研究方向

肿瘤干细胞及肿瘤免疫;感染免疫及核酸疫苗

荣誉奖励

1999年获浙江大学医学院优秀博士论文

2000年获浙江省科技进步二等奖

2004年获东南大学教学优秀二等奖

2004年获江苏省六大高峰人才

2005年获东南大学三育人奖

2006年获东南大学教学优秀一等奖

2006年东南大学丁家桥校区优秀党员

2006年获科技发展中心中国科技论文在线编辑部推荐的优秀学者

2009年获东南大学教学优秀二等奖

2011年获东南大学教学优秀一等奖

2011年获东南大学教学名师

2011年获东南大学优秀共产党员

2016年获东南大学教学优秀一等奖

学术成果

发表各类论文221篇,其中SCI论文第一作者、第一作者兼通讯作者或通讯作者60余篇。

1.Downregulated lncRNA HOTAIR expression in ovarian cancer stem cells decreases its tumorgeniesis and metastasis by inhibiting epithelial-mesenchymal transition. Cancer Cell Int 2015;15:24通讯作者
2. Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model. Oncotarget. 2015;6:27714-24通讯作者
3.Decrease of ZEB1 expression inhibits the B16F10 cancer stem-like properties. Biosci Trends. 2015;9:325-34通讯作者
4. Effect of targeted ovarian cancer immunotherapy using ovarian cancer stem cell vaccine.J Ovarian Res. 2015;8:68通讯作者
5. Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells. J Drug Target. 2015;23:1-13通讯作者
6. Combining TGF-β1 knockdown and miR200c administration to optimize antitumor efficacy of B16F10/GPI-IL-21 vaccine. Oncotarget. 2015;6:12493-504. 通讯作者
7. Cancer stem cell vaccine expressing ESAT-6-gpi andIL-21 inhibits melanoma growth and metastases. Am J Transl Res 2015;7(10):1870-1882通讯作者
8. Decreasing lncRNA HOTAIR expression to inhibit human colorectal cancer stem cells. Am J Transl Res 2015; Nov 23 Accepted 第一兼通讯作者
9. Advances and perspectives in colorectal cancer stem cell vaccine . Biomedicine & Pharmacotherapy 2015;76: 107-120通讯作者
10. Downregulation of β-catenin decreases the tumorigenicity, but promotes epithelial-mesenchymal transition in breast cancer cells. J Cancer Res Ther. 2014;10:1063-70通讯作者
11.Gene therapy of ovarian cancer using IL-21secreting human umbilical cord mesenchymal stem cells in nude mice. J Ovarian Res 2014;7:8 通讯作者
12. Anti-ABCG2 Monoclonal Antibody in Combination with Paclitaxel-Nanoparticles Against Cancer Stem-like Cell Activity in Multiple Myeloma. Nanomedicine (Lond) 2014; 9:45-60 通讯作者
13.γ-Fe2O3 Nanoparticles Increase the Therapeutic Efficacy of Combination with Paclitaxel and Anti-ABCG2 Monoclonal Antibody on Multiple Myeloma Cancer Stem Cells in Mouse Model. J Biomed Nanotechnol 2014;10, 336-44通讯作者
14.Regulation gene expression of miR200c and ZEB1 positively enhances effect of tumor vaccine B16F10/GPI-IL-21 on inhibition of melanoma growth and metastasis. J Transl Med 2014; 12: 68 通讯作者
15. Observation of ovarian cancer stem cell behavior and investigation of potential mechanisms of drug resistance in three dimensional cell culture. J Biosci Bioeng 2014; 118: 214-222通讯作者
16. MiR-7, Inhibited Indirectly by LincRNA HOTAIR, Directly Inhibits SETDB1 and Reverses the EMT of Breast Cancer Stem Cells by Downregulating the STAT3 Pathway. Stem Cell 2014; 32:2858-68. 通讯作者
17. Effect of downregulation of ZEB1 on vimentin expression, tumor migration and tumorigenicity of melanoma B16F10 cells and CSCs. Cell Biol Int 2014;38:452-61第一兼通讯作者
18. ESAT-6-gpi DNA vaccine augment the specific anti-tumor efficacy induced by the tumor vaccine B16F10-ESAT-6-gpi/IL-21 in mice. Scand J Immunol 2013; 78: 69-78 通讯作者
19. Effect of downregulated transcriptional repressor ZEB1 on the epithelial- mesenchymal transition of ovarian cancer cells. Int J Gynecol Cancer.  2013; 23:1357-66. 通讯作者
20. Paclitaxel-Fe3O4 nanoparticles inhibits the growth of CD138CD34 Tumor Stem-like cells in multiple myeloma bearing mice. Int J Nanomed  2013;8: 1439-1449 通讯作者
21. Overexpression of micro-200c in CD44+CD133+ CSCs inhibits the Cellular migratory and invasion as well as tumorigenicity in mice. Cell Mol Biol. 2013; 59: OL1861-OL1868第一兼通讯作者
22. Evaluation of characteristics of CD117CD44 ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures. BMC Cell Biol. 2013; 31;14:7 通讯作者
23. Effect of Paclitaxel-Nanoparticles on CD138-CD34- Cancer Stem-like cells in multiple myeloma cell lines in vitro. J Nanopart Res. 2013 15:1840通讯作者
24. MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial- mesenchymal transition. J Ovarian Res. 2013;6:50. 通讯作者
25.Targeted therapeutic effect of anti-ABCG2 antibody combined with nano silver and vincristine on mouse myeloma cancer stem cells. J Nanopart Res. 2013; 15:2127第一兼通讯作者
26. Poly(ethylene glycol)-cross linked poly(methyl vinyl ether-co-maleic acid)hydrogels for three-dimensional human ovarian cancer cell culture. Colloids and Surfaces A: Physicochem Eng Aspects. 2013; 422: 81-9第四作者
27. Protection against Mycobacterium tuberculosis challenge in mice by DNA vaccine Ag85A-ESAT-6-IL-21 priming and BCG boosting. Int J Immunogenet.2012; 39 :183-90 第一兼通讯作者
28. Downregulation of gene MDR1 by shRNA to reverse multidrug- resistance of ovarian cancer A2780 cells. J Can Res Ther 2012;8:226-31通讯作者
29. Nanoparticle-based adjuvant for enhanced protective efficacy of DNA vaccine Ag85A-ESAT-6-IL-21 against Mycobacterium tuberculosis infection.  Nanomedicine. 2012; 8: 1337-44通讯作者
30. Anti-tumor Efficacy of Viable Tumor Vaccine Modified by Heterogenetic ESAT-6 Antigen and Cytokine IL-21 in Melanomatous Mouse.  Immunol Res. 2012; 52:240-249通讯作者
