1. Pathogenesisof  chronic  kidney disease-mineral and bone disorder（CKD-MBD）

2. Pathogenesis of  Diabetic Nephropathy(DN)

Associate chief physician, Ph.D of southeast university, Ph.D supervisor. Commissioner of Chinese Medical Doctor Association integratedmedical nephrology branch andJiangsu medical association kidney disease branch.Evaluation expert of NSFC(Natural Science Foundation of China) and so on.

Has won the first prize of natural science award of ministry of education,the second prize of Jiangsu science and technology progress award and the first prize of Jiangsu provincial health department new medical technology introduction award. Presided over 3Natural Science Foundation of China projects, and concluded 1 natural science foundation project of Jiangsu province.

The main research content at present is the pathogenesis of CKD-MBD and diabetic nephropathy.More than 40 SCI papers have already been published, of which 16 have been published as the first author, and the influence factor is over 60 points.

Published representative works in the past five years:

1. Ni LH, Tang RN(Joint first authors), Lv LL, Wu M, Wang B, Wang FM, Ni HF, Song KY, Wang LT, Meng-Zuo, Chen Q, Liu BC.A rat model of SHPT with bone abnormalities in CKD induced by adenine and a high phosphorus diet.Biochem Biophys Res Commun. 2018;498(3):654-659

2.Tang RN，Wu P，An L，NADPH oxidase p22phox C242T polymorphism is associated with macroalbuminuria in diabetic patients: A meta-analysis，Journal of Diabetes and Its Complications，2017.3.10，31(7)：1207-1211

3.Zhu DD, Tang RN(Joint first authors), Lv LL, Wen Y, Liu H, Zhang XL, Ma KL, Liu BC.Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells. Cardiovasc Diabetol. 2016;15:42.

4.Wu PP, Tang RN(Joint first authors), An L. A meta-analysis of MTRR A66G polymorphism and colorectal cancer susceptibility. J BUON. 2015; 20(3):918-922.5.Wu M, Tang RN (Joint first authors), Liu H, Pan MM, Lv LL, Zhang JD, Crowley SD, Liu BC. Cinacalcet ameliorates cardiac fibrosis in uremic hearts through suppression of endothelial-to-mesenchymal transition. Int J Cardiol, 2014;171(3):e65-69.

6.Wu M. Tang RN (Joint first authors), Liu H. Ma KL. Lv LL. Liu BC.  Nuclear translocationof β-Catenin mediates the parathyroid hormone-induced endothelial-to-mesenchymal transition in human renal glomerular endothelial cells. J Cell Biochem, 2014;115(10):1692-1701.

7.Tang RN, Lv LL, Zhang JD, Dai HY, Li Q, Zheng M, Ni J, Ma KL, Liu BC. Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats. Int J Cardiol, 2013; 162(2): 92-99.

8.Wu M,Tang RN,Liu H,Xu M,Pan MM,Liu BC.Cinacalcet attenuates the renal endothelial-to-mesenchymal transition in ratswith adenine-induced renal failure. Am J Physiol Renal Physiol, 2014;306(1):F138-146.

9.Jiang H, Tang RN(Joint first authors), Wang J.Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials.Eur J Clin Microbiol Infect Dis. 2013;32(9):1121-1128.

10.Liu BC, Tang RN, Liu ZH1. Han YC, Tu Y, Liu H, Pan MM, Tang RN, Liu BC.  Hospital-acquired acute kidney injury: an analysis of baseline estimated glomerular filtration rate and in-hospital mortality.J Nephrol. 2015 [Epub ahead of print]

12. Ding LH, Liu D, Xu M, Wu M, Liu H, Tang RN, Ma KL, Chen PS, Liu BC.TLR2-MyD88-NF-κB pathway is involved in tubulointerstitial inflammation caused by proteinuria.Int J Biochem Cell Biol. 2015;69:114-120.

13.Liu D, Wen Y, Tang TT, Lv LL, Tang RN, Liu H, Ma KL, Crowley SD, Liu BC.Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.J Biol Chem. 2015;290(29):18018-18028.

14.Wang J, Wen Y, Lv LL, Liu H, Tang RN, Ma KL, Liu BC.Involvement of endoplasmic reticulum stress in angiotensin II-induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro.Acta Pharmacol Sin. 2015;36(7):821-830.

15.Liu J, Ma KL, Zhang Y, Wu Y, Hu ZB, Lv LL, Tang RN, Liu H, Ruan XZ, Liu BC. Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease.Int J Biochem Cell Biol. 2015;61:8-619.

16.Xu M, Liu D, Ding LH, Ma KL, Wu M, Lv LL, Wen Y, Liu H, Tang RN, Liu BC.FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway.Acta Pharmacol Sin. 2014;35(12):1537-1545.

17.Ding LH, Liu D, Xu M, Liu H, Wu M, Tang RN, Lv LL, Ma KL, Liu BC.Enalapril inhibits tubulointerstitial inflammation and NLRP3 inflammasome expression in BSA-overload nephropathy of rats.Acta Pharmacol Sin. 2014;35(10):1293-1301.

18.Chen JF, Liu H, Ni HF, Lv LL, Zhang MH, Zhang AH, Tang RN, Chen PS, Liu BC.Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats.PLoS One. 2013;8(12):e83593.

19. Lv LL, Cao Y, Liu D, Xu M, Liu H, Tang RN, Ma KL, Liu BC.Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery.Int J Biol Sci. 2013;9(10):1021-31.

20.Lv LL, Cao YH, Pan MM, Liu H, Tang RN, Ma KL, Chen PS, Liu BC.CD2AP mRNA in urinary exosome as biomarker of kidney disease.Clin Chim Acta. 2014;428:26-31.

21.Ni HF, Chen JF, Zhang MH, Pan MM, Zhang JD, Liu H, Tang RN, Ma KL, Liu BC. FTY720 attenuates tubulointerstitial inflammation and fibrosis in subtotally nephrectomized rats.Ren Fail. 2013;35(7):996-1004.