研究方向

认知障碍的神经影像学研究

(对学生要求:刻苦专研的精神,智商、情商与挫折商合理的结合)

荣誉奖励

(1)   2016年江苏省优秀青年基金获得者

(2)  2016年江苏省第五期“333工程”第三层次培养对象

(3)  2015年江苏省“六大人才高峰”高层次人才

(4)  2015年江苏省医学新技术引进奖一等奖:多模态脑影像技术在老年期抑郁和痴呆共病诊断中的应用价值(No.2015-11-2,排二)

(5) 2014年江苏省医学新技术引进奖一等奖:多模态fMRIAD风险人群痴呆转化中的早期预警价值”(排一)

(6) 2014年南京市科技进步奖二等奖:神经影像技术在阿尔茨海默病早期诊断中的应用”(排一)

(7) 2014年东南大学五四青年奖章”

(8) 2014年中华医学科技奖三等奖:抑郁症的共病诊断、治疗及发病机制研究”(排六,No. 201403175P0806

(9)  2013年教育部新世纪优秀人才”

(10) 2013年全国优秀博士学位论文提名奖:遗忘型轻度认知障碍患者多模态磁共振成像研究”

(11) 2011年中华医学科技奖一等奖:精神疾病认知障碍的发生机制与临床研究”(排五,No. 201101170P1505

(12) 2011年上海市科学技术奖一等奖:阿尔茨海默病及相关认知障碍的发病机制和诊治的基础与临床”(排七,No.20114292-1-R07

(13) 2011年江苏医学科技奖二等奖:精神疾病认知障碍的发病机制与临床研究”(排三,No. 2011A024P5-3

(14) 2011年张香桐神经科学研究生论文奖一等奖”

(15) 2011年南京市科技进步奖三等奖:老年抑郁症认知损害的机制研究”(排三,No. 2011000143

(16) “2011GSK Tomorrow's Star Award”

(17) 2009年度宝钢教育优秀学生特等奖”

(18) 2009年江苏省医学新技术引进奖一等奖:遗忘型轻度认知功能损害诊断的临床应用”(排二)


学术成果

第一作者及通讯作者论文(注:*为通讯作者,以2014IF计算)

(1)Su F, Bai F*, Zhou H, Zhang Z. Microglial toll-like receptors and Alzheimer’s disease. Brain Behav Immun. 2016; 52: 187-198. (IF=5.889)

(2)Su F, Bai F*, Zhang Z. Inflammatory Cytokines and Alzheimer's Disease: A Review from the Perspective of Genetic Polymorphisms. Neurosci Bull. 2016;32(5):469-480.(IF=2.509)

(3)Ye Q, Bai F*, Zhang Z. Shared Genetic Risk Factors for Late-life Depression and Alzheimer’s Disease.J Alzheimers Dis. 2016; 52: 1-15.(IF=4.151)

(4)Ye Q, Su F, Shu H, Gong L, Xie C, Zhang Z, Bai F*. The apolipoprotein E gene affects the three year trajectories of compensatory neural processes in the left lateralized hippocampal network. Brain Imaging Behav. 2016; doi:10.1007/s11682-016-9623-5. (IF=4.598)

(5)Bai F*, Shi Y, Yuan Y, Xie C, Zhang Z*. Immunity factor contributes to altered brain functional networks in individuals at risk for Alzheimer’s disease: Neuroimaging-genetic evidence. Brain Behav Immun.  2016; 56: 84-95. (IF=5.889)

(6)Bai F*, Yuan Y, Shi Y, Zhang Z*. Multiple genetic imaging study of the association between cholesterol metabolism and brain functional alterations in individuals with risk factors for Alzheimer’s disease. Oncotarget. 2016; 7: 15315-15328. (IF=6.359)

