研究方向

肿瘤干细胞及肿瘤免疫;感染免疫及核酸疫苗

荣誉奖励

1997年获浙江大学医学博士学位;1999年-2015年先后7次留学和高访德国乌尔姆大学和美国CDC、佐治亚大学、耶鲁大学共3年。

2004年江苏省六大高峰人才;先后获省厅科研奖4项,东南大学教学奖4项,东南大学教学名师;2011年东南大学优秀共产党员。

现为医学院病原生物学与免疫学系主任,二级教授。东南大学生命科学与医学学部委员。

学术成果

发表各类论文221篇,其中SCI论文第一作者、第一作者兼通讯作者或通讯作者60余篇。

1.Downregulated lncRNA HOTAIR expression in ovarian cancer stem cells decreases its tumorgeniesis and metastasis by inhibiting epithelial-mesenchymal transition. Cancer Cell Int 2015;15:24通讯作者
2. Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model. Oncotarget. 2015;6:27714-24通讯作者
3.Decrease of ZEB1 expression inhibits the B16F10 cancer stem-like properties. Biosci Trends. 2015;9:325-34通讯作者
4. Effect of targeted ovarian cancer immunotherapy using ovarian cancer stem cell vaccine.J Ovarian Res. 2015;8:68通讯作者
5. Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells. J Drug Target. 2015;23:1-13通讯作者
6. Combining TGF-β1 knockdown and miR200c administration to optimize antitumor efficacy of B16F10/GPI-IL-21 vaccine. Oncotarget. 2015;6:12493-504. 通讯作者
7. Cancer stem cell vaccine expressing ESAT-6-gpi andIL-21 inhibits melanoma growth and metastases. Am J Transl Res 2015;7(10):1870-1882通讯作者
8. Decreasing lncRNA HOTAIR expression to inhibit human colorectal cancer stem cells. Am J Transl Res 2015; Nov 23 Accepted 第一兼通讯作者
9. Advances and perspectives in colorectal cancer stem cell vaccine . Biomedicine & Pharmacotherapy 2015;76: 107-120通讯作者
10. Downregulation of β-catenin decreases the tumorigenicity, but promotes epithelial-mesenchymal transition in breast cancer cells. J Cancer Res Ther. 2014;10:1063-70通讯作者
11.Gene therapy of ovarian cancer using IL-21secreting human umbilical cord mesenchymal stem cells in nude mice. J Ovarian Res 2014;7:8 通讯作者
12. Anti-ABCG2 Monoclonal Antibody in Combination with Paclitaxel-Nanoparticles Against Cancer Stem-like Cell Activity in Multiple Myeloma. Nanomedicine (Lond) 2014; 9:45-60 通讯作者
13.γ-Fe2O3 Nanoparticles Increase the Therapeutic Efficacy of Combination with Paclitaxel and Anti-ABCG2 Monoclonal Antibody on Multiple Myeloma Cancer Stem Cells in Mouse Model. J Biomed Nanotechnol 2014;10, 336-44通讯作者
14.Regulation gene expression of miR200c and ZEB1 positively enhances effect of tumor vaccine B16F10/GPI-IL-21 on inhibition of melanoma growth and metastasis. J Transl Med 2014; 12: 68 通讯作者
15. Observation of ovarian cancer stem cell behavior and investigation of potential mechanisms of drug resistance in three dimensional cell culture. J Biosci Bioeng 2014; 118: 214-222通讯作者
16. MiR-7, Inhibited Indirectly by LincRNA HOTAIR, Directly Inhibits SETDB1 and Reverses the EMT of Breast Cancer Stem Cells by Downregulating the STAT3 Pathway. Stem Cell 2014; 32:2858-68. 通讯作者
17. Effect of downregulation of ZEB1 on vimentin expression, tumor migration and tumorigenicity of melanoma B16F10 cells and CSCs. Cell Biol Int 2014;38:452-61第一兼通讯作者
18. ESAT-6-gpi DNA vaccine augment the specific anti-tumor efficacy induced by the tumor vaccine B16F10-ESAT-6-gpi/IL-21 in mice. Scand J Immunol 2013; 78: 69-78 通讯作者
19. Effect of downregulated transcriptional repressor ZEB1 on the epithelial- mesenchymal transition of ovarian cancer cells. Int J Gynecol Cancer.  2013; 23:1357-66. 通讯作者
20. Paclitaxel-Fe3O4 nanoparticles inhibits the growth of CD138CD34 Tumor Stem-like cells in multiple myeloma bearing mice. Int J Nanomed  2013;8: 1439-1449 通讯作者
21. Overexpression of micro-200c in CD44+CD133+ CSCs inhibits the Cellular migratory and invasion as well as tumorigenicity in mice. Cell Mol Biol. 2013; 59: OL1861-OL1868第一兼通讯作者
22. Evaluation of characteristics of CD117CD44 ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures. BMC Cell Biol. 2013; 31;14:7 通讯作者
23. Effect of Paclitaxel-Nanoparticles on CD138-CD34- Cancer Stem-like cells in multiple myeloma cell lines in vitro. J Nanopart Res. 2013 15:1840通讯作者
24. MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial- mesenchymal transition. J Ovarian Res. 2013;6:50. 通讯作者
25.Targeted therapeutic effect of anti-ABCG2 antibody combined with nano silver and vincristine on mouse myeloma cancer stem cells. J Nanopart Res. 2013; 15:2127第一兼通讯作者
26. Poly(ethylene glycol)-cross linked poly(methyl vinyl ether-co-maleic acid)hydrogels for three-dimensional human ovarian cancer cell culture. Colloids and Surfaces A: Physicochem Eng Aspects. 2013; 422: 81-9第四作者
27. Protection against Mycobacterium tuberculosis challenge in mice by DNA vaccine Ag85A-ESAT-6-IL-21 priming and BCG boosting. Int J Immunogenet.2012; 39 :183-90 第一兼通讯作者
28. Downregulation of gene MDR1 by shRNA to reverse multidrug- resistance of ovarian cancer A2780 cells. J Can Res Ther 2012;8:226-31通讯作者
29. Nanoparticle-based adjuvant for enhanced protective efficacy of DNA vaccine Ag85A-ESAT-6-IL-21 against Mycobacterium tuberculosis infection.  Nanomedicine. 2012; 8: 1337-44通讯作者
30. Anti-tumor Efficacy of Viable Tumor Vaccine Modified by Heterogenetic ESAT-6 Antigen and Cytokine IL-21 in Melanomatous Mouse.  Immunol Res. 2012; 52:240-249通讯作者
