学术成果:
1. 应用TP53通路基因变异预测中国汉族人群前列腺癌发生发展与预后(江苏省卫生与计划委员医学新技术引进奖二等奖,2014年)
2.应用miR-146a基因遗传变异早期诊断前列腺癌(江苏省卫生厅医学新技术引进奖二等奖,2013年)
3. 肝肾联合移植的临床和基础研究(江苏省政府科技进步奖二等奖,2004年)
4. 肝肾联合移植的临床和基础研究(南京市政府科技进步奖二等奖,2004年)
5. 谷胱甘肽转移酶Pi在膀胱癌移行细胞癌中的表达(南京市卫生局医学进步奖二等奖,1998年)
科研课题:
1.国家自然科学基金面上项目:低睾酮/肥胖/胰岛素抵抗生物轴在前列腺癌恶性进展中的作用及其分子机制的研究,2016.01~2019.12,(项目负责人)
2.国家自然科学基金面上项目(81370849):雌激素/雌激素受体-RUNX1-miR-29家族-OX40、ICOS调控通路在记忆T细胞介导的移植免疫中的作用及机制研究,2014.01~2017.12,(项目负责人)
3.国家自然科学基金面上项目(81070592):记忆T细胞在移植耐受中的作用机制的研究,2011.01~2013.12,(项目负责人)
4.教育部科研项目(20120092120071):hsa-miR-135a通过转录后调控抑制激素非依赖前列腺癌发生发展的机制研究,2013.1-2015.12,(第二名)
5.江苏省科技厅临床医学科技专项:构建雄激素合成代谢通路基因SNPs芯片评估前列腺癌发病风险和预后,2013.12-2016.12,(项目负责人)
6.江苏省自然科学基金项目(BK2012336):NF-kB-YY1-miR-146a调控环路在去势抵抗性前列腺癌中作用及其机制研究,2012.7-2015.6,(第二名)
7.江苏省自然科学基金面上项目(BK2009275):共刺激分子OX40通过调节T细胞抑制记忆T细胞诱导免疫耐受机制的研究,2009.10~2012.10,(项目负责人)
8.南京市科技局项目(201201053):miR-135a对激素非依赖前列腺癌发生发展的作用及机制研究,2012.6-2014.6(第二名)
9.南京市医学重点科技发展项目:125碘粒籽永久性植入组织间治疗前列腺癌(项目负责人)
10.南京市卫生局:新型共刺激分子(OX40)在记忆T细胞介导的胰岛移植免疫排斥及耐受机制的研究(项目负责人)
论文
1.CHUNHUI LIU*, LEI ZHANG*, YEQING HUANG*,KAI LU, TAO TAO, SHUQIU CHEN,XIAOWEN ZHANG, HAN GUAN, MING CHEN and BIN XU.MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancerproliferation and enhancing docetaxel sensitivity. MOLECULAR MEDICINE REPORTS.2015,12:7389-7395. (通讯作者)
2.Chen M, Liu N, Chen S, Liu J, Sha G, Zhu W, Xu B.Laparoscopic inferior mesenteric-gonadal vein end-to-side by pass: a newattempt for nutcracker syndrome treatment. Ann Vasc Surg. 2015 Jun 11
3.Chen S, Xu B, Liu N, Jiang H, Zhang X, Yang Y, Liu J, Sha G, Zhu W, Chen M.Improvedeffectiveness and safety of flexible ureteroscopy for renal calculi (<2 cm):A retrospective study. Can Urol Assoc J. 2015May-Jun;9(5-6):E273-7. (通讯作者)
4.Liu CH, Tao T, Jiang L, Xu B, Zhang L, Lu K, Zhang XW, Chen SQ, Liu DC, Chen M.DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis. Genet Mol Res. 2015 Apr17;14(2):3640-9. (通讯作者)
5.Liu C, Lu K, Tao T, Zhang L, Zhang X, Jiang L, Huang Y, Guan H1, Chen M, Xu B.Endothelialnitric oxide synthase polymorphisms and erectile dysfunction: a meta-analysis. J Sex Med. 2015Jun;12(6):1319-28. (通讯作者)
6.Lu K, Liu C, Tao T, Zhang X, Zhang L, Sun C, Wang Y, Chen S, Xu B, Chen M.MicroRNA-19a regulates proliferation and apoptosis of castration-resistantprostate cancer cells by targeting BTG1. FEBS Lett. 2015Jun 4;589(13):1485-90. (通讯作者)
7.Jin J, Chen L, Zhu Z, Wang Y, Chen M,Wang Q, Peng X.Magnetic resonance evaluations of correlation of iron overload and osteoporosisin ovariectomized rats. Zhonghua Yi Xue ZaZhi. 2015 Feb 17;95(7):537-40. (通讯作者)
8.Chen M, Zhou ZY, Chen JG, Tong N, Chen SQ, Yang Y, Zhang XW, Jiang H, Liu N, Liu J, Sha GZ, Zhu WD, Hua LX, Wang ZJ, Xu B.Effect of miR-146a polymorphism on biochemical recurrence risk after radicalprostatectomy in southern Chinese population. Genet Mol Res. 2014 Dec 18;13(4):10615-21.
