研究方向

噪声和耳毒性药物的内耳损伤机理,外周听觉器官损伤后听觉中枢的功能重组,听觉中枢的编码机理,耳蜗基因治疗,听力损失对学习,记忆和认知能力的影响和机理等。

荣誉奖励
学术成果

近五年发表SCI论文:

1.      WangJ, Song Q, Yu D, Yang G, Xia L, Su K, et al. Ontogenetic development ofauditory sensory organ in zebrafish (Danio rerio): changes in hearingsensitivity and related morphology. Scientific Reports. Accepted.

2.      ChenYC, Li X, Liu L, Wang J, Lu CQ, Yang M, et al. Tinnitus and hyperacusis involvehyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellarnetwork. eLife. 2015;4:e06576.

3.      ChenYC, Xia W, Feng Y, Li X, Zhang J, Feng X, et al. Altered interhemisphericfunctional coordination in chronic tinnitus patients. BioMed researchinternational. 2015;2015:345647.

4.      ChenYC, Zhang J, Li XW, Xia W, Feng X, Qian C, et al. Altered intra- andinterregional synchronization in resting-state cerebral networks associatedwith chronic tinnitus. Neural plasticity. 2015;2015:475382.

5.      JieH, Tao S, Liu L, Xia L, Charko A, Yu Z, et al. Cochlear protection againstcisplatin by viral transfection of X-linked inhibitor of apoptosis proteinacross round window membrane. Gene Ther. 2015.

6.      ZhangGY, Yang M, Liu B, Huang ZC, Chen H, Zhang PP, et al. Changes in the defaultmode networks of individuals with long-term unilateral sensorineural hearingloss. Neuroscience. 2015;285:333-42.

7.      ZhangJ, Chen YC, Feng X, Yang M, Liu B, Qian C, et al. Impairments of thalamicresting-state functional connectivity in patients with chronic tinnitus.European journal of radiology. 2015.

8.      ChenYC, Zhang J, Li XW, Xia W, Feng X, Gao B, et al. Aberrant spontaneous brainactivity in chronic tinnitus patients revealed by resting-state functional MRI.NeuroImage Clinical. 2014;6:222-8.

9.      RuanQ, Ao H, He J, Chen Z, Yu Z, Zhang R, et al. Topographic and quantitativeevaluation of gentamicin-induced damage to peripheral innervation of mousecochleae. Neurotoxicology. 2014;40:86-96.

10.    RuanQ, Zeng S, Liu A, Chen Z, Yu Z, Zhang R, et al. Overexpression of X-LinkedInhibitor of Apoptotic Protein (XIAP) reduces age-related neuronal degenerationin the mouse cochlea. Gene Ther. 2014;21(11):967-74.

11.    XiaL, Chen Z, Su K, Yin S, Wang J. Comparison of cochlear cell death caused bycisplatin, alone and in combination with furosemide. Toxicol Pathol.2014;42(2):376-85.

12.    ShiL, Liu L, He T, Guo X, Yu Z, Yin S, et al. Ribbon synapse plasticity in thecochleae of Guinea pigs after noise-induced silent damage. PLoS One.2013;8(12):e81566.

13.    YeHB, Wang J, Zhang WT, Shi HB, Yin SK. Taurine attenuates bilirubin-inducedneurotoxicity in the auditory system in neonatal guinea pigs. Int J PediatrOtorhinolaryngol. 2013;77(5):647-54.

14.    LiuL, Wang H, Shi L, Almuklass A, He T, Aiken S, et al. Silent damage of noise oncochlear afferent innervation in guinea pigs and the impact on temporalprocessing. PLoS One. 2012;7(11):e49550.

15.    Wang H,Murphy R, Taaffe D, Yin S, Xia L, Hauswirth WW, et al. Efficient cochlear genetransfection in guinea-pigs with adeno-associated viral vectors by partialdigestion of round window membrane. Gene Ther. 2012;19(3):255-63.

16.    Xia L, Yin S,Wang J. Inner ear gene transfection in neonatal mice using adeno-associatedviral vector: a comparison of two approaches. PLoS One. 2012;7(8):e43218.

17.    Ye HB, ShiHB, Wang J, Ding DL, Yu DZ, Chen ZN, et al. Bilirubin induces auditory neuropathyin neonatal guinea pigs via auditory nerve fiber damage. J Neurosci Res.2012;90(11):2201-13.

18.    Galluzzi L,Kepp O, Kroemer G. FADD: an endogenous inhibitor of RIP3-driven regulatednecrosis. Cell research. 2011;21(10):1383-5.

19.    Galluzzi L,Vanden Berghe T, Vanlangenakker N, Buettner S, Eisenberg T, Vandenabeele P, etal. Programmed necrosis from molecules to health and disease. Internationalreview of cell and molecular biology. 2011;289:1-35.

20.    Wang H, YinS, Yu Z, Huang Y, Wang J. Dynamic changes in hair cell stereocilia and cochleartransduction after noise exposure. Biochem Biophys Res Commun.2011;409(4):616-21.

21.    Wang J,Tymczyszyn N, Yu Z, Yin S, Bance M, Robertson GS. Overexpression of X-linkedinhibitor of apoptosis protein protects against noise-induced hearing loss inmice. Gene Ther. 2011;18(6):560-8.