31. A Preliminary Investigation of the Relationship between Circulation Tumor Cells and Cancer Stem Cells in Patients with Brest Cancer. Cell Mol Biol. 2012;58 : OL1641-45通讯作者
32. Using ABCG2-molecule-expressing side population cells to identify cancer stem-like cells in a human ovarian cell line. Cell Biol Int 2011;35:227-34第一兼通讯作者
33. Immunotherapy of melanoma by GPI- anchored IL-21 tumor vaccine involves down- regulating regulatory T cells in mouse model. Int J Immunogenet 2011; 38:21-9通讯作者
34. Augmenting Therapy of Ovarian Cancer Efficacy by Secreting IL-21 Human Umbilical Cord Blood Stem Cells in Nude Mice. Cell Transplatation 2011; 20: 669-80通讯作者
35. An ocular mucosal administration of nanocarriers containing DNA vaccine pRSC- gD-IL-21 confers protection against mucosal challenge with herpes simplex virus type 1 in mice. Vaccine 2011;29:1455-62通讯作者
36. Immunization with DNA Vaccine Expressing Herpes Simplex Virus Type 1 gD and IL-21 Protects against Mouse Herpes Keratitis. Immunol Invest 2011; 40:265-78通讯作者
37. Human umbilical blood-derived mesenchymal stem cells as IL-21 gene delivery vehicles for epithelial ovarian cancer therapy in nude mice. BIOTECHNOL APPL BIOC 2011; 58:397-404通讯作者
38. Anti-tumor efficacy induced by B16F10 tumor cell vaccine treated with mitoxantrone alone or in combination with reserpine and verapamil in mice. Exp Ther Med 2011; 2: 911-16通讯作者
39. Effect of downregulated β-catenin on cell proliferative activity, the sensitivity to chemotherapy drugs and tumorigenicity of ovarian cancer cells. Cell Mol Biol 2011; 57: OL1606-13 通讯作者
40. Advances in the Analysis of Hepatitis C Virus Specific T Cell Responses. Mini Rev Med Chem 2011;11:106-113第二作者
41. Emerging strategies for the identification and targeting of cancer stem cells. Tumor Biol 2010; 31:243-53 第一兼通讯作者
42. Investigation on the anti-tumor efficacy by expression of GPI-anchored mIL-21 on the surface of B16F10 cells in C57BL/6 mice. Immunobiology 2010; 215:89-100 通讯作者
43. Investigation of immune effect based on BCG priming and Plasmid DNA expressing Ag85A & GM-CSF boosting in Balb/c mice Model. Immunobiology 2010; 215:133-42第一兼通讯作者
44. Eliciting protective immune responses against murine myeloma challenge in lymphopenia mice through adoptive transfer of tumor antigen-specific lymphocytes and immunization of tumor vaccine secreting mIL-21. Cancer Gene Ther 2010; 17:675-83第一兼通讯作者
45. Enhancing therapy of melanoma efficacy via tumor cell vaccine expressing GPI-anchored IL-21 and secreting GM-CSF in mouse model. Vaccine 2010; 28 :2486-52 通讯作者
46. Antitumor efficacy induced by human ovarian cancer secreting IL-21 alone or combination with GM-CSF cytokines in nude mice model. Immunobiology 2009; 214:483-92第一兼通讯作者
47. Identifying tumor stem-like cells in mouse melanoma cell lines by analyzing the characteristics of side population cells. Cell Biol Int 2009; 33:807-15. 第一兼通讯作者
48. Identification of tumor stem like cells in mouse myeloma cell lines. Cell Mol Biol 2009;55 :OL1151-60第一兼通讯作者
49. Characterization of the Cellular Immune Response in Hepatitis C Virus Infection. Med Res Rev. 2009;29:843-66 第二作者
50. Comparison of immune responses induced in mice by vaccination with DNA vaccine constructs expressing Mycobacterial antigen 85A & Interleukin-21 and Bacillus Galmette-Guérin. Immunol Invest 2008; 37:113-27第一兼通讯作者
51. Study of immunotherapy of murine myeloma by an IL-21-based tumor vaccine in Balb/c mice. Cancer Biology & Therapy 2007. 6:12, 1871-79第一兼通讯作者
52. Isolation and identification of cancer stem-like cells from murine melanoma cell lines. Cell Mol Immunol2007;4: 467-472第一兼通讯作者
53. Investigation of GM-CSF Immune Accessory Effects in Tumor-Bearing Mice by Direct Gene Immunization. Immunol Invest 2006; 35: 227-37第一兼通讯作者
54. Effect of hepatitis C virus core shadow protein expressed in human hepatoma cell line on human gene expression profiles. J Gastro Hepat 2006; 21:1794-800第一兼通讯作者
55. Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV. Cell Mol Immunol 2006; 3:227-33第一兼通讯作者
56. Cellular response to gene expression profiles of different hepatitis C virus core protein in Huh-7 cell line with microarray analysis. J Nanosci Nanotechnol 2005;5: 1230-35第一兼通讯作者
57. Inhibition effect of Chinese herbal medicine on transcription of hepatitis C virus structural gene in vitro. WJG 2005;11:3619-22第一兼通讯作者
58.Novel constructs of tuberculosis gene vaccine and its immune effect in mice. Cell Mol Immunol 2005;2:88-93 第一兼通讯作者
59. Preliminary study on mouse interleukin 21 application in tumor gene therapy. Cell Mol Immunol 2004,1:461-66  第一兼通讯作者
60. Investigation of Human Parvovirus B19 Infection in Pregnant Women and their Newborns. J Microbiol Immunol 2004;2:312-15 通讯作者
61. The relation between peripheral blood mononuclear cell proliferation responses to HCV synthetic peptide in hepatitis C patients with IFN curative.  Chin Med J 2001 network version第一作者
62. Effect of immunization in mice with recombinant DNA encoding the hepatitis C virus structural protein.
Chin Med J  1999;112:1036-9 第一作者

