Professor Baoan Chen(MD/PhD) isa renowned hematologist and oncologist in China. He is the director of Facultyof Oncology of Southeast University, leader of Department of Hematology of theAffiliated Zhongda Hospital of Southeast University, head of MDS ResearchInstitute. He got his bachelor’s degree and master‘s degree in Nanjing RailwayMedical College, MD/PhD degree in Shanghai Medical University, and completedhis post doc. training in Department of Hematology and Oncology of ULMUniversity. He is the senior visiting scholar in MD Aderson Cancer Center, UCBerkely, University of Heidelberg and several world‘s famous universities.Professor Chen has rich experience in hematological malignancies diagnosis andtreatment. His research interests include overcoming multidrug resistance ofcancer, preventing and treating relapse of leukemia after HSCT and basic andclinical research of MDS.

Selected Research Programs:

National Key Basic Research and Development Program (973 Program):Research and Systematic Design of Sensing and Imaging Methods Based onBioinspired Molecular Recognition

(Grant NO.: 2010CB732404, period:2009-2015)

National High Technology Research and Development Program(863Program): A biomarker for the detection of low-cost system. (GrantNO.:2012AA022703, period: 2012-2016)

National Natural Science Foundation of China: Research onDesigning of transferrin nanocarriers of chemotherapy drugs and traditionalChinese medicine and mechanism of leukemia reverasal. (Grant NO.: 81170492,period: 2012-2015)

National Natural Foundation of China: Development of drug deliverysystems containing platelet targeting and research about its anti-leukemia effect.(Grant NO.: 81370673, period: 2014-2017)

Key project of Jiangsu Province: standardized treatment ofrelapsed and refractory leukemia (Grant NO: BL2014078, period: 2014-2017)

Selected Publications in Recent 5 Years:

1.CaiX, Cai X, Wang C, ChenBA*, Hua W, Shen Fet al. Antitumor efficacy of DMSA modified Fe3O4 magnetic nanoparticlescombined with arsenic trioxide and adriamycin in Raji cells. J Biomed Nanotech2014; 10(2): 251-261.

2.ChangH, Wang X, Shiu KK, Zhu Y, Wang J, Li Q, Chen BA* et al. Layer-by-layerassembly of graphene, Au andpoly(toluidine blue O) films sensor for evaluationof oxidative stress of tumorcells elicited by hydrogen peroxide. Biosensors& Bioelectronics 2013;41: 789-794.

3.ChengJ, Cheng L, ChenBA*, Xia G, Gao C, Song Het al. Effect of magnetic nanoparticles of Fe3O4 and wogonin onthereversal of multidrug resistance in K562/A02 cell line. Int J Nanomedicine2012;7: 2843-2852.

4.FangL, ChenBA,Liu S, Wang R, Hu S, Xia G, Chen BA* et al.Synergistic effect of a combination ofnanoparticulate Fe3O4 and gambogic acidon phosphatidylinositol 3-kinase/Akt/Badpathway of LOVO cells. Int JNanomedicine2012; 7: 4109-4118.

5.JiangN, Zhu X, Zhang H, Wang X, Zhou X, Gu J, Chen BA* et al. The relationshipbetween methylenetetrahydrofolatereductase polymorphism and hematologicalmalignancy. Clin Lab2014;60(5): 767-774.

6.JinN, Malcherek G, Mani J, Zurleit R, Schmitt A, Chen BA et al. Suppression ofcytomegalovirus-specific CD8(+)T cells by everolimus. Leuk Lymphoma 2014; 55(5): 1144-1150.

7.LiK, ChenBA*,Xu L, Feng J, Xia G, Cheng J et al.Reversal of multidrug resistance bycisplatin-loaded magnetic Fe3O4nanoparticles in A549/DDP lung cancer cells invitro and in vivo. Int J Nanomedicine 2013; 8: 1867-1877.

8.LiangG, Li J, Sun B, Li S, Lu L, Wang Y, Chen BA* et al. Deep sequencingreveals complex mechanisms ofmicroRNA deregulation in colorectal cancer. Int J Oncology 2014; 45(2): 603-610.