(7)Bai F*#, Liao W#, Yue C, Pu M, Shi Y, Yu H, Yuan Y, Geng L, Zhang Z*. Genetics pathway-based imaging approaches in Chinese Han population with Alzheimer's disease risk. Brain Struct Funct. 2016; 221(1): 433-446. (#并列(9Bai F#, Shu N#, Yuan Y, Shi Y, Yu H, Wu D, Wang J, Xia M, He Y*, Zhang Z*. Topologically convergent and divergent structural connectivity patterns between patients with remitted geriatric depression and amnestic mild cognitive impairment. J Neurosci. 2012; 32(12): 4307-4318.(cover paper#并列第一,IF=6.344)

(10)Xie C#, Bai F#, Yu H, Shi Y, Yuan Y, Chen G, Li W, Chen G, Zhang Z*, Li SJ*. Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment. Neuroimage. 2012; 63(1): 320-327. (#并列第一,IF=6.357)

(11)Bai F, Shi Y, Yuan Y, Wang Y, Yue C, Teng Y, Wu D, Zhang Z, Jia J*, Zhang Z*. Altered self-referential network in resting-state amnestic type mild cognitive impairment. Cortex. 2012; 48(5): 604-613. (IF=5.128)

(12)Bai F, Watson DR, Shi Y, Yuan Y, Yu H, Zhang Z*. Mobilization and redistribution of default mode network from resting state to task state in amnestic mild cognitive impairment. Curr Alzheimer Res. 2012; 9(8): 944-952. (IF=3.889)

(13)Bai F, Shi Y, Yuan Y, Yue C, Zhuang L, Xu X, Liu X, Zhang Z*. Association of a GSK-3β polymorphism with brain resting-state function in amnestic-type mild cognitive impairment. J Alzheimers Dis. 2012; 32(2): 387-396. (IF=4.151)

(14)Bai F, Liao W, Watson DR, Shi Y, Yuan Y, Cohen AD, Xie C, Wang Y, Yue C, Teng Y, Wu D, Jia J, Zhang Z*. Mapping the altered patterns of cerebellar resting-state function in longitudinal amnestic mild cognitive impairment patients. J Alzheimers Dis. 2011; 23(1): 87-99. (IF=4.151)

(15)Bai F, Xie C, Watson DR, Shi Y, Yuan Y, Wang Y, Yue C, Teng Y, Wu D, Zhang Z*. Aberrant hippocampal subregion networks associated with the classifications of aMCI subjects: a longitudinal resting-state study. PLoS One. 2011a; 6(12): e29288. (IF=3.234)

(16)Bai F, Watson DR, Shi Y, Wang Y, Yue C, Teng Y, Wu D, Yuan Y, Zhang Z*. Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment. PLoS One. 2011b; 6(9):e24271. (IF=3.234)

(17)Bai F, Liao W, Watson DR, Shi Y, Wang Y, Yue C, Teng Y, Wu D, Yuan Y, Jia J, Zhang Z*. Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients. Behav Brain Res. 2011; 216(2): 666-672. (IF=3.028)

(18)Bai F, Zhang Z*, Watson DR, Yu H, Shi Y, Yuan Y, Zang Y, Zhu C, Qian Y. Abnormal functional connectivity of hippocampus during episodic memory retrieval processing network in amnestic mild cognitive impairment. Biol Psychiatry. 2009; 65(11): 951-958. (cover paper IF=10.255)

(19)Bai F, Watson DR, Yu H, Shi Y, Yuan Y, Zhang Z*. Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment. Brain Res. 2009; 1302: 167-174. (IF=2.843)

(20)Bai F, Zhang Z*, Watson DR, Yu H, Shi Y, Yuan Y, Qian Y, Jia J. Abnormal integrity of association fiber tracts in amnestic mild cognitive impairment. J Neurol Sci. 2009; 278(1-2): 102-106. (IF=2.474)

(21)Bai F, Zhang Z*, Watson DR, Yu H, Shi Y, Zhu W, Wang L, Yuan Y, Qian Y. Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment. Neurosci Lett. 2009a; 450(2): 85-89. (IF=2.03)