31. A Preliminary Investigation of the Relationship between Circulation Tumor Cells and Cancer Stem Cells in Patients with Brest Cancer. Cell Mol Biol. 2012;58 : OL1641-45通讯作者
32. Using ABCG2-molecule-expressing side population cells to identify cancer stem-like cells in a human ovarian cell line. Cell Biol Int 2011;35:227-34第一兼通讯作者
33. Immunotherapy of melanoma by GPI- anchored IL-21 tumor vaccine involves down- regulating regulatory T cells in mouse model. Int J Immunogenet 2011; 38:21-9通讯作者
34. Augmenting Therapy of Ovarian Cancer Efficacy by Secreting IL-21 Human Umbilical Cord Blood Stem Cells in Nude Mice. Cell Transplatation 2011; 20: 669-80通讯作者
35. An ocular mucosal administration of nanocarriers containing DNA vaccine pRSC- gD-IL-21 confers protection against mucosal challenge with herpes simplex virus type 1 in mice. Vaccine 2011;29:1455-62通讯作者
36. Immunization with DNA Vaccine Expressing Herpes Simplex Virus Type 1 gD and IL-21 Protects against Mouse Herpes Keratitis. Immunol Invest 2011; 40:265-78通讯作者
37. Human umbilical blood-derived mesenchymal stem cells as IL-21 gene delivery vehicles for epithelial ovarian cancer therapy in nude mice. BIOTECHNOL APPL BIOC 2011; 58:397-404通讯作者
38. Anti-tumor efficacy induced by B16F10 tumor cell vaccine treated with mitoxantrone alone or in combination with reserpine and verapamil in mice. Exp Ther Med 2011; 2: 911-16通讯作者
39. Effect of downregulated β-catenin on cell proliferative activity, the sensitivity to chemotherapy drugs and tumorigenicity of ovarian cancer cells. Cell Mol Biol 2011; 57: OL1606-13 通讯作者
40. Advances in the Analysis of Hepatitis C Virus Specific T Cell Responses. Mini Rev Med Chem 2011;11:106-113第二作者
41. Emerging strategies for the identification and targeting of cancer stem cells. Tumor Biol 2010; 31:243-53 第一兼通讯作者
42. Investigation on the anti-tumor efficacy by expression of GPI-anchored mIL-21 on the surface of B16F10 cells in C57BL/6 mice. Immunobiology 2010; 215:89-100 通讯作者
43. Investigation of immune effect based on BCG priming and Plasmid DNA expressing Ag85A & GM-CSF boosting in Balb/c mice Model. Immunobiology 2010; 215:133-42第一兼通讯作者
44. Eliciting protective immune responses against murine myeloma challenge in lymphopenia mice through adoptive transfer of tumor antigen-specific lymphocytes and immunization of tumor vaccine secreting mIL-21. Cancer Gene Ther 2010; 17:675-83第一兼通讯作者
45. Enhancing therapy of melanoma efficacy via tumor cell vaccine expressing GPI-anchored IL-21 and secreting GM-CSF in mouse model. Vaccine 2010; 28 :2486-52 通讯作者
46. Antitumor efficacy induced by human ovarian cancer secreting IL-21 alone or combination with GM-CSF cytokines in nude mice model. Immunobiology 2009; 214:483-92第一兼通讯作者
47. Identifying tumor stem-like cells in mouse melanoma cell lines by analyzing the characteristics of side population cells. Cell Biol Int 2009; 33:807-15. 第一兼通讯作者
48. Identification of tumor stem like cells in mouse myeloma cell lines. Cell Mol Biol 2009;55 :OL1151-60第一兼通讯作者
49. Characterization of the Cellular Immune Response in Hepatitis C Virus Infection. Med Res Rev. 2009;29:843-66 第二作者
50. Comparison of immune responses induced in mice by vaccination with DNA vaccine constructs expressing Mycobacterial antigen 85A & Interleukin-21 and Bacillus Galmette-Guérin. Immunol Invest 2008; 37:113-27第一兼通讯作者
51. Study of immunotherapy of murine myeloma by an IL-21-based tumor vaccine in Balb/c mice. Cancer Biology & Therapy 2007. 6:12, 1871-79第一兼通讯作者
52. Isolation and identification of cancer stem-like cells from murine melanoma cell lines. Cell Mol Immunol2007;4: 467-472第一兼通讯作者
53. Investigation of GM-CSF Immune Accessory Effects in Tumor-Bearing Mice by Direct Gene Immunization. Immunol Invest 2006; 35: 227-37第一兼通讯作者
54. Effect of hepatitis C virus core shadow protein expressed in human hepatoma cell line on human gene expression profiles. J Gastro Hepat 2006; 21:1794-800第一兼通讯作者
55. Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV. Cell Mol Immunol 2006; 3:227-33第一兼通讯作者
56. Cellular response to gene expression profiles of different hepatitis C virus core protein in Huh-7 cell line with microarray analysis. J Nanosci Nanotechnol 2005;5: 1230-35第一兼通讯作者
57. Inhibition effect of Chinese herbal medicine on transcription of hepatitis C virus structural gene in vitro. WJG 2005;11:3619-22第一兼通讯作者
58.Novel constructs of tuberculosis gene vaccine and its immune effect in mice. Cell Mol Immunol 2005;2:88-93 第一兼通讯作者
59. Preliminary study on mouse interleukin 21 application in tumor gene therapy. Cell Mol Immunol 2004,1:461-66  第一兼通讯作者
60. Investigation of Human Parvovirus B19 Infection in Pregnant Women and their Newborns. J Microbiol Immunol 2004;2:312-15 通讯作者
61. The relation between peripheral blood mononuclear cell proliferation responses to HCV synthetic peptide in hepatitis C patients with IFN curative.  Chin Med J 2001 network version第一作者
62. Effect of immunization in mice with recombinant DNA encoding the hepatitis C virus structural protein.
Chin Med J  1999;112:1036-9 第一作者

