研究方向

1、非编码RNA

2、前列腺癌发病机制研究


荣誉奖励

江苏省十三五“科教强卫工程”医学重点人才

“六大人才高峰”高层次人才

许斌(3/3,腹腔镜手术治疗原发性上尿路畸形,江苏省医学新技术引进奖,一等奖2017(陈明、陈恕求、许斌

许斌(4/4,非编码miRNAs调控网络在激素非依赖前列腺癌中的作用及机制研究,江苏医学科技奖,三等奖,2016(陈明,朱伟东,陈恕求,许斌

许斌(2/3,应用TP53通路基因变异预测中国汉族人群前列腺癌发生发展与预后,江苏省卫生厅新技术引进,二等奖,2014,(陈明,许斌,陈恕求)

许斌(2/3,应用miR-146a基因遗传变异早期诊断前列腺癌,江苏省卫生厅新技术引进,二等奖,2013,(陈明,许斌,陈恕求)

许斌(3/5基因功能区遗传变异在前列腺癌发生进展中的机制研究,南京市科技进步二等奖,2012,(冯宁翰、华立新、许斌、王巍、仝娜)

许斌(6/7)前列腺癌的基础与临床研究,江苏省科技进步三等奖,2010,(华立新、冯宁翰、王增军、王巍、张炜、许斌、吴宏飞)

学术成果

主持项目:

国家自然科学基金委员会,面上项目,81872089LncRNACCAT1通过结合AR共激活因子p68参与前列腺癌细胞激素非依赖转化及其机制研究,2019.1-2022.1255万元,在研,主持

国家自然科学基金委员会,面上项目,81672551,长链非编码基因MEG3在人前列腺基底细胞转分化及前列腺癌发生发展中的作用及机制研究,2017.1-2020.1257万元,结题,主持

国家自然科学基金委员会,青年基金,81202034NF-kBYY1miR-146a在去势抵抗性前列腺癌中相互调控的分子机制,2013.1-2015.1224万,结题,主持

“六大人才高峰”高层次人才WSW-034HOTAIR/EZH2/miR-193a环路调控去势抵抗前列腺癌上皮间质转化,2019.1-2022.12,4万元,在研,主持

学会任职

中华医学会泌尿外科学分会基础研究学组委员

中华医学会泌尿外科学分会肿瘤学组青年委员

江苏省医学会南京市泌尿外科分会青年委员

江苏省医学会南京市男科学分会青年委员


发表文章:

lMao W, Wang K, Zhang H, Lu H, SunS, Tian C, Wu Z, Wu J, Xu B, Xu H, Peng B, Chen M. Sarcopenia asa poor prognostic indicator for renal cell carcinoma patients undergoingnephrectomy in China: A multicenter study. Clin Transl Med. 2021Jan;11(1):e270.

lBin X, Yong S, Kong QF, Zhao S, ZhangGY, Wu JP, Chen SQ, Zhu WD, Pan KH, Du ML, Chen M. Diagnostic Performance ofPET/CT Using 18F-FACBC in Prostate Cancer: A Meta-Analysis. Front Oncol. 2020Jan 10;9:1438.

lGuan H, Peng R, Fang F, Mao L,Chen Z, Yang S, Dai C, Wu H, Wang C, Feng N, Xu B, Chen M.Tumor-associated macrophages promote prostate cancer progression viaexosome-mediated miR-95 transfer. J Cell Physiol. 2020 Dec;235(12):9729-9742.

lShi N, Zu F, Shan Y, Chen S, XuB, Du M, Chen M. The value of renal score in both determining surgicalstrategies and predicting complications for renal cell carcinoma: A systematicreview and meta-analysis. Cancer Med. 2020 Jun;9(11):3944-3953.

lPan KH, Jian L, Chen WJ, NikzadAA, Kong FQ, Bin X, Wang YL, Chen M. Diagnostic Performance ofContrast-Enhanced Ultrasound in Renal Cancer: A Meta-Analysis. Front Oncol.2020 Nov 18;10:586949.

lWu Y, Jing J, Wang J, Xu B,Du M, Chen M. Robotic-Assisted Sentinel Lymph Node Mapping With IndocyanineGreen in Pelvic Malignancies: A Systematic Review and Meta-Analysis. FrontOncol. 2019 Jul 2;9:585.

lGuan H, You Z, Wang C, Fang F,Peng R, Mao L, Xu BZhang M, Wang R, Wu Y, Jing J,Chen S, Zhang G, Xu B, Liu C, Chen M. Micro-Ultrasound Imagingfor Accuracy of Diagnosis in Clinically Significant Prostate Cancer: A Meta-Analysis. Front Oncol. 2019 Dec 10;9:1368.

lYou Z, Liu C, Wang C, Ling Z, WangY, Wang Y, Zhang M, Chen S, Xu B, Guan H, Chen M. LncRNA CCAT1Promotes Prostate Cancer Cell Proliferation by Interacting with DDX5 andMIR-28-5P. Mol Cancer Ther. 2019 Dec;18(12):2469-2479.

lLing Z, You Z, Hu L, Zhang L, WangY, Zhang M, Zhang G, Chen S, Xu B, Chen M. Effects of four singlenucleotide polymorphisms of EZH2 on cancer risk: a systematic review andmeta-analysis. Onco Targets Ther. 2018 Feb 16;11:851-865.

lLing Z, Guan H, You Z, Wang C, HuL, Zhang L, Wang Y, Chen S, Xu B, Chen M. Aloperine executesantitumor effects through the induction of apoptosis and cell cycle arrest inprostate cancer in vitro and in vivo. Onco Targets Ther. 2018 May11;11:2735-2743.

lHuang Y, Tao T, Liu C, Guan H,Zhang G, Ling Z, Zhang L, Lu K, Chen S, Xu B, Chen M.Upregulation of miR-146a by YY1 depletion correlates with delayed progressionof prostate cancer. Int J Oncol. 2017 Feb;50(2):421-431.

lLing Z, Wang X, Tao T, Zhang L,Guan H, You Z, Lu K, Zhang G, Chen S, Wu J, Qian J, Liu H, Xu B,Chen M. Involvementof aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression ofprostate cancer. J Exp Clin Cancer Res. 2017 Nov 15;36(1):159.

·Xu B, Huang Y, Niu X, Tao T, Jiang L,Tong N, Chen S, Liu N, Zhu W, Chen M. Hsa-miR-146a-5p modulatesandrogen-independent prostate cancer cells apoptosis by targeting ROCK1. Prostate. 2015 Dec;75(16):1896-903.

·LuK, Liu C, Tao T, Zhang X, Zhang L, Sun C, Wang Y, Chen S, Xu B*, Chen M*. MicroRNA-19a regulates proliferation andapoptosis of castration-resistant prostate cancer cells by targeting BTG1. FEBS Lett. 2015 Jun 4;589(13):1485-90.