本课题组通过药理学、细胞生物学、分子生物学等实验技术，结合细胞与动物模型，致力于在细胞和分子水平阐明调控癫痫疾病发生的作用机制，旨在为癫痫疾病的药物治疗提供理论依据，并为癫痫疾病的治疗开拓新的视角。

获奖情况：

1、“东南大学医学院首届微课竞赛二等奖”

2、“东南大学第23届青年教师授课竞赛三等奖”

3、“首届全国MBBS项目青年教师英文讲课大赛优秀奖”

4、“江苏省药理学会青年教师微课竞赛三等奖”

5、“东南大学教育基金会大连东岗奖教金”

6、“东南大学无线电系七八年级同学奖教金”

7、“东南大学医学院最受欢迎老师称号”

8、美国宾夕法尼亚大学研究成果奖 “Award for Laboratorybasedresearch track at the 22^nd annual Children’s Hospital ofPhiladelphia （CHOP）at Universityof Pennsylvania ResearchPoster Day (Philadelphia, PA, USA)

科研项目：

1、国家自然科学基金面上项目，81872846“海马犬尿氨酸代谢失衡在颞叶癫痫中的作用及其机制研究”，2019/01-2022/12，主持。

2、国家自然科学基金面上项目，81673413“miR-23a靶向调控ADAM10基因在颞叶癫痫中的作用及其机制研究”，2017/01-2018/12，主持。

3、教育部留学回国人员科研启动基金“NMDA受体通过转录因子CREB调控癫痫发生的作用及其细胞分子机制研究”2015/03-2018/6，主持。

4、江苏省自然科学基金面上项目，BK20141335、“NMDA受体通过转录因子CREB调控癫痫发生及其分子机制研究”2014/07-2017/06，主持。

5、高等学校博士学科点专项科研基金项目，“NMDA受体NR2B亚基调控癫痫发生的作用及其分子细胞机制研究”，2014/01-2016/12，主持。

教学项目：

1、“美国田纳西大学教学提升项目”，2018/08-2018/12。

2、东南大学教学改革重点项目 “留学生临床药理学课程教学评估体系的探索”，2018/01-2020/12，主持。

(1) Zhu X*, Yao Y, Yang J, Ge Q, Niu D, Liu X, Zhang C, Gan G,Zhang A, Yao H.Seizure-induced neuroinflammation contributes toectopic neurogenesis and aggressive behavior in pilocarpine-induced statusepilepticus mice. Neuropharmacology. 2020,170:108044.

(2) Zhu X*, Zhang A,Dong J, Yao Y, Zhu M, Xu K, Al Hamda MH. MicroRNA-23acontributes to hippocampal neuronal injuries and spatial memory impairment inan experimental model of temporal lobe epilepsy. Brain Res Bull. 2019, 152: 175-183.

(3) Zhu X*, Yao Y, Liu Y, Zhou R, Zhang W, Hu Q, Liu H, Al Hamda MH1, Zhang A. Regulationof ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-InducedStatus Epilepticus Mice. Front Cell Neurosci. 2019, 30; 13:180.

(4) ZhuX*, Yao Y, Li X, Dong J, Zhang A. Alterationof GABAergic signaling is associated with anxiety-like behavior in temporallobe epilepsy mice. Prog Neuropsychopharmacol Biol Psychiatry. 2019; 93:141-148.

(5) Zhu X*, Li X, Zhu M, Xu K, Yang L, Han B, Huang R, Zhang A, Yao H.,Metalloprotease Adam10 suppresses epilepsy through repression of hippocampalneuroinflammation. J Neuroinflammation. 2018;15 (1):221. (7) Zhu X*, Dong J, Han B, Huang R, ZhangA, Xia Z, Chang H, Chao J, Yao H., Neuronalnitric oxide synthase contributes to PTZ kindling-induced cognitive impairmentand depressive-like behavior. Front Behav Neurosci.2017;11:203.

(8) Zhu X*, Dong J, Xia Z, Zhang A, Chao J, Yao H., Repeated restraint stress increases seizuresusceptibility by activation hippocampal endoplasmic reticulum stress. NeurochemInt.2017;110:25-37.

(9) 杨展能, 姜靓婧，顾仕红，陈磊，黎虹薇，朱新建*. NMDA受体在匹罗卡品癫痫小鼠海马星形胶质细胞活化中的作用. 东南大学学报（医学版）. 2017,36(2):129-136.

(10) Zhu X*, Shen K, Bai Y, Zhang A, Xia Z, Chao J, Yao H., NADPH oxidase activation is requiredfor pentylenetetrazole kindling-induced hippocampal autophagy. FreeRadic Biol Med.2016;94:230-42.

(11) Zhu X*, Dong J, Shen K, Bai Y, Chao J, Yao H., Neuronal nitric oxidesynthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis. Brain Res Bull. 2016, 24(1), 33-42.

(12) Zhu X, Dubey D, Bermudez C, Porter BE*., SuppressingcAMP response element-binding protein transcription shortens the duration ofstatus epilepticus and decreases the number of spontaneous seizures in thepilocarpine model of epilepsy. Epilepsia. 2015, 56(12):1870-1078

(13) Zhu X*, Dong J, Shen K, Bai Y, Zhang Y, Lv X, Chao J, Yao H., NMDA receptor NR2B subunits contributeto PTZ-kindling-induced hippocampal astrocytosisand oxidative stress.Brain Res Bull. 2015, 114:70-78.