近年获得专利

1.肿瘤干细胞疫苗及其制备方法。专利号 201510411411.4 排名1

2. 一种卵巢癌干细胞疫苗及其制备方法。 专利号 201510553477.7 排名1

3. 紫杉醇磁性纳米粒及其制备方法和用途专利号201210397824.8排名4

4. 一种用于肿瘤细胞三维培养的水凝胶的制备方法。专利号201110210036.9 排名4  

近年发表专著

1.参编 肿瘤免疫。见医学免疫学科学出版社P183-191, 2013 第一作者

2.参编 Biomarkers of Cancer Stem Cells. In: Roberto Scatena, Alvaro Mordente, and Bruno Giardina (Editor-in-Chief ) “Advance in Cancer Stem Cells” Published bySpringer ISBN 978-1-4614-0808-6 P45-68, 2011 第一作者

3. 参编 Latest Therapeutic Approaches Based on Cancer Stem Cells. In: Stanley Shostak (Editor-in- Chief ) “Cancer Stem Cells - The Cutting Edge” Published by InTech.ISBN 978-953-307-1454-5P389-406, 2011第一作者

4. 主编 肿瘤干细胞东南大学出版社ISBN 978-7-5641-1726-9 2009

5. 主编 疫苗工程学I版,东南大学出版社ISBN 978-7-5641-0969-1 2007; /div>