近年获得专利

1.肿瘤干细胞疫苗及其制备方法。专利号 201510411411.4 排名1

2. 一种卵巢癌干细胞疫苗及其制备方法。 专利号 201510553477.7 排名1

3. 紫杉醇磁性纳米粒及其制备方法和用途专利号201210397824.8排名4

4. 一种用于肿瘤细胞三维培养的水凝胶的制备方法。专利号201110210036.9 排名4  

近年发表专著

1.参编 肿瘤免疫。见医学免疫学科学出版社P183-191, 2013 第一作者

2.参编 Biomarkers of Cancer Stem Cells. In: Roberto Scatena, Alvaro Mordente, and Bruno Giardina (Editor-in-Chief ) “Advance in Cancer Stem Cells” Published bySpringer ISBN 978-1-4614-0808-6 P45-68, 2011 第一作者

3. 参编 Latest Therapeutic Approaches Based on Cancer Stem Cells. In: Stanley Shostak (Editor-in- Chief ) “Cancer Stem Cells - The Cutting Edge” Published by InTech.ISBN 978-953-307-1454-5P389-406, 2011第一作者

4. 主编 肿瘤干细胞东南大学出版社ISBN 978-7-5641-1726-9 2009

5. 主编 疫苗工程学I版,东南大学出版社ISBN 978-7-5641-0969-1 2007;

6. 主编疫苗工程学 II版, 东南大学出版社 ISBN 978-7-5641-5154-7 2014 (江苏省重点教材).