研究方向

1.非编码RNA(non-coding RNA, ncRNA)是一类不编码蛋白质的RNA分子,其中长度大于200nt的称为长链非编码RNA(long non-coding RNA,lncRNA),近年来关于lncRNA对生命进程的调控功能的研究进展迅速,这些研究均表明lncRNA可以以RNA的形式参与了X染色体沉默、基因组印记、核内运输、转录激活与干扰等重要的过程,目前绝大多数lncRNA的功能仍然是未知的。大量研究表明,在肿瘤细胞中有某些特定的lncRNA表达水平发生改变,这种改变使其能够成为肿瘤诊断的标志物与潜在的药物靶点。我们实验室将集中于寻找肿瘤中异常表达的lncRNA

2.传统抗体分子量大,结构复杂,由此产生的高昂成本也限制了其在临床上的应用。目前基于骆驼重链抗体的VHH单域抗体研究成为热点,由于其在水溶液中的良好的稳定性,弱的免疫原性,良好的组织穿透性,使该抗体在基础研究,药物开发等领域具有广阔的应用前景。

荣誉奖励
学术成果

1.Shufeng li, Fang ma, Kunpeng jiang, Haitao shan,Minke shi, Baojun chen. lncRNA malat1 promotes lung adenocarcinoma by directly interacting with SP1. Cancer Science. In press.(第一兼通讯作者)

2.Anran Liu, Haitao Shan, Mengyao Ma, LiShangguan, Kunpeng Jiang, Minke Shi, Yuewu Zhao, Songqin Liua, Shufeng Li. Anultrasensitive photoelectrochemical immunosensor by integration of nanobody,TiO2 nanorod arrays and ZnS nanoparticles for the detection of tumor necrosisfactor-α. Journal of Electroanalytical Chemistry 803 (2017) 110(通讯作者)

3. Shufeng Li, Yifan Chen, Haitao Shan,Fang Ma, Minke Shi, Jun Xue. Novel heterozygous NOTCH3 pathogenic variant foundin two Chinese patients with CADASIL. Journal of ClinicalNeuroscience 46 (2017) 8589(第一兼通讯作者)

4..Lishufeng,Qiangqian,Shanhaitao,Shiminke,Ganguangming,Mafang,Chenbaojun. Mir20a and miR20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancercells. Life Sci. 2016,147:143-152(第一兼通讯作者)

5.ShufengLi,QiweiWang,QianQiang,HaitaoShan,Minke Shi,BaojunChen. Sheng Zhao,Liudi Yuan.Sp1 mediated transcriptional regulation of MALAT1 plays a critical rolein tumor. J Cancer Res ClinOncol(2015)141:1909–1920 (第一兼通讯作者)

6.HaoYu, Shufeng Li, LiandongFeng, Yucheng Liu, Xiaoliang Qi, Wei Wei, Junjian Li, and Wei Dong,Diglycidyl Esters CrossLinked with LowMolecularWeight Polyethyleneimine for Magnetofection. Aust. J.Chem.2015.http://dx.doi.org/10.1071/CH14731(并列第一作者)

7.YuchengLiu,ShufengLi,LiandongFeng,HaoYu,XiaoliangQi,WeiWei,JunjianLi,andWeiDong, Novel Disulfide-Containing Poly(b-aminoester Functionalised Magnetic Nanoparticles for Efficient Gene Delivery. Aust. J. Chem. 2015.http://dx.doi.org/10.1071/CH14731 (并列第一作者)

8.ShufengLi, Jun Xue,Baojun Chen, Qiwei Wang, Minke Shi,Xiaojing Xie, Liang Zhang. Two middle-age-onset hemochromatosis patients with heterozygous mutations in the hemojuvelingene in a Chinese family. Int J Hematol 2014;99: 487-492(第一兼通讯作者)

9.LiS, Huang X, Zhang D, Huang Q, Pei G, Wang L, Jiang W, Hu Q,Tan R, Hua ZC. Requirement of PEA3 for transcriptional activation of FAK gene in tumor metastasis. PLoS One. 2013;8(11):e79336:1-13. (第一作者)

10.LiS, Dong W, ZongY, Yin W, JinG, Hu Q, Huang X, Jiang W, Hua ZC.Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics. Mol Ther.2007 Mar;15(3):515-23. (第一作者)

11.LiS, Li J, Cheng J, Zhou B, Tong X, Dong X, Wang Z, Hu Q, Chen M,HuaZC. Nonsyndromic tooth agenesis in two Chinese families associated with novel missense mutations in the TNF domain of  EDA  (ectodysplasin A).  PLoS One.2008 Jun 11;3(6) (第一作者)

12.LiS, Hua ZC.FAK expression regulation and therapeutic potential. Adv Cancer Res. 2008;101:45-61. (第一作者)

13.Dong W, Li SF,JinGH, Sun QM , Ma DY, Hua ZC. Efficient genetransfection into mammalian cellsmediated by cross-linked polyethylenimine. Int J MolSci 2006;7:1-32. (并列第一作者)