9.Tao T, Li GF, Dong QS, Liu D, Liu DC,Liu CH Han DF,Huang YQ, Chen SQ, Xu B, ChenM. Loss of SNAIL inhibits cellular growth and metabolism through themiR-128-mediated RPS6KB1/HIF-1α/PKM2 signaling pathway in prostate cancercells. Tumour Biol. 2014 Sep;35(9):8543-50.
10.Wang Y, Qu H, Zhang L, Chen S, Xu B, Lu K, Liu C, Tao T, Yang Y, Chen M. Safety and PostoperativeOutcomes of Regional versus Global Ischemia for Partial Nephrectomy: ASystematic Review and Meta-Analysis. UrolInt. 2014;94(4):428-35. (通讯作者)
11.TaoT, Liu DC, Liu CH, Xu B,Chen SQ, Yin Y, Ang L, Huang YQ, Zhang XW, ChenM. Autoregulatory feedback loop of EZH2/miR-200c/E2F3 as a drivingforce for prostate cancer development. Biochimica etBiophysica Acta-Gene Regulatory Mechanisms.2014SEP;1839(9):858-865. (通讯作者)
12.TaoT, Chen SQ, Xu B, Liu CH, Wang YD, Huang YQ, Chen M. Association between hsa-miR-34b/c rs4938723 T > Cpromoter polymorphism and cancer risk: a meta-analysis based on 6,036 cases and6,204 controls. Chinese Journal of Cancer Research.2014JUN;26(3):315-322,2014. (通讯作者)
13.ChenSQ, Liu DC,Wu JP, Xu B,Lu K,Zhu WD,ChenM. Effect of inhibiting the signal of mammalian target of rapamycin onmemory T cells. Transplan Procced, 2014 JUN;46(5):1642-1648.(通讯作者)
14.Liu D, Tao T, Xu B, Chen S,Liu C, Zhang L, Lu K, Huang Y, Jiang L, Zhang X, Huang X, Zhang L, Han C, ChenM. MiR-361-5p acts as a tumour suppressor in prostate cancer bytargeting signal transducer and activator of transcription-6 (STAT6). BiochemBiophys Res Commun. 2014 Feb 28;445(1):151-6.(通讯作者)
15.LiuDC,Xu B,Chen SQ,YanG Y,Zhang XW,Liu J,Lu K,Zhang L,Liu CH,Zhao YM.Ming Chen. Longnon-coding RNAs and prostate cancer.J Nanosce Nanotechno, 2013 MAY;13(5): 3186-3194. (通讯作者)
16.ZhangL,Xu B,Chen SQ,Lu K,Liu CH,Wang YD,Zhao YM,Zhang XW,Liu DC, Chen M. The complex roles ofmicroRNAs in the metastasis of renal cell carcinoma. J Nanosce Nanotechno,2013MAY; 13(5):3195-3203. (通讯作者)
17.Chen S, Xu B, Liu J, Ren Q,Hu X, Yang Y, Zhang XW, Chen M. Retroperitoneal laparoscopicreconstruction for retrocaval ureter: experience and literature review. JEndourol. 2012 Sep;26(9):1147-52. (通讯作者)
18.Xu B, Wang N, Wang XH, TongN, Shao N, Tao J, Li PC, Niu XB, Feng NH, Zhang LH, Hua LX, Wang ZJ,ChenM. MiR-146asuppresses tumor growth and progression by targeting EGFR pathway and in ap-ERK dependent manner in castration-resistant prostate cancer. Prostate. 2012Aug 1;72(11):1171-8 . (通讯作者)
19.Xu B, Tong N, Chen S, YangY, Zhang X, Liu J, Hu X, Sha G, Chen M. Contribution of HOGG1Ser326Cys polymorphism to the development of prostate cancer in smokers:meta-analysis of 2779 cases and 3484 controls. Plos One. 2012;7(1):e30309.(通讯作者)
20.WangAX, Xu B, Tong N, Chen SQ, Yang Y, Zhang XW, Jiang H, Liu N, Liu J, Hu XN, ShaGZ, Chen M. Meta-analysisconfirms that a common G/C variant in the pre-miR-146a gene contributes tocancer susceptibility and that ethnicity, gender and smoking status are riskfactors. Genet Mol Res.2012,AUGUST;11(3):3051-3062. (通讯作者)
21.Ren Q, Xu B, Chen SQ, YangY, Wang CY, Wang YD, Wang XH, Hua LX, Chen M. A common geneticvariant of 5p15.33 is associated with risk for prostate cancer in the Chinesepopulation. Genet Mol Res. 2012,MAY;11(2):1349-56.(通讯作者)
22.Xu B, Tong N, Chen SQ, HuaLX, Wang ZJ, Zhang ZD,Chen M. FGFR4 Gly388Arg polymorphismcontributes to prostate cancer development and progression: A meta-analysis of2618 cases and 2305 controls. BMC Cancer. 2011,FEB;11(84).(通讯作者)
23.ChenM,Xiao X, Demirci G, Li X. OX40 controls islet allograft tolerance in CD154deficient mice by regulating FOXP3+ Tregs. Transplantation. 2008,85(11): 1659-1662.