9.LuX, Zhu A, Cai X, Jia Z, Han W, Ma L, Chen BA* et al. Role of NKG2D incytokine-induced killer cellsagainst multiple myeloma cells. CancerBio Therapy 2012; 13(8): 623-629.

10.MouY, Hou Y, ChenBA*, Hua Z, Zhang Y, Xie Het al. In vivo migration of dendritic cells labeled withsyntheticsuperparamagnetic iron oxide. Int J Nanomedicine 2011; 6: 2633-2640.

11.RenY, Zhang H,Chen BA*, Cheng J, Cai X, Liu R et al. Multifunctional magnetic Fe3O4nanoparticles combined withchemotherapy and hyperthermia to overcome multidrugresistance. Int J Nanomedicine2012; 7:2261-2269.

12.SongG, Gu L, Li J, Tang Z, Liu H, Chen BA* et al. SerummicroRNAexpression profiling predict response to R-CHOP treatment in diffuselarge Bcell lymphoma patients. AnnHematol 2014.e-pub ahead of print 2014/05/27

13.WangC, Cai X, ChenBA*, He Z, Chen Z, Cen Jet al. Up-regulation of tissue inhibitor ofmetalloproteinase-2promotes SHI-1 cell invasion in nude mice. Leuk Lymphoma 2013; 54(12): 2707-2711.

14.WangC, Zhang H, Chen Y, Shi F, Chen BA*. Gambogic acid-loaded magneticFe(3)O(4)nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation andmigrationby inactivating transcription factor ETS1. Int J Nanomedicine2012; 7: 781-787.

15.Wang F, Zhang W, Guo L, Bao W,Jin N, Liu R, Chen BA* et al. Gambogic acidsuppresses hypoxia-inducedhypoxia-inducible factor-1alpha /vascular endothelialgrowth factor expressionvia inhibiting phosphatidylinositol3-kinase/Akt/mammalian target protein ofrapamycin pathway in multiple myelomacells. Cancer Sci2014.e-pub ahead of print 2014/06/04.

16.WangL, Zhang H, ChenBA*, Xia G, Wang S, Cheng Jet al. Effect of magnetic nanoparticleson apoptosis and cell cycleinduced by wogonin in Raji cells. Int J Nanomedicine2012; 7: 789-798.

17.WangX, Wang X, Gao S, Zheng Y, Tang M, ChenBA*. Asolid-state electrochemiluminescencesensing platform for detection of catecholbased on novel luminescent compositenanofibers. Talanta 2013; 107: 127-132.

18.WenJ, Jiang S, Chen Z, Zhao W, Yi Y, Yang R, Chen BA* et al. Apoptosisselectively induced in BEL-7402 cells byfolic acid-modified magneticnanoparticles combined with 100 Hz magnetic field.Int J Nanomedicine2014; 9: 2043-2050.

19.XuP,Chen BA*,Feng J, Cheng L, Xia G, Li Y et al.Polymorphisms inXPC provide prognostic information in acute myeloid leukemia. Int J Hematology 2012; 96(4): 450-460.

20.XuP, Li J, ChenBA*, Wang X, Cai X, Jiang Het al. The real-time neurotoxicityanalysis of Fe3O4 nanoparticlescombined with daunorubicin for rat brain invivo. J Biomed Nanotechnology 2012; 8(3): 417-423.

21.XuP, Li J, Shi L, Selke M, Chen BA*, Wang X. Synergetic effect offunctionalcadmium-tellurium quantum dots conjugated with gambogic acid forHepG2cell-labeling and proliferation inhibition. Int J Nanomedicine2013; 8: 3729-3736.

22.XuY, Wang Y, Li XM, Huang Q, Chen W, Liu R, Chen BA* et al. Study on therelease of fenofibrate nanosuspension invitro and its correlation with in situintestinal and in vivo absorptionkinetics in rats. Drug Dev Indus Pharmacy2014; 40(7): 972-979.

23.YangZ, ChenBA*,Pei X, Shangguan F. Multiplex analysis of tumormultidrug-resistance genesexpression with photonic suspension array. TheAnalyst 2012; 137(14): 3343-3348.