(14) Bai Y^#, Zhu X^#, Chao J^#, Zhang Y, Qian C, Li P,Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, Yao H*.,Pericytes Contribute to the Disruption of theCerebral Endothelial Barrier via Increasing VEGF Expression: Implications forStroke, PLoS One, 2015; 10(4): e0124362

(15) Zhu XJ, HanX, Blendy, JA, Porter BE*. Decreased CREB levels suppress epilepsy. Neurobiol Dis. 2012, 253-263.

(16) Luo CX^#, Zhu XJ^#, Zhou QG^#, Wang B, Wang W, Cai HH, Sun YJ, HuM, Jiang J, Hua Y, Han X, Zhu DY*. Reduced neuronal nitric oxidesynthase is involved in ischemia-induced hippocampal neurogenesis byup-regulating inducible nitric oxide synthase expression. J Neurochem.2007, 103:1872-1882.

(17) Zhu XJ, Hua Y, Jiang J, Zhou QG, Luo CX, Han X, Lu YM, Zhu DY*., Neuronal nitric oxide synthase-derived nitricoxide inhibits neurogenesis inthe adult dentate gyrus by down-regulating cyclic AMP response element bindingprotein phosphorylation. Neuroscience.2006 , 141(2):827-836.

(18) Luo CX^#, Zhu XJ^#, Zhang AX^#, Wang W, Yang XM, Liu SH, Han X,Sun J, Zhang SG, Lu Y, Zhu DY*., Blockade of L-typevoltage-gated Ca channel inhibits ischemia-induced neurogenesis by down-regulating iNOS expression in adult mouse. J Neurochem.2005,94(4):1077-1086.

(19) Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, Zhu X, Huang W, Chao J, Zhou R, Hu G,Yao H*., Silencing microRNA-143protects the integrity of the blood-brain barrier: implications formethamphetamine abuse. Sci Rep.2016, 6:35642.

(20) Zhang Y, Lv X, Bai Y, ZhuX, Wu X, Chao J, Duan M, Buch S, Chen L, Yao H*., Involvement of sigma-1 receptor in astrocyte activation induced bymethamphetamine via up-regulation of its own expression. J Neuroinflammation.2015 12:29.

(21) Yi H, Bai Y, Zhu X,Lin L, Zhao L, Wu X, Buch S, Wang L, Chao J, Yao H*., IL-17A induces MIP-1α expression in primary astrocytes viaSrc/MAPK/PI3K/NF-kB pathways: implications for multiple sclerosis. JNeuroimmune Pharmacol.2014 , 9(5):629-641.

(22) WangIT, Allen M, GoffinD, Zhu X, Fairless AH, Brodkin ES, Siegel SJ, Marsh ED, Blendy JA, ZhouZ*.(2012) Loss of CDKL5 disrupts kinome profile and event-related potentialsleading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A, 2012, 109:21516-21521.

(23) Varodayan FP, Zhu XJ, Cui XN,Porter BE*.Seizures increase cell proliferation in the dentate gyrus by shorteningprogenitor cell-cycle length. Epilepsia,2009, 50: 2638-2647.

(24) Zhou QG, Hu Y, Hua Y, Hu M, Luo CX, Han X, Zhu XJ, Wang B, Xu JS, ZhuDY*., Neuronal nitric oxide synthase contributes tochronic stress-induced depression by suppressing hippocampal neurogenesis. J Neurochem. 2007,103(5):1843-54.\

(25) Lin X, Zhang Y*, Dong J, ZhuX, Ye M, Shi J, Lu J, Di Q, Shi J, Liu W., GM-CSF enhances neuraldifferentiation of bone marrow stromal cells.,Neuroreport.2007:18(11):1113-1117.

(26) Xin Jian Zhu, You Ming Lu, Dong Ya Zhu.Neuronal selfrepair following ischemic insults.Central nervous system Agents in Medicinal Chemistry. 2007,7:79-84.

(27) Luo CX, Zhu XJ, Zhou QG et al. Reduced neuronal nitric oxide synthase is involved inischemia-induced hippocampal neurogenesis by up- regulating inducible nitricoxide synthase expression. J Neurochem. 2007,103:1872-1882.

(28) Luo CX, Jiang J, Zhou QG, Zhu XJ, Wang W et al. Voluntary exercise-induced neurogenesis in thepostischemic dentate gyrus is associated with spatial memory recovery fromstroke. J Neurosci Res. 2007, 85:1637-1646.

(29) Lin X, Zhang Y, Dong J, Zhu X, Ye M et al. GM-CSF enhances neural differentiation of bone marrowstromal cells.Neuroreport. 2007, 16:1113-1117.

(30) Zhou QG, Hu Y,Hua Y, Hu M, Luo CX, Han X, Zhu XJ et al. Neuronalnitric oxide synthase contributes to chronic stress-induced depression bysuppressing hippocampal neurogenesis.J Neurochem. 2007,103:1843-1854.

(31)  Zhu XJ, Hua Y, Jiang J et al. Neuronal NOS-derived NO inhibits neurogenesis in the adult DG bydown-regulating CREB phosphorylation. Neuroscience. 2006,141:827-836.

(32) Luo CX, Zhu XJ, Zhang AX et al. Blockade of L-type voltage-gated Ca²⁺channel inhibits ischemia-induced neurogenesis by down-regulating iNOSexpression in adult mouse. J Neurochem. 2005, 94:1077-1086.