课题:

1、国家自然科学基金面上项目“LncRNA HCP5编码蛋白调控14-3-3ζ促进三阴乳腺癌恶性进展的机制研究”(81972478),55万;

2、东南大学人才启动金“LncRNA HCP5 作为ceRNA竞争结合miR-219a-5p调控BIRC3促进三阴乳腺癌恶性进展的机制研究”,30万;

3、国家自然科学基金青年项目“miR-155/PU.1/TAL-1通路调控乳腺癌细胞生物学功能的机制研究”(81202074),23万;

4、黑龙江省自然科学基金“miR-155靶向PU.1在乳腺癌细胞中的作用机制研究”(QC2016118),5万;

5、哈尔滨市科技创新人才优秀学科带头人专项资金“LncRNA HCP5作为ceRNA竞争结合miR-155调控转录因子PU.1促进乳腺癌恶性进展的机制研究”(2016RAXYJ107),5万;

6、东南大学基础科研扶持项目(2242018K40024),负责人。

近五年发表论文:

1、Lihong Wang*, Tian Luan, Shunheng Zhou, Jing Lin, Yue Yang, Wei Liu, Xiao Tong, Wei Jiang*. LncRNA HCP5 promotes triple negative breast cancer     progression as a ceRNA to regulate BIRC3 by sponging miR‐219a‐5p. Cancer medicine. 2019 May26; 8(9):4389-4403.

2、Leiming Jiang, Xuexin Yu, Xueyan Ma, Haizhou Liu, Shunheng Zhou, Xu Zhou, Qianqian Meng, Lihong Wang*, Wei Jiang*. Identification of transcriptionfactor-miRNA-lncRNA feed-forward loops in breast cancer subtypes.Computational Biology and Chemistry 2018.11.008.

3、Shunheng Zhou†, Lihong Wang†,Qian Yang, Haizhou Liu, Qianqian Meng, Leiming Jiang, Shuyuan Wang, Wei Jiang*. Systematicalanalysis of lncRNA-mRNA competing endogenous RNA network in breast cancersubtypes. Breast Cancer Research and Treatment 2018 Jun;169(2):267-275.

4、TianLuan, Ximei Zhang, Shuyuan Wang, Jing Lin, Weiwei An, Weiguang Yuan, HuilongCai, Qingyuan Zhang*, Lihong Wang*. Long non-coding RNA MIAT promotes breast cancerprogression and functions as ceRNA to regulate DUSP7 expression by spongingmiR-155. Oncotarget. 2017 Jul 12;8(44):76153-76164.

5、Jing Lin, Wei Liu, Tian Luan,Lili Yuan, Wei Jiang, Huilong Cai, Weiguang Yuan, Yuwen Wang, Qingyuan Zhang*, Lihong Wang*. High expression of PU.1 is correlation with Her-2 and shortersurvival in breast cancer patients. Oncology Letters. 2017 14: 8220-8226.

6、Weisha Liu, Shuyuan Wang,Shunheng Zhou, Feng Yang, Wei Jiang, Qingyuan Zhang*, LihongWang*. A systems biologyapproach to identify microRNAs contributing to cisplatin resistance in humanovarian cancer cells. Mol Biosyst. 2017 Oct24;13(11):2268-2276.

7、EnyuDai, Feng Yang,Jing Wang,Xu Zhou, Qian Song, Weiwei An, Lihong Wang*, Wei Jiang*. ncDR: a comprehensive resource of non-coding RNAs involved in drug resistance. Bioinformatics. 2017 Dec15;33(24):4010-4011.

8、Liu Xinyi, Feng Dongfei, Liu Dianming, Wang Shuyuan, Yu Xuexin, DaiEenyu, Wang Jing, Wang Lihong*,Jiang Wei*. Dissecting the Origin of Breast Cancer Subtype Stem Cell and thePotential Mechanism of Malignant Transformation. PLoS One. 2016 Oct21;11(10):e0165001.

9、Ximei Zhang†, Lihong Wang†, Dongju Su, Dan Zhu, Qiuming Li, Meihua Chi. MicroRNA-29b promotesthe adipogenic differentitation of human adipose tisse-derived stromal cells.Obesity 2016; 24(5):1097-105.

10、Yan Zhang, DianmingLiu, Lihong Wang, Shuyuan Wang, Xuexin Yu, Enyu Dai, Xinyi Liu, Sanshun Luo*, Wei Jiang*. Integrated systems approachidentifies risk regulatory pathways and key regulators in coronary arterydisease.