24.Chen M, Li XC. Approaches and challenges in targeting memory T cells intransplant tolerance. Arch Immunol Ther Exp (Warsz). 2007SEP,55(5):309-314,.
25.Chen M, Kroemer A,Li XC.Induction of stable islet allograft tolerance by targetingOX40 costimulatory pathway.American Jounarl of Transplantation. 2007MAY,7:510-511.
26.陈明,王润,柳靖.阴茎假体植入术的临床应用与手术技巧[J].现代泌尿外科杂志,2015,20(1):1-3.
27.凌志新,陈明.非编码RNA在前列腺癌诊疗中应用新进展[J].东南大学学报:医学版,2015,34(2):299-303.(通讯作者)
28.黄烨清,陈明.前列腺癌动物模型的研究进展[J].东南大学学报:医学版,2014,33(2):206-210.(通讯作者)
29.单勇,卢凯,张磊,刘春辉,许斌,陈恕求,陈明.PKRP与PVP治疗高龄高危前列腺增生的疗效比较[J].现代医学,2014,42(12):1481-1483.(通讯作者)
30.卢凯,许斌,陈恕求,张磊,刘春辉,赵宇明,陈明.miR-19a对于去势抵抗性前列腺癌细胞的增殖及凋亡的调控[J].现代医学,2014,41(9):613-616.(通讯作者)
31.刘春辉,许斌,张磊,卢凯,陈恕求,陈明.BTG1在HK-2和786-O细胞株中的表达及其对细胞周期和细胞凋亡的影响[J].东南大学学报:医学版,2013,32(5):533-538.(通讯作者)
32.刘宁,陈明,陈恕求,许斌,茅晓云.前列腺增生患者尿流动力学检查前预防性应用抗生素的研究[J].中华男科学杂志,2013,19(11):996-998.
33.陈恕求,许斌,任全,王奕铎,王旭辉,李先昌,陈明.靶向OX40/OX40L通路对CD4+CD25+调节性T细胞诱导移植耐受的影响[J].中华实验外科杂志,2012,29(9):1791- 1793. (通讯作者)
34.陈恕求,陈明,许斌,任全,王奕铎,王旭辉,李先昌.阻断OX40和CD40协同共刺激信号延长小鼠胰岛移植物存活时间[J].中华器官移植杂志,2012,33(3):174-177.(通讯作者)
35.姜华,陈明,柳靖,胡向农,张晓文,杨瑜,陈恕求,许斌.B超引导下经皮肾镜气压弹道联合超声碎石术治疗复杂肾结石,江苏医药,2012,38(17):2028-2030.(通讯作者)
36.陈恕求,陈明,张晓文,柳靖,胡向农,杨瑜,高明.长期血透患者获得性囊性肾病合并肾癌8例报告并文献复习[J].临床泌尿外科杂志,2012,27(1):33-35.(通讯作者)
37.卢凯,陈明.OX40/OX40L与T细胞[J].东南大学学报:医学版,2012,31(3):355-358.(通讯作者)
38.王旭辉,陈明.miRNA和前列腺癌发生发展的关系[J].东南大学学报:医学版,2012,31(4):512-515.(通讯作者)
39.陈明,陈恕求,柳靖,胡向农,张晓文,杨瑜.肾盂膀胱皮下输尿管旁路术治疗晚期肿瘤的输尿管梗阻.江苏医药,2011,27(23):2768-2770.
40.陈恕求,许斌,任全,王奕铎,陈明.双共刺激通路阻断诱导小鼠胰岛移植耐受,中华实验外科杂志,28:2246,2011.(通讯作者)
41.陈明,陈恕求,胡向农,张晓文,李先昌.抑制记忆性T细胞共刺激分子OX40延长小鼠胰岛移植物的存活时间.中华器官移植杂志,2011,32(5):305-308.
42.成功,陈明,张古田,孙则禹,杨斌,崔寿喜.帕雷霉素对小鼠T淋巴细胞的体外作用.江苏医药,2008,34(3):260-262.
43.陈恕求,陈明,张古田,李俊龙,彭涛,孙则禹.T淋巴细胞在小鼠神缺血再灌注损伤中的作用.中国实验动物学报,2007,15(1):21-24.