研究方向

端脑发育的调控与相关神经精神疾病的病理机制

   海马、新皮层是行使脑高级功能如学习记忆、情感的重要功能区域,多种认知和情感障碍均与早期海马以及新皮层神经环路的发育异常密切相关,但其发生发展机制尚不明了。本课题组在科技部973、863和国家自然基金的资助下,主要利用基因工程小鼠,通过基因敲除、转基因等手段揭示海马和新皮层神经环路发育过程中神经干细胞的分化、神经元迁移和成熟的调控机制,探讨环路中兴奋性神经元与抑制性中间神经元二者之间的平衡维持机制,旨在为深入理解脑高级功能的神经生物学基础及其相关疾病如学习记忆缺陷、癫痫以及其他神经发育疾病等的发生机制提供线索。

荣誉奖励

1    国家杰出青年科学基金资助

2    江苏省“333高层次人才培养工程”首批中青年科技领军人才

3    江苏省有突出贡献中青年专家

4    “新世纪百千万人才工程国家级人选

5    享受国务院政府特殊津贴专家

6    江苏省第三期“333”工程突出贡献奖

7    江苏省特聘教授

学术成果

1.Liu R, Yang Y, Shen J, Chen H, Zhang Q, Ba R, Wei Y, Li KC, Zhang X, ZhaoC*. Fstl1 is involved in the regulation of radial glial scaffold development. Molecular Brain. 2015 Sep 17;8(1):53. doi: 10.1186/s13041-015-0144-8.

2.LiuJ, LiuB, ZhangX, YuB, GuanW, WangK, YangY, GongY, WuX, YanagawaY, WuS, ZhaoC*. Calretinin-positive L5a pyramidal neurons in the development of the paralemniscal pathway in the barrel cortex. Molecular Brain. 2014, Nov 18, 7 (1) :84 , doi:10.1186/s13041-014-0084-8.

3.Wu X, Gu X, Han X, Du A, Jiang Y, Zhang X, Wang Y, Cao G, Zhao C*. A Novel Function for FoxM1 in Interkinetic Nuclear Migration in the Developing Telencephalon And Anxiety-related Behavior. The Journal of Neuroscience. 2014 Jan; 34(4):1510-1522.

4.Huang Y, Song NN, Lan W, Zhang Q, Zhang L, Zhang L, Hu L, Chen JY, Zhao C, Li L, Xu L, Ding YQ*. Sensory input is required for callosal axon targeting in the somatosensory cortex. Mol Brain. 2013 Dec 5;6(1):53.doi: 10.1186/1756-6606-6-53.

5.Nie B, Chen K, Zhao S, Liu J, Gu X, Yao Q, Hui J, Zhang Z, Teng G, Zhao C, Shan B* . A Rat Brain MRI Template with Digital Stereotaxic Atlas of Fine Anatomical Delineations in Paxinos Space and its Automated Application in Voxel-Wise Analysis. Human Brain Mapping. 2013 Jun;34(6):1306-18.

6.Tian C, Gong Y, Yang Y, Shen W, Wang K, Liu J, Xu B, Zhao J, Zhao C*. Foxg1 Has An essential Role in Postnatal Development of The Dentate gyrus. The Journal of Neuroscience. 2012. Feb., 32(9):2931-2949.

7.Gu X, Liu B, Wu X, Yan Y, Zhang Y, Wei Y,. Pleasure SJ, Zhao C*. Inducible Genetic Lineage Tracing of Cortical Hem Derived Cajal-Retzius Cells Reveals Novel Properties. PLoS ONE. 2011;6(12):e28653. (recommended by F 1000)

8.Li Y, Tian C, Yang Y, Yan Y, Ni Y, Wei Y, Pleasure SJ, Zhao C*. An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis. Genesis. 2011 Dec. 49 (12):919-926.

9.Zhou W, Zhang Y, Li Y, Wei YS, Liu G, Liu DP, Pleasure SJ, Xie W, Zhao C*. A transgenic Cre Mouse Line for the Study of Cortical And Hippocampal Development. Genesis. 2010 May; 48(5): 343-50.

10.Yang Y, Liu J, Mao H, Hu YA, Yan Y, Zhao C*.The Expression Pattern of Follistatin-Like 1 in Mouse Central Nervous System Development. Gene Expr Patterns. 2009 Oct; 9(7):532-540.

11.Gu X, Yan Y, Li H, He D, Pleasure SJ, Zhao C*.Characterization of the Frizzled10-CreERTM Transgenic Mouse: An Inducible Cre Line for the Study of Cajal–Retzius Cell Development. Genesis. 2009 Mar; 47(3): 210 – 216.

12.Yan Y, Li Y, Hu C, Gu X, Liu J, Hu YA, Yang Y, Wei Y, Zhao C*. Expression of Frizzled10 in mouse nervous system. Gene Expr Patterns. 2009 Mar; 9 (3):173-177.

13.Hu C, Liu J, Zhang Y, Li Y, Xie W, Zhao C*. A useful transgenic mouse line for studying the development of spinal nociceptive circuits.Neuroscience lett. 2009 Jan 30; 450 (2):211-216.

14.Gu X, He D, Li Y, Hu C, Wei YS, Liu G, Liu D, Pleasure SJ, Xie W, Zhao C*. Generation of Frizzled10-Cre Transgenic Mouse Line: A Useful Tool for the Study of Dorsal Telencephalic Development. Genesis.2008 Oct; 46 (10):523-9.

15.Hu YA, Gu X, Liu J, Yang Y, Yan Y, Zhao C*. Expression pattern of wnt inhibitor factor 1(wif1) during the development in mouse CNS.Gene Expr Patterns.2008 Sep; 8 (7-8): 515-522.

16.Zhao C, Guan W, Pleasure SJ*. A Transgenic Marker Mouse Line Labels Cajal-Retzius Cells from the Cortical Hem and Thalamocortical axons.Brain Res. 2006 Mar 10; 1077 (1):48-53. (cover story)

17.Zhao C*, Avilés C, Abel RA, Almli CR, McQuillen P, Pleasure SJ*. Hippocampal and Visuospatial Learning Defects in Mice with Deletion of Frizzled9, a Gene in the Williams Syndrome Deletion Interval.Development.2005 Jun; 132(12):2917-2927.

18.Zhao C*, Pleasure SJ*.Frizzled9 Protein Is Regionally Expressed in the Developing Medial Wall of the Cortex and the Cells Derived from This Region.Developmental Brain Research. 2005 Jun 9; 157 (1):93-97.

19.Zhao C, Pleasure SJ*.The Frizzled9 Promoter Drives Expression of Transgenes in the Medial Wall of the Cortex and Its Chief Derivative the Hippocampus. Genesis.2004 Sep; 40(1):32-9.

20.Zhou CJ, Zhao C, Pleasure SJ*.Wnt Signaling Mutants Have Decreased Dentate Granule Cell Production And Radial Glial Scaffold Abnormalities. The Journal of Neuroscience.  2004 Jan 7;24(1):121-126.

21.Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N*. Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1B. Cell. 2001 Jun 1;105(5):587-597.cover story