The long-term goal of our research is to understand the mechanism ofrenal inflammation and fibrosis, and management of dialysis relatedcomplications. The current focus is the role of extracellular vesicle in kidneyinjury and its potential as therapeutic vectors, the injury and repair oftubular epithelial after injury, and the mechanism of cardiovascular disease indialysis patients.

1.2017Chief Professor Southeast University

2.2016Jiangsu Outstanding Medical Achievement Award

3.2015Expert of State Council Special Allowance

4.2017The outstanding young experts of the TheNational Health Commission of People’sRepublic of China

5.2018Science and Technology Progress Awards(First-Class), Zhe Jiang Province

6.2016National Science and Technology Progress Awards( Second-class)

7.2015Reward of Science and Technology(Second-class) ,Jiang Su Province

8.2015Medical Science and Technology Award of ChineseMedical Association (FirstClass)

9.2013Natural Science Award of The Ministryof Education (First-Class)

10.2008 Science and Technology Award of The Ministryof Education (First-Class)

11.2019 Science and TechnologyAward of Jiangsu Province (First-Class)

Grants:

1.The National Key Research and Development Program ofChina,(2018YFC1314000), RMB 12220,000, 2018.9-2020.12

2.Key International Cooperation Projects, NaturalScienceFoundation of China (81720108007), RMB 2480,000,2018.01—2022.12

3.Key Medical Discipline of Jiangsu Province (Jiangsu ProvinceScience and Technology Powerful Health Project),RMB2500,000, 2016.01-2021.11

4..Key program, Natural Science Foundation of China(82030024), RMB2970,000, 2021.01-2025.12

Selected publications:

1.Tang, Tao-Tao;Wang, Bin; Li, Zuo-Lin; Wen, Yi; Feng, Song-Tao; Wu, Min; Liu, Dan; Cao,Jing-Yuan; Yin, Qing; Yin, Di; Fu, Yu-Qi; Gao, Yue-Ming; Ding, Zhao-Ying; Qian,Jing-Yi; Wu, Qiu-Li; Lv, Lin-Li; Liu,Bi-Cheng. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platformfor RNAi to Treat AKI.J Am Soc Nephrol,2021 Jun 14:ASN.2020111561. doi: 10.1681/( IF=10.121, Q1 )

2.Cao JY, Wang B,Tang TT, Wen Y, Li ZL, Feng ST, Wu M, Liu D, Yin D, Ma KL, Tang RN, Wu QL, LanHY, Lv LL, Liu BC. ExosomalmiR-125b-5p deriving from mesenchymal stem cells promotes tubular repair bysuppression of p53 in ischemic acute kidney injury. Theranostics. 2021 Mar11;11(11):5248-5266. doi: 10.7150/thno.54550. ( IF=11.556,Q1 )

3.Tao-Tao Tang1*, Bin Wang1*, Min Wu1, Zuo-Lin Li1, Ye Feng1, Jing-YuanCao1, Di Yin1, Hong Liu1, Ri-Ning Tang1, Steven D. Crowley2, Lin-Li Lv1†,Bi-Cheng Liu1†Extracellular vesicle–encapsulated IL-10 as novelnanotherapeutics against ischemic AKI.Sci. Adv.2020; 6 :eaaz0748 12 August 2020( IF=14.136, Q1 )

4.Tang TT, Lv LL, Wang B, Cao JY, Feng Y,Li ZL, Wu M , Wang FM ,Wen Y, Zhou LT, Ni HF, Chen PS, Gu N, Crowley SD, Liu BC. Employing Macrophage-DerivedMicrovesicle for Kidney Targeted Delivery of Dexamethasone: An EfficientTherapeutic Strategy against Renal Inflammation and Fibrosis. Theranostics. 2019; 9(16): 4740-4755.doi: 10.7150/thno.33520. ( IF=11.556,Q1)

5.Lv LL, Feng Y, Wu M, Wang B, Li ZL, ZhongX, Wu WJ, Chen J, Ni HF, Tang TT, Tang RN, Lan HY, Liu BC. Exosomal miRNA-19b-3p of tubular epithelial cells promotesM1 macrophage activation in kidney injury. Cell Death Differ.2020 Jan;27(1):210-226.( IF=15.828, Q1)

6.Chen N, Hao C, Liu BC, Lin H,Wang C, Xing C, Liang X, Jiang G, Liu Z, Li X, Zuo L, Luo L, Wang J, Zhao MH,Liu Z, Cai GY, Hao L, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP. Roxadustat Treatmentfor Anemia in Patients Undergoing Long-Term Dialysis. N Engl J Med.2019 Sep 12381(11), 1011-1022. ( IF=91.245, Q1)

7.Wen Y, Lu X, Ren J, PrivratskyJR, Yang B, RudemillerNP, Zhang J, Griffiths R, , Crowley SD. KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis. J Am Soc Nephrol.2019 Oct;30(10):1925-1938. (IF=10.121, Q1 )

8.Li ZL, Lv LL, Tang TT,Wang B, Feng Y, Zhou LT, Cao JY, Tang RN, Wu M, Liu H, Crowley SD, Liu BC. HIF-1α inducing exosomal microRNA-23aexpression mediates the cross-talk between tubular epithelial cells andmacrophages in tubulointerstitial inflammation.Kidney Int.2019 Feb;95(2):388-404.( IF=10.612, Q1 )

9.Zhang Y, Ma KL, Gong YX, Wang GH, Hu ZB, Liu L, Lu J, Chen PP, Lu CC, RuanXZ, Liu BC. Platelet Microparticles MediateGlomerular Endothelial Injury in Early Diabetic Nephropathy. J Am Soc Nephrol. 2018 Nov;29(11):2671-2695.doi: 10.1681/ASN.2018040368. Epub 2018 Oct 19.

10.Lv LL, Feng Y, Wen Y, Wu WJ, Ni HF, LiZL, Zhou LT, Wang B, Zhang JD, Crowley SD, and Liu BC. Exosomal CCL2from Tubular Epithelial Cells Is Critical for Albumin-InducedTubulointerstitial Inflammation. J Am Soc Nephrol. 2018 Mar;29(3):919-935. doi: 10.1681/ASN.2017050523.Epub 2018 Jan 2. ( IF=10.121, Q1)

11.Lv LL, Tang PMK, Li CJ, You YK, Li JH,Huang XR, Ni J, Feng M, Liu BC andLan HY. The pattern recognition receptor, Mincle, is essential for maintainingthe M1 macrophage phenotype in acute renal inflammation. Kidney Int. 2017;91(3):587-602.10.1016 /j.kint.2016.10.020 ( IF=10.612,Q1 )

12.Zhang L, Wang F, Wang L, Wang W, Liu BC, Liu J, Chen M, He Q, Liao Y, Yu X, Chen N, Zhang JE, Hu Z, Liu F, Hong D, Ma L, Liu H, Zhou X, Chen J, Pan L, Chen W, Wang W, Li X, Wang H. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet. 2012 Mar 3;379(9818):815-22. ( IF=79.321, Q1)