24.ZhangH, Wang C, ChenBA*, Wang X. Daunorubicin-TiO2 nanocompositesas a"smart" pH-responsive drug delivery system. Int J Nanomedicine2012; 7: 235-242.

25.ZhongY, Wu J, ChenBA*, Ma R, Cao H, Wang Zet al. Investigation and analysis of single nucleotidepolymorphismsin Janus kinase/signal transducer and activator of transcriptiongenes withleukemia. Leuk Lymphoma 2012;53(6): 1216-1221.

26. Zhang HJ, ChenBA*,Jiang H, Wang CL, Wang HP, Wang XM. A strategy for ZnOnanorod mediatedmulti-mode cancer treatment. Biomaterials. 2011; 32(7):1906-14.

27. ChenBA*, Wu WW, WangXM. Magnetic Iron Oxide Nanoparticles forTumor-targeted Therapy. Curr CancerDrug Targets 2011; 11(2):184-9.

28. Zhang HJ, Jiang H, Sun FF, Wang HP, Zhao J, Chen BA*, Wang XM.Rapid diagnosis of multidrug resistance in cancerby electrochemical sensorbased on carbon nanotubes-drug supramolecularnanocomposites. BiosensBioelectron. 2011; 26(7):3361-6.

29. Song M, Zhang RR, Dai YY, Gao F, Chi H, Lv G, Chen BA,* Wang XM. The invitro inhibitionof multidrug resistance by combined nanoparticulate titaniumdioxide and UV irradition.Biomaterials. 2006; 27(23):4230-8.

30. ChenBA*, Yin L, ChengJ, Ding JH, Gao C, Sun YY, Zhao G, Wang J, BaoW, Xia GH, Gao F, Wang XM.Effect of D,L-threo-1-phenyl-2-decanoylamino-3-morpholino-1 -propanol andtetrandrine on thereversion of multidrug resistance in K562/A02 cells.Hematology. 2011;16(1):24-30.

31. Wu WW, ChenBA*, ChengJ, Wang J, Xu WL, Liu LJ, Xia GH, Wei H, Wang XM,Yang M, Yang L, Zhang Y, XuC, Li J. Biocompatibility of Fe3O4/DNR magneticnanoparticles inthe treatmentof hematologic malignancies. Int J Nanomedicine.2010; 5:1079-84.

32. Wang J, Chen Y,Chen BA*,Ding JH, Xia GH, Gao C, Cheng J, Jin N, Zhou Y, Li XM,Tang M, Wang XM.Pharmacokinetic parameters and tissue distribution of magneticFe(3)O(4) nanoparticlesin mice. Int J Nanomedicine. 2010; 5:861-6.

33. ChenBA*, Mao P, ChengJ, Gao F, Xia GH, Xu WL, Shen HL, Ding JH, GaoC, Sun Q, Chen W, Chen N, LiuLJ, Li XM, Wang XM. Reversal of multidrugresistance by magnetic Fe3O4nanoparticle copolymerizating daunorubicin and MDR1shRNA expression vector inleukemia cells. Int J Nanomedicine. 2010; 5:437-4.

34. ChenBA*, Jin N, WangJ, Ding JH, Gao C, Cheng J, Xia GH, Gao F, ZhouY, Chen Y, Zhou G, Li XM, ZhangY, Tang M, Wang XM. The effect of magneticnanoparticles of Fe(3)O(4) on immunefunction in normal ICR mice. Int JNanomedicine. 2010; 5:593-9.

35. Zhang HJ, Jiang H, Wang XM, Chen BA*. Reversion ofmultidrugresistance in tumor by biocompatible nanomaterials. Mini Rev Med Chem.2010;10(8):737-45.

36. Zhong YJ, ChenBA*,Feng JF, Cheng L, Li Y, Qian J, Ding JH, Gao F, Xia GH,Chen N, Lu Z. Theassociations of Janus kinase-2 (JAK2) A830G polymorphism andthe treatment outcomesin patients with acute myeloid leukemia. Leuk Lymphoma.2010; 51(6):1115-20.

37. Zhu XL, Zhang HJ, Lin Y, Chen P, Min J, Wang Z, Xiao W, Chen BA*. Mechanismsof gambogicacid-induced apoptosis in non-small cell lung cancer cells inrelation to transferrinreceptors. J Chemother. 2009; 21(6):666-72.