(22)Bai F, Zhang Z*, Watson DR, Yu H, Shi Y, Yuan Y. Abnormal white matter independent of hippocampal atrophy in amnestic type mild cognitive impairment. Neurosci Lett. 2009b; 462(2): 147-151. (IF=2.03)

(23)Bai F, Zhang Z*, Yu H, Shi Y, Yuan Y, Zhu W, Zhang X, Qian Y. Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: a combined structural and resting-state functional MRI study. Neurosci Lett. 2008; 438(1): 111-115. (IF=2.03)

(24)Bai F, Watson RD, Zhang Z*. Hippocampal dysfunction in amnestic type mild cognitive impairment-implications for predicting Alzheimer’s risk. Future neurology. 2009; 4: 649-662.

合作作者论文:

(25)Wang Z, Yuan Y, Bai F, You J, Zhang Z*. Altered topological patterns of brain networks in remitted late-onset depression: a resting-state fMRI study. J Clin Psychiatry. 2016; 77(1): 123-130. (IF=5.498)

(26)Gong L, Yin Y, He C, Ye Q, BaiF, Yuan Y, Zhang H, Lv L, Zhang H, Xie C, Zhang Z. Disrupted rewardcircuits is associated with cognitive deficits and depression severity in majordepressive disorder. J Psychiatr Res. 2016; 84: 9-17.(IF=3.957)

(27)Gong WG, Wang YJ, Zhou H,Li XL, Bai F, Ren QG, Zhang ZJ.Citalopram Ameliorates Synaptic Plasticity Deficits in DifferentCognition-Associated Brain Regions Induced by Social Isolation in Middle-AgedRats. Mol Neurobiol. 2016 Feb 22. [Epub ahead of print].(IF=5.137)

(28)Tang X, Wu D, Gu LH, NieBB, Qi XY, Wang YJ, Wu FF, Li XL, Bai F,Chen XC, Xu L, Ren QG, Zhang ZJ. Spatial learning and memory impairments areassociated with increased neuronal activity in 5XFAD mouse as measured bymanganese-enhanced magnetic resonance imaging. Oncotarget. 2016 Aug 17. [Epubahead of print] (IF=6.359)

(29)Sun J, Zhou H, Bai F, Ren Q, Zhang Z. Myelin injuryinduces axonal transport impairment but not AD-like pathology in thehippocampus of cuprizone-fed mice. Oncotarget. 2016;7(21):30003-30017. (IF=6.359)

(30)Wang YJ, Ren QG, Gong WG,Wu D, Tang X, Li XL, Wu FF, Bai F,Xu L, Zhang ZJ. Escitalopram attenuates β-amyloid-induced tauhyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway.Oncotarget. 2016; 7(12): 13328-13339. (IF=6.359)

(31)Xie C, Bai F, Yuan B, Yu H, Shi Y, Yuan Y, Wu D, Zhang Z, Zhang Z*. Joint effects of gray matter atrophy and altered functional connectivity on cognitive deficits in amnestic mild cognitive impairment patients. Psychol Med. 2015; 45(9): 1799-1810. (IF=5.938)

(32)Wang Z, Yuan Y, Bai F, Shu H, You J, Li L, Zhang Z*. Altered functional connectivity networks of hippocampal subregions in remitted late-onset depression: a longitudinal resting-state study. Neurosci Bull. 2015; 31(1): 13-21. (IF=2.509)

(33)Yue C, Wu D, Bai F, Shi Y, Yu H, Xie C, Zhang Z*. State-based functional connectivity changes associate with cognitive decline in amnestic mild cognitive impairment subjects. Behav Brain Res. 2015; 288: 94-102. (IF=3.028)

(34)Huang J, Bai F, Yang X, Chen C, Bao X, Zhang Y*. Identifying brain functional alterations in postmenopausal women with cognitive impairment. Maturitas. 2015; 81(3): 371-376. (IF=2.942)

(35)Shu H, Yuan Y, Xie C, Bai F, You J, Li L, Li S, Zhang Z*. Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E ε4 allele in nondemented elderly: a preliminary study. J Affect Disord. 2014; 164: 5-13. (IF=3.383)

(36)Liu X, Bai F, Yue C, Shi Y, Yu H, Luo B, Zhang Z*. The association between TOMM40 gene polymorphism and spontaneous brain activity in amnestic mild cognitive impairment. J Neurol. 2014; 261(8): 1499-1507. (IF=3.377)

(37)Jiang W, Yuan YG, Zhou H, Bai F, You J, Zhang Z*. Abnormally altered patterns of whole brain functional connectivity network of posterior cingulate cortex in remitted geriatric depression: a longitudinal study. CNS Neurosci Ther. 2014; 20(8): 772-777. (IF=3.931)

(38)Yue Y, Yuan Y*, Hou Z, Jiang W, Bai F, Zhang Z. Abnormal functional connectivity of amygdala in late-onset depression was associated with cognitive deficits. PLoS One. 2013; 8(9): e75058. (IF=3.234)

(39)Xia W, Wang S*, Sun Z, Bai F, Zhou Y, Yang Y, Wang P, Huang Y, Yuan Y. Altered baseline brain activity in type 2 diabetes: a resting-state fMRI study. Psychoneuroendocrinology. 2013; 38(11): 2493-2501. (IF=4.944)

(40)Mou X, Bai F, Xie C, Shi J, Yao Z, Hao G, Chen N, Zhang Z*. Voice recognition and altered connectivity in schizophrenic patients with auditory hallucinations. Prog Neuropsychopharmacol Biol Psychiatry. 2013; 44: 265-270. (IF=3.689)

(41)Wu D, Yuan Y, Bai F, You J, Li L, Zhang Z*. Abnormal functional connectivity of the default mode network in remitted late-onset depression. J Affect Disord. 2013; 147(1-3): 277-287. (IF=3.383)

(42)Zhuang L, Liu X, Xu X, Yue C, Shu H, Bai F, Yu H, Shi Y, Zhang Z*. Association of the interleukin 1 beta gene and brain spontaneous activity in amnestic mild cognitive impairment. J Neuroinflammation. 2012; 9: 263. (IF=5.408)

(43)Zhang Z, Deng L, Yu H, Shi Y, Bai F, Xie C, Yuan Y, Jia J, Zhang Z*. Association of angiotensin-converting enzyme functional gene I/D polymorphism with amnestic mild cognitive impairment. Neurosci Lett. 2012; 514(1): 131-135. (IF=2.03)

(44)Wang Z, Yuan Y, Bai F, You J, Li L, Zhang Z*. Abnormal default-mode network in angiotensin converting enzyme D allele carriers with remitted geriatric depression. Behav Brain Res. 2012; 230(2): 325-332. (IF=3.028)

(45)Watson DR*, Anderson JM, Bai F, Barrett SL, McGinnity TM, Mulholland CC, Rushe TM, Cooper SJ. A voxel based morphometry study investigating brain structural changes in first episode psychosis. Behav Brain Res. 2012; 227(1): 91-99. (IF=3.028)

(46)Watson DR*, Bai F, Barrett SL, Turkington A, Rushe TM, Mulholland CC, Cooper SJ. Structural changes in the hippocampus and amygdala at first episode of psychosis. Brain Imaging Behav. 2012; 6(1): 49-60. (IF=4.598)

(47)Hou Z, Yuan Y*, Zhang Z, Bai F, Hou G, You J. Longitudinal changes in hippocampal volumes and cognition in remitted geriatric depressive disorder. Behav Brain Res. 2012; 227(1): 30-35. (IF=3.028)