38. Pei XP, ChenBA*, LiL, Gao F, Jiang Z. Multiplex tumor marker detection withnew chemiluminescentimmunoassay based on silica colloidal crystal beads.Analyst. 2010; 135(1):177-81.

39. ChenBA*, Liang YQ, WuWW, Cheng J, Xia GH, Gao F, Ding JH, Gao C,Shao Z, Li G, Chen W, Xu WL, SunXC, Liu LJ, Li XM, Wang XM. Synergistic effectof magnetic nanoparticles ofFe(3)O(4) with gambogic acid on apoptosis of K562leukemia cells. Int J Nanomedicine.2009; 4:251-9.

40. Cheng J, Wu WW, ChenBA*,Gao F, Xu WL, Gao C, Ding JH, Sun YY, Song HH, Bao W, SunXC, Xu C, Chen W,Chen N, Liu LJ, Xia GH, Li XM, Wang XM. Effect of magneticnanoparticles ofFe3O4 and 5-bromotetrandrine on reversal of multidrugresistance in K562/A02leukemic cells. Int J Nanomedicine. 2009; 4:209-16.

41. Pei XP, Zhao Y, Zhao X, Xu H, Chen BA*, Gu ZZ. Multiplex chemiluminescentimmunoassay based onsilica colloidal crystal beads. J N N. 2009; 9(11):6320-5.

42. Sun N, Sun XC, ChenBA*,Cheng H, Feng JF, Cheng L, Lu ZH. MRP2 and GSTP1polymorphisms and chemotherapyresponse in advanced non-small cell lung cancer.Cancer Chemoth Pharm. 2010;65(3):437-46.

43. Li Y, Deng Z, Xuan H, Zhu J, Ding B, Liu X, Chen BA*. Prolongedchronic phase in chronic myelogenous leukemiaafter homoharringtonine therapy.Chin Med J (Engl). 2009;122(12):1413-7.

44. Jiang Z, ChenBA*, XiaGH, Wu Q, Zhang Y, Hong T, Zhang W, Cheng J, Gao F, LiuLJ, Li XM, Wang XM. Thereversal effect of magnetic Fe3O4 nanoparticles loadedwith cisplatin onSKOV3/DDP ovarian carcinoma cells. Int J Nanomedicine. 2009;4:107-14.

45. ChenBA*, Cheng J, WuYN, Gao F, Xu WL, Shen HL, Ding JH, Gao C, SunQ, Sun XC, Cheng H, Li G, ChenW, Chen N, Liu LJ, Li XM, Wang XM. Reversal ofmultidrug resistance by magneticFe3O4 nanoparticle copolymerizatingdaunorubicin and 5-bromotetrandrine inxenograft nude-mice. Int J Nanomedicine.2009; 4:73-8.

46. ChenBA*, Cheng J,Shen MF, Gao F, Xu WL, Shen HL, Ding JH, Gao C,Sun Q, Sun XC, Cheng H, Li G,Chen W, Chen N, Liu LJ, Li XM, Wang XM. Magneticnanoparticle of Fe3O4 and5-bromotetrandrin interact synergistically to induceapoptosis by daunorubicin inleukemia cells. Int J Nanomedicine. 2009; 4:65-71.

47. ChenBA*, Dai YY, WangXM, Zhang R, Xu WL, Shen HL, Gao F, Sun Q,Deng X, Ding JH, Gao C, Sun Y, ChengJ, Wang J, Zhao G, Chen N. Synergisticeffect of the combination of nanoparticulateFe3O4 and Au with daunomycin onK562/A02 cells. Int J Nanomedicine. 2008;3(3):343-50.

48. ChenBA*, Sun Q, WangXM, Gao F, Dai YY, Yin Y, Ding JH, Gao C, ChengJ, Li JY, Sun XC, Chen N, XuWL, Shen HL, Liu D. Reversal in multidrugresistance by magnetic nanoparticleof Fe3O4 loaded with adriamycin andtetrandrine in K562/A02 leukemic cells. IntJ Nanomedicine. 2008; 3(2):277-86.