(48)Hoy K, Barrett S, Shannon C*, Campbell C, Watson D, Rushe T, Shevlin M, Bai F, Cooper S, Mulholland C. Childhood trauma and hippocampal and amygdalar volumes in first-episode psychosis. Schizophr Bull. 2012; 38(6): 1162-1169. (IF=8.45)

(49)Zhang Z, Deng L, Bai F, Shi Y, Yu H, Yuan Y, Jiang T, Jia J, Zhang Z*. ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment. Behav Brain Res. 2011; 218(1): 114-120. (IF=3.028)

(50)Hou Z, Yuan Y*, Zhang Z, Hou G, You J, Bai F. The D-allele of ACE insertion/deletion polymorphism is associated with regional white matter volume changes and cognitive impairment in remitted geriatric depression. Neurosci Lett. 2010; 479(3): 262-266. (IF=2.03)

(51)Yuan Y, Hou Z, Zhang Z*, Bai F, Yu H, You J, Shi Y, Liu W, Jiang T. Abnormal integrity of long association fiber tracts is associated with cognitive deficits in patients with remitted geriatric depression: a cross-sectional, case-control study. J Clin Psychiatry. 2010; 71(10): 1386-1390. (IF=5.498)

(52)Zhou H, Lu W, Shi Y, Bai F, Chang J, Yuan Y, Teng G*, Zhang Z. Impairments in cognition and resting-state connectivity of the hippocampus in elderly subjects with type 2 diabetes. Neurosci Lett. 2010; 473(1): 5-10. (IF=2.03)

(53)Zhang Z, Deng L, Bai F, Shi Y, Yu H, Yuan Y, Wang K, Jiang T, Jia J, Zhang Z*. Alteration of resting brain function by genetic variation in angiotensin converting enzyme in amnestic-type mild cognitive impairment of Chinese Han. Behav Brain Res. 2010; 208(2): 619-625. (IF=3.028)

(54)Shi Y, Zhou H, Zhang Z*, Yu H, Bai F, Yuan Y, Deng L, Jia J. Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese. Int Psychogeriatr. 2009; 21(6): 1072-1080. (IF=1.934)

(55)Yuan Y, Zhang Z*, Bai F, You J, Yu H, Shi Y, Liu W. Genetic variation in apolipoprotein E alters regional gray matter volumes in remitted late-onset depression. J Affect Disord. 2010; 121(3): 273-277. (IF=3.383)

(56Yuan Y, Zhang Z*, Bai F, Yu H, You J, Shi Y, Qian Y, Liu W, Jiang T. Larger regional white matter volume is associated with executive function deficit in remitted geriatric depression: an optimized voxel-based morphometry study. J Affect Disord. 2009; 115(1-2): 225-229. (IF=3.383)

(57)Yuan Y, Zhu W, Zhang Z*, Bai F, Yu H, Shi Y, Qian Y, Liu W, Jiang T, You J, Liu Z. Regional gray matter changes are associated with cognitive deficits in remitted geriatric depression: an optimized voxel-based morphometry study. Biol Psychiatry. 2008; 64(6): 541-544. (IF=10.255)

(58)Yu H, Zhang Z*, Shi Y, Bai F, Xie C, Qian Y, Yuan Y, Deng L. Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. J Clin Psychiatry. 2008; 69(7): 1104-1111. (IF=5.498)

(59)Yuan Y, Zhang Z*, Bai F, Yu H, Shi Y, Qian Y, Liu W, You J, Zhang X, Liu Z. Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study. J Affect Disord. 2008; 111(2-3): 145-152. (IF=3.383)

(60)Yuan Y, Zhang Z*, Bai F, Yu H, Shi Y, Qian Y, Zang Y, Zhu C, Liu W, You J. White matter integrity of the whole brain is disrupted in first-episode remitted geriatric depression. Neuroreport. 2007; 18(17): 1845-1849. (IF=1.52)